Neurology: 顾东风院士联合阜外医院发现:多基因风险评分可反映脑中风预后

2021-06-17 Freeman MedSci原创

顾东风院士联合阜外医院发现:多基因风险评分可预测脑中风预后

由于中风导致的死亡正在扩大对全球健康的威胁。在中国,中风是死亡的主要原因,在2017年占207万死亡人数。因此,早期识别高危人群,倡导健康的生活方式或药物干预,对于中国和全世界的中风初级预防至关重要。

卒中是一种由遗传和环境因素引起的复杂疾病。全基因组关联研究(GWAS)已经发现了42个与脑卒中相关的基因位点,以及数百个与脑卒中相关性状相关的基因位点,包括血压(BP)、2型糖尿病(T2D)、血脂、体重指数(BMI)和心房颤动(AF)。这些遗传变异的识别提供了一个机会,以评估遗传风险是否可以导致未来风险预测和分层的有意义的改善。

最近,针对中风的多基因风险评分(PRS)已经被开发出来,并在欧洲后裔人群中进行了临床效用评估。然而,它们对中国人群的适用性是值得怀疑的。 卒中的流行病学特征在不同国家有很大差异,中国的卒中发病率和出血性卒中的比例远远高于西方人群。不同人群的临床危险因素和遗传背景的明显差异也可能影响卒中风险的变化。因此,生成中国人群中风的PRS是非常重要的。

藉此,阜外医院的Xiangfeng Lu通过对东亚血统的大规模GWAS汇总统计,构建了中风的综合PRS(metaPRS),然后在大型前瞻性人群队列中验证了其在中风风险分层和初级预防中的效用。

他们通过荟萃分析方法和大规模GWAS,对东亚人中风和中风相关性状的分析,在2,872名中风患者和2,494名对照组的训练集中纳入了534个遗传变异,生成了一个联合PRS(metaPRS)。然后,在包括41,006人的大型中国人群前瞻性队列中使用Cox回归模型验证了其与发生中风的关系。

结果表明,在共367,750人年中(平均随访9.0年),1,227名参与者在80岁之前发生了中风。与低多基因风险的个体相比,高多基因风险的个体发生中风的风险高出约2倍(HR:1.99,95%CI:1.66-2.38),中风的终身风险分别为25.2%(95%CI:22.5%-27.7%)和13.6%(95%CI:11.6%-15.5%)。

同时具有高多基因风险和家族史的个体显示终生风险高达41.1%(95%CI:31.4%-49.5%)。

此外,与低多基因风险的个体相比,高多基因风险的个体在坚持理想的空腹血糖和总胆固醇的绝对风险降低方面获得了更大的好处。保持良好的血管健康(CVH)状况可以大大减轻高多基因风险赋予的风险增加,达到低多基因风险的水平(从34.6%到13.2%)。

这个研究的重要意义在于,发现了的metaPRS在卒中风险分层和识别可能从保持理想的CVH中获益更多的个体方面有很大的潜力。


原文出处:
Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population
Xiangfeng Lu, Xiaoge Niu, Chong Shen, et al., Dongfeng Gu
Neurology May 2021, 10.1212/WNL.0000000000012263; DOI: 10.1212/WNL.0000000000012263

