J Dent Res:恢复健康口腔微生物群:防止生态失调的机制

2017-12-04 lishiting MedSci原创

现今,牙齿疾病可以被视为正常稳定口腔微生物的失衡引起的有害变化的后果。众所周知,频繁的碳水化合物的摄入以及口腔唾液的减少会导致龋齿,并且过度的菌斑累积会增加牙周病的风险。然而,当这些引起疾病的因素存在时,一些个体表现为易敏,另一些表现为更加耐受或从遭受口腔微生物不良改变后恢复过来。

现今,牙齿疾病可以被视为正常稳定口腔微生物的失衡引起的有害变化的后果。众所周知,频繁的碳水化合物的摄入以及口腔唾液的减少会导致龋齿,并且过度的菌斑累积会增加牙周病的风险。然而,当这些引起疾病的因素存在时,一些个体表现为易敏,另一些表现为更加耐受或从遭受口腔微生物不良改变后恢复过来。维持健康的机制是限制疾病因素的影响,包括在牙齿生物膜以及生物膜与宿主之间的一系列复杂的代谢和功能的相互关系。相反,在这些微生物菌落中会发生正反馈回路,它会阻碍菌群的恢复,并唤起生态系统功能和结构上巨大和突然的改变(微生物的"政权转移"),进而导致生态失调和口腔疾病的发生。例如:碳水化合物的发酵或炎症导致的酸化在一系列自我强化的事件中会使菌斑累积而分别形成致龋或致尖周病的小生物菌群。相反,在耐受个体中,维持健康的机制包括对致病因素的负反馈、能够维持恢复状态和提高抵抗并从致病因素中恢复过来。近期对维持健康机制的研究包括氨产物、限制致龋的pH降低和抑制多阶段疾病相关的正反馈回路的反酸化作用。通过比较微生物和其相互作用与易敏和耐受宿主的组学研究能够检测到菌群恢复的标志物。中和及抑制致病因素,以及鉴定和上调促进健康种属

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    2017-12-10 jihuaijun1112

    学习学习学习

    0

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    2017-12-07 wzb521zf

    一起学习一下

    0

  4. 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    2017-12-07 120ecc2bm88暂无昵称

    好!

    0

  5. 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  6. 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    2017-12-05 执着追梦

    学习.谢谢分享

    0

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    2017-12-05 jihuaijun1112

    学习学习学习

    0

  8. 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    2017-12-05 swfzhanggui

    人体微生物.越来越奇妙.

    0

  9. 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    2017-12-04 131****2916

    不错的文章值得推荐一下

    0

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    2017-12-04 有备才能无患

    维持健康的机制是限制疾病因素的影响.包括在牙齿生物膜以及生物膜与宿主之间的一系列复杂的代谢和功能的相互关系.

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