Neurology :遗传性vs散发性血管瘤,破裂风险哪个高?

2021-10-23 Freeman MedSci原创

家族性UIA的破裂风险是散发性UIA的2.5倍,风险范围是1.2到5倍。

有动脉瘤性蛛网膜下腔出血(aSAH)或未破裂的颅内动脉瘤(UIAs)阳性家族史的人,有10%的风险患有UIA。

有人认为,与没有这种病史的患者相比,这些患者的UIA破裂风险更高。家族性颅内动脉瘤研究报告称,与零星的UIA患者相比,有aSAH家族史加上高血压或吸烟或两者都有的人的破裂率要高17倍。

然而,这些数据缺乏精确性,因为它是基于113名UIAs患者中的两例aSAH。另一个前瞻性的单中心队列,在没有选择吸烟或高血压的情况下,考虑到破裂的危险因素,发现家族性患者的风险要高三倍,这在统计学上没有意义。

阳性家族史的定义也可能对家族性UIA破裂的风险水平起到一定作用。在大多数国家,一级亲属被定义为父母、兄弟姐妹或子女,而在其他一些国家,一级亲属只被定义为父母和子女,而不是兄弟姐妹。

最近研究表明,在家庭内部,兄弟姐妹发生UIA和aSAH的风险比父母和子女高。因此,为了评估家族性动脉瘤破裂的风险,必须将兄弟姐妹纳入一级亲属的范畴。


藉此,荷兰乌特勒支大学的Charlotte CM Zuurbier等人,探究了当把一级亲属定义为父母、兄弟姐妹或子女时,家族性UIA患者比散发性UIA患者有多大程度的破裂风险。其次,评估了在一级亲属定义中包括和不包括兄弟姐妹的队列中的这种关联。

在这个IPD荟萃分析中,他们进行了Embase和Pubmed的搜索,寻找截至2020年12月1日的研究。并纳入了以下研究:1)具有前瞻性研究设计;2)包括50名或更多的UIA患者;3)研究UIA的自然过程和动脉瘤破裂的风险因素,包括动脉瘤蛛网膜下腔出血和UIA的家族史;以及4)将动脉瘤破裂作为结果。有IPD的队列被纳入。

所有的研究都包括了到其中一个研究中心就诊的新诊断的UIA患者。主要结果是动脉瘤破裂。患有多囊性肾病和Moyamoya病的患者被排除在外。

他们使用Cox比例危险回归模型对PHASES评分和吸烟进行调整,比较了家族性UIA与散发性UIA的破裂率。最后,进行了两项分析。1.仅定义一级亲属为父母、子女和兄弟姐妹的研究;2.所有研究,包括那些仅定义一级亲属为父母和子女,而不定义兄弟姐妹的研究。

他们汇集了8个具有低度和中度偏倚风险的队列的IPD。在6个队列中,一级亲属被定义为父母、兄弟姐妹和子女(29%为荷兰人,55%为芬兰人,15%为日本人),共有2297名患者(17%为家族性,399名患者),有3089例UIA,随访7301人年。

10名家族性患者发生破裂(破裂率:0-89%/人-年;95%CI:0-45-1-59),41名散发性患者(0-66%/人-年;95%CI:0-48-0-89);

家族性患者的调整HR为2-56(95%CI:1-18-5-56)。将两个队列中排除兄弟姐妹为一级亲属的患者也加入后,导致9,511名患者的调整HR为1-44(95%CI:0-86-2-40)。

这个研究的重要意义在于发现了:家族性UIA的破裂风险是散发性UIA的2.5倍,风险范围是1.2到5倍。在评估UIA的破裂风险时,应考虑到家族史。



原文出处:
Zuurbier CC, Mensing LA, Wermer MJ, et al. Difference in Rupture Risk Between Familial and Sporadic Intracranial Aneurysms: An Individual Patient Data Meta-analysis. Neurology. Published online October 20, 2021:10.1212/WNL.0000000000012885. doi:10.1212/WNL.0000000000012885

