JAHA:血压、血糖、胆固醇或体重的变异性对急诊住院和30天死亡率的影响

2020-11-07 MedSci原创 MedSci原创

代谢参数的高变异性与急诊住院和短期死亡的风险增加有关。

血压、血糖、胆固醇或体重的变异性与多种健康结局相关。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在假设代谢参数的高变异性与急诊住院和死亡风险增加有关。

研究人员使用韩国国家健康保险系统的全国代表性数据库,对2005年至2010年接受了3次及以上健康检查的8049228个人进行了随访,并随访至2016年。研究人员使用独立于平均值的变异性(VIM)来测量空腹血糖、总胆固醇浓度、收缩压和体重的变异性。高变异性被定义为变异性最高四分位数。根据高变异性参数的数量对受试者进行分类。研究的终点是急诊住院和30天死亡率。

受试者中位随访时间为5.6±1.2年,共发生733387例急诊住院治疗(9.1%)。对于每个代谢参数,较高的VIM四分位数组比最低的四分位数组观察到的急诊住院风险逐渐增加。调整可能的混杂因素后,与所有四个参数均具有较低变异性的组相比,所有四个参数均具有较高变异性的组的急诊住院风险显著升高(风险比[HR]为1.58;95%CI为1.54–1.61)和30天死亡率(HR为2.44;95%CI为1.62-3.69)。

由此可见,代谢参数的高变异性与急诊住院和短期死亡的风险增加有关。

原始出处:

Seung‐Hwan Lee.et al.Effect of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Weight on Emergency Hospitalization and 30‐Day Mortality in the General Population.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.016836

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    2021-07-12 smlt2008
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    2020-11-09 zhaohui6731
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