Laryngoscope:早期年龄相关听力损失与脑β-淀粉样蛋白相关性分析

2020-07-26 AlexYang MedSci原创

最近,有研究人员分析了早期年龄相关听力损失与脑β-淀粉样蛋白的相关性,脑β-淀粉样蛋白为阿兹海默症(AD)的一个病理特征。

最近,有研究人员分析了早期年龄相关听力损失与脑β-淀粉样蛋白的相关性,脑β-淀粉样蛋白为阿兹海默症(AD)的一个病理特征。

研究是一个前瞻性群体研究的代表性分析。研究包括了98名参与者。主要结果为正电子发射断层扫描(PET)全脑脑β-淀粉样蛋白标准化摄取值比(SUVR)。研究发现,参与者的平均年龄(标准差)为64.6±3.5岁。在多变量回归中,调整了人口统计、教育、血管疾病和助听器的使用后,纯音均值每增加10dB,全脑β-淀粉样蛋白SUVR就会0.029(95%CI:0.003-0.056)(P=0.030)。相似的,单词识别评分每增加10%,全脑β-淀粉样蛋白SUVR就会增加0.061(95%CI: 0.009-0.112)。

最后,研究人员指出,更差的听力与更高的β-淀粉样蛋白负担相关。

原始出处:

Justin S Golub , Rahul K Sharma , Brady Q Rippon et al. The Association Between Early Age-Related Hearing Loss and Brain β-Amyloid. Laryngoscope. 09 July 2020

 

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    2020-10-12 feather89
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    2020-07-28 ysjykql
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