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2041720, encodeId=35d62041e20db, content=<a href='/topic/show?id=9ce4e34862a' target=_blank style='color:#2F92EE;'>#破裂风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73486, encryptionId=9ce4e34862a, topicName=破裂风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sat May 14 00:06:42 CST 2022, time=2022-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043033, encodeId=381820430335a, content=<a href='/topic/show?id=88535e63128' target=_blank style='color:#2F92EE;'>#散发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57631, encryptionId=88535e63128, topicName=散发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Wed Aug 10 20:06:42 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001540, encodeId=c8f820015404c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Oct 03 17:06:42 CST 2022, time=2022-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860157, encodeId=1a9f186015e00, content=<a href='/topic/show?id=cc73951054b' target=_blank style='color:#2F92EE;'>#遗传性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95105, encryptionId=cc73951054b, topicName=遗传性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Dec 29 18:06:42 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348314, encodeId=a136134831497, content=<a href='/topic/show?id=1eaf89e26d3' target=_blank style='color:#2F92EE;'>#血管瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89726, encryptionId=1eaf89e26d3, topicName=血管瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Mon Oct 25 09:06:42 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063498, encodeId=8cc310634987c, content=有人认为,与没有这种病史的患者相比,这些患者的UIA破裂风险更高。家族性颅内动脉瘤研究报告称,与零星的UIA患者相比,有aSAH家族史加上高血压或吸烟或两者都有的人的破裂率要高17倍。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a54e5645039, createdName=ms9000000212834100, createdTime=Sun Oct 24 17:31:44 CST 2021, time=2021-10-24, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2041720, encodeId=35d62041e20db, content=<a href='/topic/show?id=9ce4e34862a' target=_blank style='color:#2F92EE;'>#破裂风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73486, encryptionId=9ce4e34862a, topicName=破裂风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sat May 14 00:06:42 CST 2022, time=2022-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043033, encodeId=381820430335a, content=<a href='/topic/show?id=88535e63128' target=_blank style='color:#2F92EE;'>#散发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57631, encryptionId=88535e63128, topicName=散发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Wed Aug 10 20:06:42 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001540, encodeId=c8f820015404c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Oct 03 17:06:42 CST 2022, time=2022-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860157, encodeId=1a9f186015e00, content=<a href='/topic/show?id=cc73951054b' target=_blank style='color:#2F92EE;'>#遗传性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95105, encryptionId=cc73951054b, topicName=遗传性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Dec 29 18:06:42 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348314, encodeId=a136134831497, content=<a href='/topic/show?id=1eaf89e26d3' target=_blank style='color:#2F92EE;'>#血管瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89726, encryptionId=1eaf89e26d3, topicName=血管瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Mon Oct 25 09:06:42 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063498, encodeId=8cc310634987c, content=有人认为,与没有这种病史的患者相比,这些患者的UIA破裂风险更高。家族性颅内动脉瘤研究报告称,与零星的UIA患者相比,有aSAH家族史加上高血压或吸烟或两者都有的人的破裂率要高17倍。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a54e5645039, createdName=ms9000000212834100, createdTime=Sun Oct 24 17:31:44 CST 2021, time=2021-10-24, status=1, ipAttribution=)]
    2022-08-10 zxxiang
  3. [GetPortalCommentsPageByObjectIdResponse(id=2041720, encodeId=35d62041e20db, content=<a href='/topic/show?id=9ce4e34862a' target=_blank style='color:#2F92EE;'>#破裂风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73486, encryptionId=9ce4e34862a, topicName=破裂风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sat May 14 00:06:42 CST 2022, time=2022-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043033, encodeId=381820430335a, content=<a href='/topic/show?id=88535e63128' target=_blank style='color:#2F92EE;'>#散发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57631, encryptionId=88535e63128, topicName=散发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Wed Aug 10 20:06:42 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001540, encodeId=c8f820015404c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Oct 03 17:06:42 CST 2022, time=2022-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860157, encodeId=1a9f186015e00, content=<a href='/topic/show?id=cc73951054b' target=_blank style='color:#2F92EE;'>#遗传性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95105, encryptionId=cc73951054b, topicName=遗传性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Dec 29 18:06:42 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348314, encodeId=a136134831497, content=<a href='/topic/show?id=1eaf89e26d3' target=_blank style='color:#2F92EE;'>#血管瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89726, encryptionId=1eaf89e26d3, topicName=血管瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Mon Oct 25 09:06:42 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063498, encodeId=8cc310634987c, content=有人认为,与没有这种病史的患者相比,这些患者的UIA破裂风险更高。家族性颅内动脉瘤研究报告称,与零星的UIA患者相比,有aSAH家族史加上高血压或吸烟或两者都有的人的破裂率要高17倍。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a54e5645039, createdName=ms9000000212834100, createdTime=Sun Oct 24 17:31:44 CST 2021, time=2021-10-24, status=1, ipAttribution=)]
    2022-10-03 yinhl1978
