JCEM:辅酶Q10和/或维生素E对多囊卵巢综合征患者激素和代谢的影响

2018-09-10 xing.T MedSci原创

总之,PCOS女性联合或不联合维生素E补充CoQ10对血清FBS和胰岛素水平以及HOMA-IR和总睾酮水平具有有益的作用。然而,只有联合补充能够影响SHBG的浓度。

多囊卵巢综合征(PCOS)是育龄妇女最常见的内分泌疾病。没有研究评估辅酶Q10和/或维生素E对PCOS患者的激素和代谢作用。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估辅酶Q10和/或维生素E对PCOS女性葡萄糖稳态参数和生殖激素的影响。

该研究为在86例PCOS患者中进行的随机双盲安慰剂对照临床试验,受试者接受辅酶Q10(辅酶Q10)或维生素E或其组合治疗8周。该研究的主要观察指标为葡萄糖稳态参数和性激素浓度。

研究人员观察到在调整潜在的混杂因素后,与安慰剂相比,单独补充CoQ10或与维生素E联合补充对空腹血糖(FBS)有显著影响,而维生素E对FBS的影响无统计学意义。在CoQ10和联合组中可观察到稳态模型评估的胰岛素抵抗(HOMA-IR)显著降低。与安慰剂组相比,辅酶Q10、维生素E和联合补充剂可降低血清总睾酮水平(P<0.001)。与其他组相比,辅酶Q10与维生素E联合补充可导致性激素结合球蛋白(SHBG)显著改善(P=0.008)。线性回归分析的结果显示FBS、胰岛素和HOMA-IR的改变是FAI变化的预测因子(P<0.05)。

总之,PCOS女性联合或不联合维生素E补充CoQ10对血清FBS和胰岛素水平以及HOMA-IR和总睾酮水平具有有益的作用。然而,只有联合补充能够影响SHBG的浓度。

原始出处:

Azimeh Izadi,et al.Hormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients with Polycystic Ovary Syndrome.J Clin Endocrinol Metab. 2018.https://doi.org/10.1210/jc.2018-01221

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    2023-02-06 好奇心饱饱 来自广东省

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    2019-02-05 achengzhao
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  4. [GetPortalCommentsPageByObjectIdResponse(id=2113208, encodeId=cc1e211320852, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3078416159, createdName=好奇心饱饱, createdTime=Mon Feb 06 08:26:20 CST 2023, time=2023-02-06, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=2063206, encodeId=7e2c20632066b, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Feb 05 12:48:00 CST 2019, time=2019-02-05, status=1, ipAttribution=), 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createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Sep 30 01:48:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353867, encodeId=dfb735386ebe, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Nov 28 12:19:45 CST 2018, time=2018-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1716494, encodeId=dcbd1e1649432, content=<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104f32235338, createdName=drwjr, createdTime=Tue May 28 11:48:00 CST 2019, time=2019-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349767, encodeId=27f7349e6741, content=剂量是多少呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erFE1IgJcfnOGsibGrna95eBt7ELNXK85krdEJ0RAYjiaU11PyPj40c1BsktlfCfLH0n9jm99iahR06w/132, createdBy=05422454711, createdName=慧子, createdTime=Thu Oct 18 23:38:45 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345092, encodeId=734234509279, content=PCOS又有了新进展~研究不断更新,更多女性将受到更好的呵护,谢谢分享~, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/E18UCgMWjKMX78AZh8tibHWJwic0RdRd5qEDVIqYaP8mRTGNQzLXl1rRY7DrPbEN6rqUQT3erianoQ8GTNy80HibYg/132, createdBy=d56d2394168, createdName=唐七七七, createdTime=Sat Sep 15 10:57:43 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419842, encodeId=d0211419842bb, content=<a href='/topic/show?id=60f8e908078' target=_blank style='color:#2F92EE;'>#维生素E#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79080, encryptionId=60f8e908078, topicName=维生素E)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fe53536268, createdName=marongnuan, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431321, encodeId=fff51431321ec, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-09-30 smallant2015
  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/E18UCgMWjKMX78AZh8tibHWJwic0RdRd5qEDVIqYaP8mRTGNQzLXl1rRY7DrPbEN6rqUQT3erianoQ8GTNy80HibYg/132, createdBy=d56d2394168, createdName=唐七七七, createdTime=Sat Sep 15 10:57:43 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419842, encodeId=d0211419842bb, content=<a href='/topic/show?id=60f8e908078' target=_blank style='color:#2F92EE;'>#维生素E#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79080, encryptionId=60f8e908078, topicName=维生素E)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fe53536268, createdName=marongnuan, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431321, encodeId=fff51431321ec, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-11-28 kafei

    了解一下谢谢

    0

  6. 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topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104f32235338, createdName=drwjr, createdTime=Tue May 28 11:48:00 CST 2019, time=2019-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349767, encodeId=27f7349e6741, content=剂量是多少呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erFE1IgJcfnOGsibGrna95eBt7ELNXK85krdEJ0RAYjiaU11PyPj40c1BsktlfCfLH0n9jm99iahR06w/132, createdBy=05422454711, createdName=慧子, createdTime=Thu Oct 18 23:38:45 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345092, encodeId=734234509279, content=PCOS又有了新进展~研究不断更新,更多女性将受到更好的呵护,谢谢分享~, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/E18UCgMWjKMX78AZh8tibHWJwic0RdRd5qEDVIqYaP8mRTGNQzLXl1rRY7DrPbEN6rqUQT3erianoQ8GTNy80HibYg/132, createdBy=d56d2394168, createdName=唐七七七, createdTime=Sat Sep 15 10:57:43 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419842, encodeId=d0211419842bb, content=<a href='/topic/show?id=60f8e908078' target=_blank style='color:#2F92EE;'>#维生素E#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79080, encryptionId=60f8e908078, topicName=维生素E)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fe53536268, createdName=marongnuan, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431321, encodeId=fff51431321ec, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2019-05-28 drwjr
  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/E18UCgMWjKMX78AZh8tibHWJwic0RdRd5qEDVIqYaP8mRTGNQzLXl1rRY7DrPbEN6rqUQT3erianoQ8GTNy80HibYg/132, createdBy=d56d2394168, createdName=唐七七七, createdTime=Sat Sep 15 10:57:43 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419842, encodeId=d0211419842bb, content=<a href='/topic/show?id=60f8e908078' target=_blank style='color:#2F92EE;'>#维生素E#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79080, encryptionId=60f8e908078, topicName=维生素E)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fe53536268, createdName=marongnuan, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431321, encodeId=fff51431321ec, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-10-18 慧子

    剂量是多少呢

    0

  8. 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encodeId=fff51431321ec, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 12 07:48:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-09-15 唐七七七

    PCOS又有了新进展~研究不断更新,更多女性将受到更好的呵护,谢谢分享~

    0

  9. 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  10. 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