呼吸病学遇到睡眠医学2018-2019:CTS 2019

2019-09-07 hosttest MedSci原创

由中华医学会和中华医学会呼吸病学分会主办、湖北省医学会承办的中华医学会呼吸病学年会-2019(第二十次全国呼吸病学学术会议)于2019年9月5日-8日在武汉盛大召开。上海交通大学医学院呼吸病研究所李庆云教授做了呼吸病学遇到睡眠医学2018-2019的主题报告,在此小编整理与大家分享。全面认识睡眠呼吸障碍疾病谱呼吸系统疾病与睡眠呼吸暂停慢性气道疾病难治性哮喘频发的危险因素,OA患者合并日间嗜睡(ES

由中华医学会和中华医学会呼吸病学分会主办、湖北省医学会承办的中华医学会呼吸病学年会-2019(第二十次全国呼吸病学学术会议)于2019年9月5日-8日在武汉盛大召开。



上海交通大学医学院呼吸病研究所李庆云教授做了呼吸病学遇到睡眠医学2018-2019的主题报告,在此小编整理与大家分享。

全面认识睡眠呼吸障碍疾病谱





呼吸系统疾病与睡眠呼吸暂停



慢性气道疾病

OA患者合并日间嗜睡(ESS>11):加重疾病负担。
OSA合并哮喘:睡眠质量差;和严重的夜间低氧血症相关
CPAP治疗哮喘合并OSA:1.夜间哮喘症状明显改善;2. 改善患者的睡眠状况;3. 提高生活质量
OSA-COPD 重叠综合征:研究显示,与单纯COPD相比,OVS患者患者每天减少672步;OVS患者CRP和Il-6水平显著升高;OVS患者每少走1000步,IL-6增加0.875ng/mL。另一项研究显示,COPD(HR=1.5)及COPD+OSA(HR=2.4)显著提高全程死亡率。

此外,与睡眠呼吸相关的慢性气道疾病还包括囊性纤维化、CF、慢性咳嗽等。

血管

一.OSA与肺栓塞:



二.OSA与肺动脉高压:REM期肺动脉压上升更显著;REM消失后立即恢复至初始水平。

危重症

急性呼吸衰竭临床特点:
同期衰竭的出现发生较快:二氧化碳水平明显提高,可伴有昏迷;常见于过度肥胖、颈短,咽部软组织堆积者;针对性治疗后,恢复的速度较COPD合并呼吸衰竭要快;无创呼吸机治疗。

肺间质疾病

研究显示,88%IPF(44/50)患者存在OSA。IPF合并OSA可能机制:
1.IPF及OSA与食管返流均相关; 2. 肺容积缩小,咽腔的横截面积缩小。

肺部肿瘤

OSA与癌症发生率
IH与黑色素瘤肺转移:IH通过炎症反应和氧化应激促进黑色素瘤转移。

烟草病学

睡眠及OSA和吸烟交互影响:吸烟影响生理节律;失眠加重吸烟行为;吸烟和睡眠行为存在基因相关性。
睡眠呼吸障碍和吸烟具有性别差异:



呼吸系统疾病与失眠

一.OSA与失眠症:
OSA与失眠症相互促进,如下图所示:



对失眠合并OSA的治疗:
认知行为治疗:CBTi改善睡眠质量,减少日间功能障碍;
镇静催眠药治疗:非苯二氮卓类药物改善睡眠质量,不增加OSA患者风险;
联合治疗安眠药/CBTi + PAP/手术疗效更佳,睡眠质量改善更显著。    

二.COPD与失眠症:



危险因素有吸烟、忧伤、焦虑,氧疗有助于减少失眠。使用罗氟司特治疗使COPD患者失眠风险更高。     

对COPD合并失眠症的治疗:
1. 积极治疗原发病及合并症:吸氧、支气管扩张剂等
2. 合理使用镇静安眠药:褪黑素受体激动剂雷美替胺
3. 认知行为治疗:睡眠限制,放松训练及睡眠卫生等     

三.支气管哮喘与失眠症:

合并失眠的哮喘患者疾病风险更高



对支气管哮喘合并失眠的治疗:
1. 积极治疗哮喘合并症:规范使用支气管扩张剂控制症状,积极治疗慢性鼻炎及GERD等;
2. 镇静催眠药:BZDs及唑吡坦可增加哮喘急性发作及死亡风险,其它失眠药物尚缺乏支持证据。

总结:
认识:睡眠呼吸障碍疾病谱;
关注:呼吸系统疾病与睡眠呼吸暂停;
探索:呼吸系统疾病与失眠问题。

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    2019-09-08 docwu2019
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    2019-09-07 yjs木玉

    好好好好好好

    0

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    2019-09-07 184****9840

    学习了,谢谢分享

    0

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