  4. [GetPortalCommentsPageByObjectIdResponse(id=2041720, encodeId=35d62041e20db, content=<a href='/topic/show?id=9ce4e34862a' target=_blank style='color:#2F92EE;'>#破裂风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73486, encryptionId=9ce4e34862a, topicName=破裂风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sat May 14 00:06:42 CST 2022, time=2022-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043033, encodeId=381820430335a, content=<a href='/topic/show?id=88535e63128' target=_blank style='color:#2F92EE;'>#散发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57631, encryptionId=88535e63128, topicName=散发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Wed Aug 10 20:06:42 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001540, encodeId=c8f820015404c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Oct 03 17:06:42 CST 2022, time=2022-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860157, encodeId=1a9f186015e00, content=<a href='/topic/show?id=cc73951054b' target=_blank style='color:#2F92EE;'>#遗传性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95105, encryptionId=cc73951054b, topicName=遗传性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Dec 29 18:06:42 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348314, encodeId=a136134831497, content=<a href='/topic/show?id=1eaf89e26d3' target=_blank style='color:#2F92EE;'>#血管瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89726, encryptionId=1eaf89e26d3, topicName=血管瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Mon Oct 25 09:06:42 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063498, encodeId=8cc310634987c, content=有人认为,与没有这种病史的患者相比,这些患者的UIA破裂风险更高。家族性颅内动脉瘤研究报告称,与零星的UIA患者相比,有aSAH家族史加上高血压或吸烟或两者都有的人的破裂率要高17倍。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a54e5645039, createdName=ms9000000212834100, createdTime=Sun Oct 24 17:31:44 CST 2021, time=2021-10-24, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2041720, encodeId=35d62041e20db, content=<a href='/topic/show?id=9ce4e34862a' target=_blank style='color:#2F92EE;'>#破裂风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73486, encryptionId=9ce4e34862a, topicName=破裂风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sat May 14 00:06:42 CST 2022, time=2022-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043033, encodeId=381820430335a, content=<a href='/topic/show?id=88535e63128' target=_blank style='color:#2F92EE;'>#散发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57631, encryptionId=88535e63128, topicName=散发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Wed Aug 10 20:06:42 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001540, encodeId=c8f820015404c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Oct 03 17:06:42 CST 2022, time=2022-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860157, encodeId=1a9f186015e00, content=<a href='/topic/show?id=cc73951054b' target=_blank style='color:#2F92EE;'>#遗传性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95105, encryptionId=cc73951054b, topicName=遗传性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Dec 29 18:06:42 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348314, encodeId=a136134831497, content=<a href='/topic/show?id=1eaf89e26d3' target=_blank style='color:#2F92EE;'>#血管瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89726, encryptionId=1eaf89e26d3, topicName=血管瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Mon Oct 25 09:06:42 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063498, encodeId=8cc310634987c, content=有人认为,与没有这种病史的患者相比,这些患者的UIA破裂风险更高。家族性颅内动脉瘤研究报告称,与零星的UIA患者相比,有aSAH家族史加上高血压或吸烟或两者都有的人的破裂率要高17倍。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a54e5645039, createdName=ms9000000212834100, createdTime=Sun Oct 24 17:31:44 CST 2021, time=2021-10-24, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2041720, encodeId=35d62041e20db, content=<a href='/topic/show?id=9ce4e34862a' target=_blank style='color:#2F92EE;'>#破裂风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73486, encryptionId=9ce4e34862a, topicName=破裂风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sat May 14 00:06:42 CST 2022, time=2022-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043033, encodeId=381820430335a, content=<a href='/topic/show?id=88535e63128' target=_blank style='color:#2F92EE;'>#散发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57631, encryptionId=88535e63128, topicName=散发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Wed Aug 10 20:06:42 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001540, encodeId=c8f820015404c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Oct 03 17:06:42 CST 2022, time=2022-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860157, encodeId=1a9f186015e00, content=<a href='/topic/show?id=cc73951054b' target=_blank style='color:#2F92EE;'>#遗传性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95105, encryptionId=cc73951054b, topicName=遗传性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Wed Dec 29 18:06:42 CST 2021, time=2021-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348314, encodeId=a136134831497, content=<a href='/topic/show?id=1eaf89e26d3' target=_blank style='color:#2F92EE;'>#血管瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89726, encryptionId=1eaf89e26d3, topicName=血管瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Mon Oct 25 09:06:42 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063498, encodeId=8cc310634987c, content=有人认为,与没有这种病史的患者相比,这些患者的UIA破裂风险更高。家族性颅内动脉瘤研究报告称,与零星的UIA患者相比,有aSAH家族史加上高血压或吸烟或两者都有的人的破裂率要高17倍。, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a54e5645039, createdName=ms9000000212834100, createdTime=Sun Oct 24 17:31:44 CST 2021, time=2021-10-24, status=1, ipAttribution=)]
    2021-10-24 ms9000000212834100

