Nat Commun:非肥胖性非酒精性脂肪肝中肠道微生物组与肝纤维化显著相关

2020-10-19 xiaozeng MedSci原创

非酒精性脂肪肝病(NAFLD)的特征表现为代谢紊乱,包括单纯性脂肪变性和非酒精性脂肪肝炎(NASH),最终会导致晚期肝纤维化和肝硬化。在大多数流行病学研究中,NAFLD的全球患病率约为24%至30%,

非酒精性脂肪肝病(NAFLD)的特征表现为代谢紊乱,包括单纯性脂肪变性和非酒精性脂肪肝炎(NASH),最终会导致晚期肝纤维化和肝硬化。在大多数流行病学研究中,NAFLD的全球患病率约为24%至30%,且与肥胖症和代谢综合征平行增加。

尽管NAFLD通常与肥胖相关,但在非肥胖受试者中也出现NAFLD,其病情的严重程度与肥胖性NAFLD患者相似。尽管内脏脂肪率、饮食组成和遗传因素等均与非肥胖性NAFLD相关,但仍需要考虑其他环境因素来阐明非肥胖性NAFLD的发病机理。

非肥胖/肥胖受试者肠道微生物多样性比较

该研究旨在采用16S rRNA测序技术,分析171例亚洲NAFLD样本和31个非NAFLD对照样本的肠道微生物组谱,并在独立的西方队列中进行外部验证。根据NAFLD的组织学谱系或纤维化的严重程度将受试者分为三个亚组。研究人员发现,非肥胖受试者中微生物组多样性的显著变化与纤维化的严重程度相关。

非肥胖/肥胖受试者微生物类群和粪便代谢物成分的分布网络比较

在非肥胖受试者中,瘤胃菌科(Ruminococcaceae)和韦荣氏菌科(Veillonellaceae)是与纤维化严重程度相关的主要微生物菌群。此外,受试者中,特别是具有明显纤维化的非肥胖受试者中,粪便胆汁酸和丙酸盐的水平升高。对纤维化相关的上述两个微生物菌群进行宏基因组测序,并在三个NAFLD小鼠模型中评估四个代表性菌种对肝脏损伤的影响。

宏基因组分析非肥胖受试者中纤维化相关微生物菌群

综上,该研究结果揭示了微生物组在肝纤维化发病机制中的作用,尤其是在非肥胖受试者中。


原始出处:

Lee, G., You, H.J., Bajaj, J.S. et al. Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD. Nat Commun 11, 4982 (05 October 2020).

 

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    2021-05-19 liye789132251
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893289, encodeId=d8f289328996, content=该研究结果揭示了微生物组在肝纤维化发病机制中的作用,尤其是在非肥胖受试者中。肠道菌群为王,无论肥胖或不肥胖,如果肠道菌群不健康,都有可能患有非酒精性脂肪肝病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:21:49 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
  5. 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  6. 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  7. 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channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Dec 17 03:51:54 CST 2020, time=2020-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087807, encodeId=a4e8208e8075e, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Wed Jul 07 18:51:54 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382451, encodeId=03e31382451aa, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Oct 21 14:51:54 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461630, encodeId=15a3146163077, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Wed Oct 21 14:51:54 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893289, encodeId=d8f289328996, content=该研究结果揭示了微生物组在肝纤维化发病机制中的作用,尤其是在非肥胖受试者中。肠道菌群为王,无论肥胖或不肥胖,如果肠道菌群不健康,都有可能患有非酒精性脂肪肝病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:21:49 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2021-07-07 liuli5079
  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893289, encodeId=d8f289328996, content=该研究结果揭示了微生物组在肝纤维化发病机制中的作用,尤其是在非肥胖受试者中。肠道菌群为王,无论肥胖或不肥胖,如果肠道菌群不健康,都有可能患有非酒精性脂肪肝病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:21:49 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893289, encodeId=d8f289328996, content=该研究结果揭示了微生物组在肝纤维化发病机制中的作用,尤其是在非肥胖受试者中。肠道菌群为王,无论肥胖或不肥胖,如果肠道菌群不健康,都有可能患有非酒精性脂肪肝病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:21:49 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
  10. 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channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Dec 17 03:51:54 CST 2020, time=2020-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087807, encodeId=a4e8208e8075e, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Wed Jul 07 18:51:54 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382451, encodeId=03e31382451aa, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Oct 21 14:51:54 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461630, encodeId=15a3146163077, content=<a href='/topic/show?id=7ccf816e335' target=_blank style='color:#2F92EE;'>#肠道微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81673, encryptionId=7ccf816e335, topicName=肠道微生物组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6316431503, createdName=snf701209, createdTime=Wed Oct 21 14:51:54 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893289, encodeId=d8f289328996, content=该研究结果揭示了微生物组在肝纤维化发病机制中的作用,尤其是在非肥胖受试者中。肠道菌群为王,无论肥胖或不肥胖,如果肠道菌群不健康,都有可能患有非酒精性脂肪肝病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:21:49 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2020-10-20 Jessica

    该研究结果揭示了微生物组在肝纤维化发病机制中的作用,尤其是在非肥胖受试者中。肠道菌群为王,无论肥胖或不肥胖,如果肠道菌群不健康,都有可能患有非酒精性脂肪肝病。

    0

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