JACC:肠道菌群代谢物水平与冠心病风险密切相关

2020-02-25 不详 MedSci原创

肠道微生物代谢产物三甲胺氮氧化物(TMAO)与冠状动脉粥样硬化有关,目前尚无前瞻性研究TMAO长期的变化与冠心病发生的相关性。本研究的目的旨在评估10年的血浆TMAO变化与冠心病发生的相关性。本研究在基线水平纳入了760名健康女性,血浆TMAO分别在第一次(1989-1990)和第二次(2000-2002)采血时检测,结果发现尽管基础TMAO水平各异,但是10年的TAMO增加水平与冠心病风险增加密

肠道微生物代谢产物三甲胺氮氧化物(TMAO)与冠状动脉粥样硬化有关,目前尚无前瞻性研究TMAO长期的变化与冠心病发生的相关性。本研究的目的旨在评估10年的血浆TMAO变化与冠心病发生的相关性。

本研究在基线水平纳入了760名健康女性,血浆TMAO分别在第一次(1989-1990)和第二次(2000-2002)采血时检测,结果发现尽管基础TMAO水平各异,但是10年的TAMO增加水平与冠心病风险增加密切相关,两次采血时TMAO都处于高水平的参与者冠心病发生的风险也最高。另外,TAMO与冠心病的相关性在不健康饮食的情况下会更强。

研究结果显示,长期的TMAO变化与冠心病的发生密切相关,且饮食习惯会参与这种相关性。

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    2020-06-13 hbwxf
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