IBD:炎症性肠病的疾病活动度与动脉血管疾病的发生有关

2020-07-16 MedSci原创 MedSci原创

有证据表明,炎症性疾病与心血管风险增加有关。本项研究旨在评估这种风险,并针对常规血管危险因素和IBD疾病活动的影响进行验证。

背景和目标:

有证据表明,炎症性疾病与血管风险增加有关。本项研究旨在评估这种风险,并针对常规血管危险因素和IBD疾病活动的影响进行验证。

 

方法:

研究人员对来自英国临床实践研究数据链的合格患者进行了队列研究。他们提取了1997年至2017年患有IBD并与对照组匹配的受试者的临床记录,进行了Cox比例风险和自控病例系列分析,以检查IBD,疾病活动性和住院与心肌梗塞,中风和心肌梗死的风险之间的关系。并试图消除可能造成混淆的影响的心血管死亡。

 

结果:

本项研究共确定了31175例IBD患者(16779例UC,10721例克罗恩病和3675例无法分类的IBD)和154412例匹配的对照组。在IBD病例中观察到523例心肌梗塞,555例中风和469例心血管死亡。Cox回归模型(针对潜在的混杂因素进行了调整)显示,总体而言,IBD患者的血管事件没有明显过量。然而,非卧床患者对急性疾病(危险比,1.83 [1.28–2.62])和慢性活动(危险比,1.69 [1.24–2.30])的危险增加。

 

结论:

尽管本项研究没有发现IBD患者总体血管事件过多的证据,但是研究人员发现活动性疾病会导致心血管疾病风险增加,抗炎治疗可能降低该患者组的心血管风险。

 

原始出处:

Timothy R Card. Et al. Disease Activity in Inflammatory Bowel Disease Is Associated With Arterial Vascular Disease. Inflammatory Bowel Diseases.2020.

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    2020-07-18 bnurmamat
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该研究为孤独与心血管事件之间的关系提供了有力的证据。在心血管疾病的研究和干预措施中,孤独感应被视为CVD的社会心理危险因素。

Ann Rheum Dis:类风湿性关节炎对冠心病和非冠心病患者主要心血管事件的影响

在接受CAG的患者中,无论是否存在CAD,RA均与MI、MACE和全因死亡率的10年风险显著相关。

Heart:孤独、社会孤立与心血管事件之间的纵向联系

该研究的结果为孤独与心血管事件之间的关系提供了有力的证据。在研究和预防心血管疾病的干预措施中,应将孤独视为心血管疾病的社会心理危险因素。