Heart:相距30岁的两个男性队列心衰发生率和危险因素比较

2020-03-01 xing.T MedSci原创

由此可见,1943年出生的男子在50岁以后患HF的风险是30年前出生男性的一半。AF、肥胖症、缺血性心脏病、糖尿病和高血压仍然是HF的重要危险因素。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,这研究旨在比较年龄相距30岁的两个中年男性队列心力衰竭(HF)的发生率和预测因素。

研究人员对两个分别出生于1913年(n=855)和1943年(n=797)的男性人群在其50岁时进行了评估,并随访了21年(1963–1994和1993–2014)。研究人员使用Cox回归分析评估了不同因素对HF发生风险的影响。

随访期间,有80名(9.4%)1913年出生的男性和42名(5.3%)1943年出生的男性出现了HF。比较两个队列(出生于1943年与1913年)的校正后HR为0.46(95%CI为0.28至0.74,p=0.002)。在这两个队列中,较大体重指数、较高的舒张压、高血压治疗、房颤(AF)发作、缺血性心脏病和糖尿病均与HF风险较高相关。仅在1913年出生的男性中,较高的心率与增加的HF风险相关,而在1943年出生的男性中,较高的收缩压(SBP)、吸烟、较高的血糖、较高的胆固醇和缺乏体育锻炼与较高的HF风险相关。与1913年出生的男性相比,1943年出生的男性AF导致HF的风险较高,而SBP和缺乏体育锻炼所致的HF风险较低。

由此可见,1943年出生的男子在50岁以后患HF的风险是30年前出生男性的一半。AF、肥胖症、缺血性心脏病、糖尿病高血压仍然是HF的重要危险因素。

原始出处:

Constantinos Ergatoudes.et al.Comparison of incidence rates and risk factors of heart failure between two male cohorts born 30 years apart.heart.2020.http://dx.doi.org/10.1136/heartjnl-2019-316059

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    2020-03-03 zhaojie88
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    2020-03-03 slcumt