Laboratory Investigation:GTSE1通过SP1/FOXM1信号通路促进前列腺癌细胞增殖

2021-01-06 AlexYang MedSci原创

G2期/S期应答相关蛋白1 (GTSE1)参与了一些恶性肿瘤的发病机制中。然而,其在前列腺癌(PCa)中的具体作用仍不清楚。

G2期/S期应答相关蛋白1 (GTSE1)参与了一些恶性肿瘤的发病机制中。然而,其在前列腺癌(PCa)中的具体作用仍不清楚。

最近,有研究人员从FIREBROWSE数据库中下载了PCa患者和对照组的RNA-Seq数据,发现GTSE1 mRNA水平在PCa中显著上调。此外,GTSE1 mRNA水平较高的患者有更高的Gleason评分(P<0.001)、更高的pT期(P=0.011)和更高的pN期(P=0.006)以及更短的生化复发时间(P=0.005)。另外,GTSE1的过表达可以促进LNCaP细胞的增殖,而GTSE1沉默可以抑制C4-2细胞在体外和体内的生长。从机制上看,GTSE1通过上调FOXM1的转录因子SP1蛋白水平,增强了FOXM1的表达,最终促进了PCa细胞的增殖。

GTSE1促进前列腺癌细胞的增殖

最后,研究人员指出,GTSE1是PCa发病和进展过程中一个新的候选癌基因,它可以通过SP1/FOXM1信号通路促进PCa细胞增殖

原始出处:

Wenjie Lai, Weian Zhu, Xiaojuan Li et al. GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway. Laboratory Investigation. Dec 2020

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11:12:59 CST 2021, time=2021-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040921, encodeId=0caf10409218c, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Jan 06 23:12:59 CST 2021, time=2021-01-06, status=1, ipAttribution=)]
    2021-01-08 yxch36
  5. 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11:12:59 CST 2021, time=2021-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040921, encodeId=0caf10409218c, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Jan 06 23:12:59 CST 2021, time=2021-01-06, status=1, ipAttribution=)]
    2021-01-08 yibei
  6. 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  7. 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  8. 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11:12:59 CST 2021, time=2021-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040921, encodeId=0caf10409218c, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Jan 06 23:12:59 CST 2021, time=2021-01-06, status=1, ipAttribution=)]
    2021-01-08 闆锋旦
  9. 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    2021-01-06 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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