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[GetPortalCommentsPageByObjectIdResponse(id=2001360, encodeId=5215200136095, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed May 11 08:00:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632086, encodeId=52b8163208685, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Jun 17 09:00:29 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2001360, encodeId=5215200136095, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed May 11 08:00:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632086, encodeId=52b8163208685, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encryptionId=fc4e9e348b6, topicName=阜外医)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Jul 16 08:00:29 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949773, encodeId=878a1949e7310, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Mon Sep 13 00:00:29 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754462, encodeId=977f1e5446253, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Mon Apr 11 14:00:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819939, encodeId=28b01819939c0, content=<a href='/topic/show?id=644a100144e7' target=_blank style='color:#2F92EE;'>#顾东风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100144, encryptionId=644a100144e7, topicName=顾东风)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b96f328, createdName=wwzzly, createdTime=Wed Dec 01 11:00:29 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293771, encodeId=ed7d1293e71a3, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jun 18 21:00:29 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974308, encodeId=56cd9e430875, content=收获满满, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b95527277, createdName=ms7000001261292141, createdTime=Thu Jun 17 09:51:08 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046073, encodeId=299910460e3f3, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Jun 17 09:00:29 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2001360, encodeId=5215200136095, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed May 11 08:00:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632086, encodeId=52b8163208685, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Mon Apr 11 14:00:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819939, encodeId=28b01819939c0, content=<a href='/topic/show?id=644a100144e7' target=_blank style='color:#2F92EE;'>#顾东风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100144, encryptionId=644a100144e7, topicName=顾东风)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b96f328, createdName=wwzzly, createdTime=Wed Dec 01 11:00:29 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293771, encodeId=ed7d1293e71a3, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jun 18 21:00:29 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974308, encodeId=56cd9e430875, content=收获满满, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b95527277, createdName=ms7000001261292141, createdTime=Thu Jun 17 09:51:08 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046073, encodeId=299910460e3f3, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Jun 17 09:00:29 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
    2022-04-11 syscxl
  7. 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encryptionId=fc4e9e348b6, topicName=阜外医)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Jul 16 08:00:29 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949773, encodeId=878a1949e7310, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Mon Sep 13 00:00:29 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754462, encodeId=977f1e5446253, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Mon Apr 11 14:00:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819939, encodeId=28b01819939c0, content=<a href='/topic/show?id=644a100144e7' target=_blank style='color:#2F92EE;'>#顾东风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100144, encryptionId=644a100144e7, topicName=顾东风)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b96f328, createdName=wwzzly, createdTime=Wed Dec 01 11:00:29 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293771, encodeId=ed7d1293e71a3, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jun 18 21:00:29 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974308, encodeId=56cd9e430875, content=收获满满, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b95527277, createdName=ms7000001261292141, createdTime=Thu Jun 17 09:51:08 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046073, encodeId=299910460e3f3, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Jun 17 09:00:29 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
    2021-12-01 wwzzly
  8. [GetPortalCommentsPageByObjectIdResponse(id=2001360, encodeId=5215200136095, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed May 11 08:00:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632086, encodeId=52b8163208685, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encryptionId=fc4e9e348b6, topicName=阜外医)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Fri Jul 16 08:00:29 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949773, encodeId=878a1949e7310, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Mon Sep 13 00:00:29 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754462, encodeId=977f1e5446253, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Mon Apr 11 14:00:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819939, encodeId=28b01819939c0, content=<a href='/topic/show?id=644a100144e7' target=_blank style='color:#2F92EE;'>#顾东风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100144, encryptionId=644a100144e7, topicName=顾东风)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b96f328, createdName=wwzzly, createdTime=Wed Dec 01 11:00:29 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293771, encodeId=ed7d1293e71a3, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jun 18 21:00:29 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974308, encodeId=56cd9e430875, content=收获满满, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b95527277, createdName=ms7000001261292141, createdTime=Thu Jun 17 09:51:08 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046073, encodeId=299910460e3f3, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Jun 17 09:00:29 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2001360, encodeId=5215200136095, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed May 11 08:00:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632086, encodeId=52b8163208685, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a1a21855288, createdName=lq0308, createdTime=Mon Nov 22 01:00:29 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704511, encodeId=1ae61e045114e, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Oct 07 13:00:29 CST 2021, time=2021-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816176, encodeId=dd6418161e6c6, content=<a href='/topic/show?id=fc4e9e348b6' target=_blank style='color:#2F92EE;'>#阜外医#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97348, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Mon Apr 11 14:00:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819939, encodeId=28b01819939c0, content=<a href='/topic/show?id=644a100144e7' target=_blank style='color:#2F92EE;'>#顾东风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100144, encryptionId=644a100144e7, topicName=顾东风)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b96f328, createdName=wwzzly, createdTime=Wed Dec 01 11:00:29 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293771, encodeId=ed7d1293e71a3, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jun 18 21:00:29 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974308, encodeId=56cd9e430875, content=收获满满, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b95527277, createdName=ms7000001261292141, createdTime=Thu Jun 17 09:51:08 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046073, encodeId=299910460e3f3, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Jun 17 09:00:29 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
    2021-06-17 ms7000001261292141

    收获满满

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2001360, encodeId=5215200136095, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed May 11 08:00:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632086, encodeId=52b8163208685, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Mon Apr 11 14:00:29 CST 2022, time=2022-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819939, encodeId=28b01819939c0, content=<a href='/topic/show?id=644a100144e7' target=_blank style='color:#2F92EE;'>#顾东风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100144, encryptionId=644a100144e7, topicName=顾东风)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b96f328, createdName=wwzzly, createdTime=Wed Dec 01 11:00:29 CST 2021, time=2021-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293771, encodeId=ed7d1293e71a3, content=<a href='/topic/show?id=4c6e9e34931' target=_blank style='color:#2F92EE;'>#阜外医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97349, encryptionId=4c6e9e34931, topicName=阜外医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jun 18 21:00:29 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974308, encodeId=56cd9e430875, content=收获满满, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b95527277, createdName=ms7000001261292141, createdTime=Thu Jun 17 09:51:08 CST 2021, time=2021-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046073, encodeId=299910460e3f3, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Jun 17 09:00:29 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
    2021-06-17 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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