BMJ:幼儿期接受暴露于水痘后对成人期带状疱疹发病率的影响

2020-03-08 MedSci原创 MedSci原创

婴幼儿时期暴露于水痘危险中对其成人后带状疱疹的发病率究竟是怎样的呢?

背景及目的:

本项研究旨在评估接触水痘患儿对成人带状疱疹相对发生率的保护作用的幅度和持续时间。

方法:

研究人员收集了在1997年至2018年之间诊断为带状疱疹的9604名成人(≥18岁),在观察期内与一个被确诊为水痘的孩子(<18岁)一起生活。主要结局指标家庭中接触水痘患儿后20年带状疱疹的相对发生率与基线时间相比。

结果:

9604名带状疱疹的成人中有6584名(68.6%)是女性。水痘患儿接触的中位年龄为38.3岁(四分位间距为32.3-48.8岁),中位观察期为14.7(11.1-17.7)岁。在基线期有4116个成年人发生带状疱疹,在暴露前60天有433个成年人,在危险期有5055个成年人。在对年龄,日历时间和季节进行调整之后,有力的证据表明,家庭接触水痘儿童后的两年中,成年人患带状疱疹的可能性降低了33%(发生率0.67,95%置信区间0.62至0.73)。与基准时间相比。在暴露后的10-20年中,与基线时间相比,成年人患带状疱疹的可能性降低了27%(0.73,0.62至0.87)。

结论:

家庭接触水痘后,带状疱疹的相对发病率较低,具有适度但持久的保护作用。

原始出处:

Harriet Forbes. Et al. Risk of herpes zoster after exposure to varicella to explore the exogenous boosting hypothesis: self controlled case series study using UK electronic healthcare data. BMJ.2020. 

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    2021-01-18 12433b5em73暂无昵称

    类似疫苗的作用……

    0

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    2020-11-17 gaoxiaoe
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