Hum Reprod Update:李艳萍教授团队综述脂质代谢与生育关系

2022-06-12 MedSci原创 MedSci原创

近日,中南大学湘雅医院生殖医学中心、湖南省女性生殖健康临床研究中心李艳萍教授团队和中南大学湘雅二医院代谢综合征研究中心刘峰教授在国际妇产科和生殖生物学顶尖期刊《Human Reproduction U

近日,中南大学湘雅医院生殖医学中心、湖南省女性生殖健康临床研究中心李艳萍教授团队和中南大学湘雅二医院代谢综合征研究中心刘峰教授在国际妇产科和生殖生物学顶尖期刊《Human Reproduction Update》(影响因子:15.610;Q1)上发表题为“Lipid metabolism and endometrial receptivity”的综述性论文。李艳萍教授和刘峰教授为论文共同通讯作者,中南大学湘雅医院生殖医学中心博士研究生杨天丽为第一作者、副研究员赵静为第二作者。中南大学湘雅医院为第一和通讯单位。

图片随着现代化社会转型和当代人群生活水平的不断提高,肥胖已成为全球共同关注的卫生健康议题之一。已有大量研究表明,肥胖对人类生殖健康有长远的影响。肥胖,其本质是脂代谢紊乱引起的脂肪积聚过多。

本文由临床现象切入,综述了肥胖、血脂异常、PCOS对ART妊娠结局,尤其是子宫内膜容受性的影响;再从几个主要脂质脂肪酸、磷脂、胆固醇入手,深入探讨各脂质参与胚胎着床的可能机制;最后引入近年来转录组学及脂质组学相关研究进展,为未来寻找无创生物标志物提供理论基础。

图片

李艳萍教授课题组长年致力于反复种植失败、胚胎种植机制、子宫内膜容受性的研究工作,首创基于RNA-Seq技术,利用转录组生物标记物和人工智能方法进行子宫内膜容受性检测的工具——ERT。2021年在全球首次综合运用胚胎植入前遗传学检测(PGT)和ERT两种精准组学技术成功阻断多发性内分泌腺瘤I型致女性不孕症患者的致病基因并帮助她获得健康子代。

原始出处:

Yang T, Zhao J, Liu F, Li Y.Lipid metabolism and endometrial receptivity.Hum Reprod Update (IF: 15.61; Q1). 2022 May 27:dmac026. doi: 10.1093/humupd/dmac026.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1796641, encodeId=f5481e96641ac, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Thu Jan 26 22:44:47 CST 2023, time=2023-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353410, encodeId=ee9613534103a, content=<a href='/topic/show?id=c4d484423fa' target=_blank style='color:#2F92EE;'>#脂质代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84423, encryptionId=c4d484423fa, topicName=脂质代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Jun 15 01:44:47 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602433, encodeId=960c160243355, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Wed Jun 15 01:44:47 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1226269, encodeId=4a211226269b1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7fe25504874, createdName=ms4000000847044769, createdTime=Mon Jun 13 22:22:19 CST 2022, time=2022-06-13, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1796641, encodeId=f5481e96641ac, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Thu Jan 26 22:44:47 CST 2023, time=2023-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353410, encodeId=ee9613534103a, content=<a href='/topic/show?id=c4d484423fa' target=_blank style='color:#2F92EE;'>#脂质代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84423, encryptionId=c4d484423fa, topicName=脂质代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Jun 15 01:44:47 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602433, encodeId=960c160243355, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Wed Jun 15 01:44:47 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1226269, encodeId=4a211226269b1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7fe25504874, createdName=ms4000000847044769, createdTime=Mon Jun 13 22:22:19 CST 2022, time=2022-06-13, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1796641, encodeId=f5481e96641ac, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Thu Jan 26 22:44:47 CST 2023, time=2023-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353410, encodeId=ee9613534103a, content=<a href='/topic/show?id=c4d484423fa' target=_blank style='color:#2F92EE;'>#脂质代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84423, encryptionId=c4d484423fa, topicName=脂质代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Jun 15 01:44:47 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602433, encodeId=960c160243355, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Wed Jun 15 01:44:47 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1226269, encodeId=4a211226269b1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7fe25504874, createdName=ms4000000847044769, createdTime=Mon Jun 13 22:22:19 CST 2022, time=2022-06-13, status=1, ipAttribution=)]
    2022-06-15 sunylz
  4. [GetPortalCommentsPageByObjectIdResponse(id=1796641, encodeId=f5481e96641ac, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Thu Jan 26 22:44:47 CST 2023, time=2023-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353410, encodeId=ee9613534103a, content=<a href='/topic/show?id=c4d484423fa' target=_blank style='color:#2F92EE;'>#脂质代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84423, encryptionId=c4d484423fa, topicName=脂质代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Jun 15 01:44:47 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602433, encodeId=960c160243355, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Wed Jun 15 01:44:47 CST 2022, time=2022-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1226269, encodeId=4a211226269b1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7fe25504874, createdName=ms4000000847044769, createdTime=Mon Jun 13 22:22:19 CST 2022, time=2022-06-13, status=1, ipAttribution=)]
    2022-06-13 ms4000000847044769

    学习了

    0

相关资讯

致女性不孕风险翻倍,罪魁祸首竟或是......打鼾?

PLOS ONE:阻塞性睡眠呼吸暂停增加女性不孕风险:一项14年全省人口为基础的研究

生育不易且伴随高患癌风险,这群男性真的“难”

生殖系统的病变常常是男性罹患其他疾病的先兆,研究表明患有不育症的男性,其罹患各种癌症的风险都会增加。

2045年男性将“绝精”?内裤材质是否影响精子质量?广东省精子库专家一一解释

研究显示,20世纪70年代男性平均每毫升精液有9900万个精子, 2011年精子数量降至4700万个,即40年间降幅达53%。

三孩生育政策来了,你还躺平吗?

5月31日,中共中央政治局5月31日召开会议,听取“十四五”时期积极应对人口老龄化重大政策举措汇报,审议《关于优化生育政策促进人口长期均衡发展的决定》。

女性有望掌握生育权!Nature重磅:近乎完美的人类囊胚模型诞生

生育自古以来都是人类最重要的生命过程之一,然而即使到了医学水平较为发达的现代社会,人类,尤其是女性,依旧很难掌控自己生育能力。