Sci Rep:埃及血吸虫特异性microRNA作为血吸虫性膀胱癌预测和预后工具的作用

2020-11-16 AlexYang MedSci原创

泌尿系膀胱癌是埃及常见的恶性肿瘤,因此需要可靠的方法进行筛查和早期检测。

泌尿系膀胱癌是埃及常见的恶性肿瘤,因此需要可靠的方法进行筛查和早期检测。

最近,有研究人员分析了50名膀胱癌患者和50名良性血吸虫性膀胱炎患者尿液样本中一种血吸虫特异性microRNA "Sha-miR-71a "和丝裂原相关蛋白激酶-3(MAPK-3)的基因表达情况,同时对50名对照组进行了检测。研究发现,间接血凝试验(IHA)诊断70%的已研究癌症病例为血吸虫性相关膀胱癌(BBC),而组织病理学检查仅检测到18%。尿液中Sha-miR-71a & MAPK-3在BBC中与非血吸虫性膀胱癌(NBBC)病例相比表达增强(P=0.001)。与急性感染的患者相比,慢性血吸虫性膀胱炎患者的基因表达显著增加(p=0.001)。接受者操作特征(ROC)曲线分析表明,Sha-miR-71a和MAPK-3在BBC的诊断中表现出良好的敏感性和特异性。另外,它们对于恶性肿瘤等级也具有预后性,且两种生物标志物均呈正相关。

不同小组中sha-miR-71a & MAPK3基因表达水平比较

最后,研究人员指出,IHA是诊断血吸虫性相关膀胱癌的可靠检测方法,Sha-miR-71a和MAPK-3为诊断BBC提供了无创的特异性生物标志物,并在检测血吸虫性患者患癌风险方面具有潜在作用。

原始出处:

Dalia A. Gaber, Rita M. Wassef, Wael M. El-Ayat et al. Role of a schistosoma haematobium specific microRNA as a predictive and prognostic tool for bilharzial bladder cancer in Egypt. Sci Rep. Nov 2020

 

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    2021-03-03 xjy02
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    2020-11-18 ylz8404
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    2020-11-18 zhouqu_8
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    2020-11-16 留走人康

    膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效

    0

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