Hepatology:脂肪细胞分泌因子抵抗素诱导肝脂肪变性的分子机制

2013-02-07 何嫱 Hepatology

来自华中农业大学生命技术学院和德国糖尿病中心的研究人员在新研究中揭示了脂肪细胞分泌因子抵抗素(Resistin)诱导肝脂肪变性的分子机制,相关论文于1月25日发表在国际著名肝脏疾病杂志Hepatology(最新影响因子11.665)上。 领导这一研究的是华中农业大学生命技术学院的杨在清(Zaiqing Yang)教授,其主要研究方向包括脂肪细胞因子,脂肪沉积的分子机理,脂肪细胞分化与代谢,脂肪细

来自华中农业大学生命技术学院和德国糖尿病中心的研究人员在新研究中揭示了脂肪细胞分泌因子抵抗素(Resistin)诱导肝脂肪变性的分子机制,相关论文于1月25日发表在国际著名肝脏疾病杂志Hepatology(最新影响因子11.665)上。

领导这一研究的是华中农业大学生命技术学院的杨在清(Zaiqing Yang)教授,其主要研究方向包括脂肪细胞因子,脂肪沉积的分子机理,脂肪细胞分化与代谢,脂肪细胞功能基因组以及动物基因的表达调控与信号传导。学术刊物上发表学术论文80余篇。

肥胖是现代工业社会的一种流行病,它导致胰岛素、糖和血脂的血液水平的混乱,而这些问题又会引发高血压、Ⅱ型糖尿病和脂肪肝。肥胖还能增加不同类型癌症的风险。目前,越来越多的人们受到肥胖及相关的慢性疾病的困扰。然而到目前为止,对于肥胖导致糖尿病、脂肪肝和血脂问题的分子机制仍了解甚少,阐明这些过程的确切机制对于预防及改善这些疾病的治疗具有重要的意义。

Resistin是抵抗素样分子家族成员之一,是由脂肪细胞分泌的、富含半胱氨酸的细胞因子。研究人员曾证实,啮齿类动物体内的resistin有诱导胰岛素抵抗的作用。近来,越来越多的研究表明resistin与肥胖、胰岛素抵抗、2型糖尿病、心血管疾病等机体多种疾病相关。

在这篇新文章中,研究人员通过小鼠实验发现:Resistin下调了线粒体的数量和活性,促进了肝脂肪变性,诱导了胰岛素抵抗(IR)。这一时间进程表明,在脂肪沉积改变及胰岛素抵抗形成前便已有线粒体数量改变。当线粒体数量稳定之时,Resistin不会刺激肝脂肪沉积。采用突变研究,研究人员证实核因子κB(NF-κB)p65亚基的Thr464残基对线粒体调控至关重要。邻位连接分析(proximity ligation assay , PLA)结果揭示,resistin通过促进p65和PGC-1α互作,导致了PGC-1α失活以及线粒体数量减少。信号转导分析证实Resistin通过新的PKC-PKG-p65-PGC-1α信号下调了线粒体。

研究结果表明Resistin通过减少线粒体数量诱导了肝脂肪变性。新研究揭示了线粒体调控的一条新信号通路,表明维持正常线粒体含量有可能是肥胖相关疾病的一种新治疗策略。

DOI: 10.1002/hep.26167
PMC:
PMID:

Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway

Lei Zhou1,*, Xiaolan Yu1, Qingjie Meng1,Hongqiang Li1, Congcong Niu1, Yun Jiang1, Yuxi Cai1, Minghui Li1, Qiang Li1, Chaoqiang An1, Le Shu1, Ao Chen1, Handong Su1, Yin Tang1, Shen Yin1, Silja Raschke2, Kristin Eckardt2, Jürgen Eckel2, Zaiqing Yang1,‡,

