Hypertension:HIV感染者累积病毒载量与高血压、糖尿病发生率的关系

2022-08-28 MedSci原创 MedSci原创

累积病毒载量可能与PWH发生高血压有关。PWH的HIV控制与心血管疾病危险因素的关系可能因卫生保健系统不同而有所差异。

HIV会引起代谢紊乱,从而导致心血管疾病,但目前尚不清楚HIV是否会增加糖尿病高血压的风险。细化不同治疗背景中艾滋病毒特异性因素与心血管疾病风险因素之间的纵向关系,可能有助于为艾滋病毒感染者提供预防心血管疾病的诊疗信息。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员通过分析了2004年至2019年期间芝加哥2个不同卫生系统(西北医药和霍华德布朗卫生保健)中的PWH电子记录,研究人员验证了长期较高的累积病毒载量(病毒血症-拷贝-年)与较高的糖尿病和高血压风险之间存在相关的假设。研究人员使用关节纵向生存模型来评估多变量调整的相关性。每个站点也进行了亚组分析。

研究人员观察到7628例无基线糖尿病的PWH中有230例(3.0%)发生糖尿病,7450例基线无高血压的PWH中有496例(6.7%)发生高血压。合并分析显示病毒血症-拷贝-年与高血压发病有直接关系(风险比为1.20[95%CI为1.14-1.26]),但与糖尿病无直接关系(风险比为1.03[95%CI为0.96-1.10])。

然而,存在站点特异性差异,仅西北地区的分析显示病毒血症-拷贝-年与高血压显著相关(风险比为1.29[95%CI为1.08-1.32])。此外,较高的社会剥夺指数(两个站点)和精神健康障碍诊断(仅霍华德布朗健康)与较高的糖尿病和高血压风险相关。

由此可见,累积病毒载量可能与PWH发生高血压有关。PWH的HIV控制与心血管疾病危险因素的关系可能因卫生保健系统不同而有所差异。

原始出处:

Adovich S. Rivera.et al.Association of Cumulative Viral Load With the Incidence of Hypertension and Diabetes in People With HIV.Hypertension.2022.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19302

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    2022-08-28 ms6000000960504356

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