NEJM:干燥综合征患者干燥性角结膜炎-病例报道

2020-10-22 MedSci原创 MedSci原创

该患者被诊断为干燥综合征,眼部症状的局部治疗包括环孢霉素A和人工泪液。

患者为一名64岁的女性,因双眼畏光伴有眼痛和异物感5个月而到风湿科就诊。在进一步询问时,患者报告说她有眼睛干涩和口干大约20年,没有进行具体的诊断或治疗。

患者每只眼睛的视力为20/25,裂隙灯检查发现结膜充血,角膜上皮糜烂和角膜内皮折叠均与干燥性角膜结膜炎一致(如图A和B所示)。通过荧光染色进一步观察角膜病变(如图C和D所示 [绿色区域])。Schirmer检查发现泪液产生减少,血清学检查发现抗核抗体效价为1:160,Sjögren综合征相关抗原A(Ro52)的抗体呈阳性,并且类风湿因子升高至66 IU/ml(参考值<20 IU/ml)。

该患者被诊断为干燥综合征,眼部症状的局部治疗包括环孢霉素A和人工泪液。

2个月后患者的症状消失。

原始出处:

Yutong Su,et al.Keratoconjunctivitis Sicca in Sjögren’s Syndrome.N Engl J Med 2020;https://www.nejm.org/doi/full/10.1056/NEJMicm1910311

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    2020-10-22 旺医

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