Obesity is associated with many severe chronic diseases and deciphering its development and molecular mechanisms is necessary for promoting treatment. Previous studies have revealed that mitochondrial content is down-regulated in obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD) and proposed that NAFLD and diabetes are mitochondrial diseases. However, the exact mechanisms underlying these processes remain unclear. In this study, we discovered that resistin down-regulated the content and activities of mitochondria, enhanced hepatic steatosis, and induced insulin resistance (IR) in mice. The time course indicated that the change in mitochondrial content was before the change in fat accumulation and development of insulin resistance. When the mitochondrial content was maintained, resistin did not stimulate hepatic fat accumulation. The present mutation study found that the residue Thr464 of the p65 subunit of nuclear factor kappa B was essential for regulating mitochondria. A proximity ligation assay revealed that resistin inactivated peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC-1α) and diminished the mitochondrial content by promoting the interaction of p65 and PGC-1α. Signaling-transduction analysis demonstrated that resistin down-regulated mitochondria by a novel protein kinase C/protein kinase G/p65/PGC-1α-signaling pathway. Conclusion: Resistin induces hepatic steatosis through diminishing mitochondrial content. This reveals a novel pathway for mitochondrial regulation, and suggests that the maintenance of normal mitochondrial content could be a new strategy for treatment of obesity-associated diseases.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1948754, encodeId=ed031948e548e, content=<a href='/topic/show?id=0602843360f' target=_blank style='color:#2F92EE;'>#脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84336, encryptionId=0602843360f, topicName=脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 12:33:00 CST 2013, time=2013-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682135, encodeId=b95e1682135f0, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 08 12:33:00 CST 2013, time=2013-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743237, encodeId=402d1e43237c4, content=<a href='/topic/show?id=74fc81413e3' target=_blank style='color:#2F92EE;'>#肝脂肪变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81413, encryptionId=74fc81413e3, topicName=肝脂肪变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=531535069436, createdName=10518105zz, createdTime=Tue May 28 07:33:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400875, encodeId=bae114008e519, content=<a href='/topic/show?id=8fde8438079' target=_blank style='color:#2F92EE;'>#脂肪细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84380, encryptionId=8fde8438079, topicName=脂肪细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77712282976, createdName=shenxlcyp, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426523, encodeId=ccbd1426523e7, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463467, encodeId=8ae3146346e3d, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489646, encodeId=69cd1489646d3, content=<a href='/topic/show?id=da2e81414f8' target=_blank style='color:#2F92EE;'>#肝脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81414, encryptionId=da2e81414f8, topicName=肝脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2afd8580003, createdName=whlxd, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1948754, encodeId=ed031948e548e, content=<a href='/topic/show?id=0602843360f' target=_blank style='color:#2F92EE;'>#脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84336, encryptionId=0602843360f, topicName=脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 12:33:00 CST 2013, time=2013-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682135, encodeId=b95e1682135f0, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 08 12:33:00 CST 2013, time=2013-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743237, encodeId=402d1e43237c4, content=<a href='/topic/show?id=74fc81413e3' target=_blank style='color:#2F92EE;'>#肝脂肪变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81413, encryptionId=74fc81413e3, topicName=肝脂肪变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=531535069436, createdName=10518105zz, createdTime=Tue May 28 07:33:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400875, encodeId=bae114008e519, content=<a href='/topic/show?id=8fde8438079' target=_blank style='color:#2F92EE;'>#脂肪细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84380, encryptionId=8fde8438079, topicName=脂肪细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77712282976, createdName=shenxlcyp, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426523, encodeId=ccbd1426523e7, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463467, encodeId=8ae3146346e3d, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489646, encodeId=69cd1489646d3, content=<a href='/topic/show?id=da2e81414f8' target=_blank style='color:#2F92EE;'>#肝脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81414, encryptionId=da2e81414f8, topicName=肝脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2afd8580003, createdName=whlxd, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=)]
    2013-04-08 zhaojie88
  3. [GetPortalCommentsPageByObjectIdResponse(id=1948754, encodeId=ed031948e548e, content=<a href='/topic/show?id=0602843360f' target=_blank style='color:#2F92EE;'>#脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84336, encryptionId=0602843360f, topicName=脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 12:33:00 CST 2013, time=2013-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682135, encodeId=b95e1682135f0, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 08 12:33:00 CST 2013, time=2013-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743237, encodeId=402d1e43237c4, content=<a href='/topic/show?id=74fc81413e3' target=_blank style='color:#2F92EE;'>#肝脂肪变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81413, encryptionId=74fc81413e3, topicName=肝脂肪变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=531535069436, createdName=10518105zz, createdTime=Tue May 28 07:33:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400875, encodeId=bae114008e519, content=<a href='/topic/show?id=8fde8438079' target=_blank style='color:#2F92EE;'>#脂肪细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84380, encryptionId=8fde8438079, topicName=脂肪细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77712282976, createdName=shenxlcyp, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426523, encodeId=ccbd1426523e7, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463467, encodeId=8ae3146346e3d, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489646, encodeId=69cd1489646d3, content=<a href='/topic/show?id=da2e81414f8' target=_blank style='color:#2F92EE;'>#肝脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81414, encryptionId=da2e81414f8, topicName=肝脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2afd8580003, createdName=whlxd, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1948754, encodeId=ed031948e548e, content=<a href='/topic/show?id=0602843360f' target=_blank style='color:#2F92EE;'>#脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84336, encryptionId=0602843360f, topicName=脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 12:33:00 CST 2013, time=2013-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682135, encodeId=b95e1682135f0, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 08 12:33:00 CST 2013, time=2013-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743237, encodeId=402d1e43237c4, content=<a href='/topic/show?id=74fc81413e3' target=_blank style='color:#2F92EE;'>#肝脂肪变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81413, encryptionId=74fc81413e3, topicName=肝脂肪变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=531535069436, createdName=10518105zz, createdTime=Tue May 28 07:33:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400875, encodeId=bae114008e519, content=<a href='/topic/show?id=8fde8438079' target=_blank style='color:#2F92EE;'>#脂肪细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84380, encryptionId=8fde8438079, topicName=脂肪细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77712282976, createdName=shenxlcyp, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426523, encodeId=ccbd1426523e7, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463467, encodeId=8ae3146346e3d, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489646, encodeId=69cd1489646d3, content=<a href='/topic/show?id=da2e81414f8' target=_blank style='color:#2F92EE;'>#肝脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81414, encryptionId=da2e81414f8, topicName=肝脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2afd8580003, createdName=whlxd, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1948754, encodeId=ed031948e548e, content=<a href='/topic/show?id=0602843360f' target=_blank style='color:#2F92EE;'>#脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84336, encryptionId=0602843360f, topicName=脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 12:33:00 CST 2013, time=2013-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682135, encodeId=b95e1682135f0, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 08 12:33:00 CST 2013, time=2013-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743237, encodeId=402d1e43237c4, content=<a href='/topic/show?id=74fc81413e3' target=_blank style='color:#2F92EE;'>#肝脂肪变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81413, encryptionId=74fc81413e3, topicName=肝脂肪变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=531535069436, createdName=10518105zz, createdTime=Tue May 28 07:33:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400875, encodeId=bae114008e519, content=<a href='/topic/show?id=8fde8438079' target=_blank style='color:#2F92EE;'>#脂肪细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84380, encryptionId=8fde8438079, topicName=脂肪细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77712282976, createdName=shenxlcyp, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426523, encodeId=ccbd1426523e7, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463467, encodeId=8ae3146346e3d, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489646, encodeId=69cd1489646d3, content=<a href='/topic/show?id=da2e81414f8' target=_blank style='color:#2F92EE;'>#肝脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81414, encryptionId=da2e81414f8, topicName=肝脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2afd8580003, createdName=whlxd, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=)]
    2013-02-09 gwc384
  6. [GetPortalCommentsPageByObjectIdResponse(id=1948754, encodeId=ed031948e548e, content=<a href='/topic/show?id=0602843360f' target=_blank style='color:#2F92EE;'>#脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84336, encryptionId=0602843360f, topicName=脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 12:33:00 CST 2013, time=2013-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682135, encodeId=b95e1682135f0, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 08 12:33:00 CST 2013, time=2013-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743237, encodeId=402d1e43237c4, content=<a href='/topic/show?id=74fc81413e3' target=_blank style='color:#2F92EE;'>#肝脂肪变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81413, encryptionId=74fc81413e3, topicName=肝脂肪变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=531535069436, createdName=10518105zz, createdTime=Tue May 28 07:33:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400875, encodeId=bae114008e519, content=<a href='/topic/show?id=8fde8438079' target=_blank style='color:#2F92EE;'>#脂肪细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84380, encryptionId=8fde8438079, topicName=脂肪细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77712282976, createdName=shenxlcyp, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426523, encodeId=ccbd1426523e7, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463467, encodeId=8ae3146346e3d, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489646, encodeId=69cd1489646d3, content=<a href='/topic/show?id=da2e81414f8' target=_blank style='color:#2F92EE;'>#肝脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81414, encryptionId=da2e81414f8, topicName=肝脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2afd8580003, createdName=whlxd, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=)]
    2013-02-09 huangdf
  7. [GetPortalCommentsPageByObjectIdResponse(id=1948754, encodeId=ed031948e548e, content=<a href='/topic/show?id=0602843360f' target=_blank style='color:#2F92EE;'>#脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84336, encryptionId=0602843360f, topicName=脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 12:33:00 CST 2013, time=2013-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682135, encodeId=b95e1682135f0, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 08 12:33:00 CST 2013, time=2013-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743237, encodeId=402d1e43237c4, content=<a href='/topic/show?id=74fc81413e3' target=_blank style='color:#2F92EE;'>#肝脂肪变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81413, encryptionId=74fc81413e3, topicName=肝脂肪变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=531535069436, createdName=10518105zz, createdTime=Tue May 28 07:33:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400875, encodeId=bae114008e519, content=<a href='/topic/show?id=8fde8438079' target=_blank style='color:#2F92EE;'>#脂肪细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84380, encryptionId=8fde8438079, topicName=脂肪细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77712282976, createdName=shenxlcyp, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426523, encodeId=ccbd1426523e7, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463467, encodeId=8ae3146346e3d, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489646, encodeId=69cd1489646d3, content=<a href='/topic/show?id=da2e81414f8' target=_blank style='color:#2F92EE;'>#肝脂肪变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81414, encryptionId=da2e81414f8, topicName=肝脂肪变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2afd8580003, createdName=whlxd, createdTime=Sat Feb 09 05:33:00 CST 2013, time=2013-02-09, status=1, ipAttribution=)]

相关资讯

PNAS:偶然突变的积累能减缓癌症发展

一个典型的癌细胞基因组中分散着成千上万的突变,有着数以百计的突变基因.然而,这些突变基因中只有一小部分被认为是癌症的驱动子,负责癌症特征的表现,例如不受控制的细胞生长.癌症生物学家们很大程度上忽略了其他突变,因为他们相信那些突变对癌症的进展发挥着微小的作用,甚至乎没有作用. 但是由麻省理工学院(MIT)、哈佛大学、Broad研究所和布莱根妇女医院的一项联合研究首次表明,这些偶然突变(passen

Nature:一氨基酸可显著削弱癌细胞增殖能力

自英国Beatson癌症研究所的研究人员在一项新研究中证实,夺去癌细胞的一种关键氨基酸可显着削弱它们的生长和增殖能力。这一研究发现在线发表在12月16日的《自然》(Nature)杂志上。 Beatson癌症研究所的科学家们研究了当缺乏丝氨酸时癌细胞能够生存并继续生长的机制。细胞通常能够自己生成丝氨酸,然而研究小组发现缺乏p53蛋白的细胞(至少一半的癌症存在这种缺陷)则无法适应这一转变,因此其生长

Oncogene&JBC:解析DNA修复蛋白与癌症复发

就像机体会对抗生素产生抵抗一样,肿瘤细胞也会对特定的抗癌药物产生抵抗。中佛罗里达大学UCF的研究人员发现,在乳腺癌和卵巢癌等数种癌症中出现的KLF8蛋白,是癌细胞抗性和癌症复发的关键。KLF8是一种DNA修复蛋白,研究显示它既能帮助肿瘤细胞抵抗抗癌药物,也能够帮助肿瘤细胞再生。 “所有细胞都有DNA修复机制,”领导这项研究的UCF医学院副教授赵季和(音译:Jihe Zhao)解释道,短短几个月间

Nat Genet :与肠癌相关两个罕见基因突变

英国科学家的一项最新研究发现了两个新的基因。这一研究成果可用来解释,为什么有些家庭非常容易患上肠癌。 科学家发现的这两个基因由父亲或母亲传递给后代,可极大地提高肿瘤形成风险。这项研究发表在新一期的Nature Genetics上,对20位具有家族肠癌史的的20人的DNA进行了分析。 研究成果奖可用来开发新的判断肠癌风险的检测方法。 参与这项实验的一位叫Joe Wiegand的志愿者在28岁的

HMG:吸烟可增加患癌基因活性

香烟留给你的绝对不止衣服和指甲上的呛人气味。一项新的研究找到了有力证据,表明烟草的使用能够在化学上改变和影响那些已知可以增加罹患癌症风险的基因的活性。这项研究或许能够为研究人员提供新的工具,用以评估吸烟人群的癌症风险。 脱氧核糖核酸(DNA)并不是命中注定的。能够影响基因功能的化合物可以与我们的遗传物质结合,从而开启或关闭某些基因。这些所谓的后天修饰能够影响各种各样的特征,例如肥胖和性取向。科学

Nat Genet :三个与大肠癌相关的新遗传“热点”

来自中山大学癌症中心、范德堡大学医学院的研究人员确定了三个与大肠癌相关的新遗传“热点”。研究发现在线发表在12月23日的《自然遗传学》(Nature Genetic)杂志上,从而为我们提供了关于大肠癌生物学的新认识,有可能指出了该疾病新的治疗靶点。 领导这一研究的是华人科学家郑苇(Wei Zheng)教授,其现任范德堡大学Ingram癌症研究中心教授、分子流行病研究室主任,亦为美国NCI基金项目