    有人认为,与没有这种病史的患者相比,这些患者的UIA破裂风险更高。家族性颅内动脉瘤研究报告称,与零星的UIA患者相比,有aSAH家族史加上高血压或吸烟或两者都有的人的破裂率要高17倍。

    0

相关资讯

J Vasc Surg:20年单中心随访结果,第一代支架腔内修复动脉瘤总体结果

第一代腔内动脉瘤修复支架的问题众所周知,但其长期结果仍有待确定。为探究第一代支架植入(Vanguard)治疗腹主动脉瘤(AAA)患者的预后,来自芬兰的学者分享了单中心长达20年的随访结果。

JNNP:中年人动脉瘤性蛛网膜下腔出血死亡负担相对较高

与其他死因相比,动脉瘤性蛛网膜下腔出血(aSAH)导致的死亡人数通常被认为可以忽略不计。事实上,据估计,蛛网膜下腔出血仅占中风死亡人数的4%。中年人最容易到aSAH的影响。由于癌症、交通、酒精和心血管

NEJM:手部创伤性血管损伤-病例报道

这种血管异常可能是由先天性、感染后或外伤性原因引起的。如果切开不当,则存在大量出血的风险。

JACC:主动脉扩张,有一则容易有二!

任何节段主动脉扩张的最主要预测因素是其他部位的主动脉扩张

动脉瘤破裂命悬一线,医生惊险“拆弹”!忠告:彩超+自查可早发现

腹主动脉瘤就像人体内的一个不定时炸弹,随时都有可能破裂,破裂后的病死率高达90%。吴伯半年前因腹主动脉瘤在鬼门关走了一遭,至今心有余悸。

拓展阅读

【综述】颈内动脉颅外段动脉瘤诊治的研究进展

该文简要综述了EICA的病因、临床表现、诊断和治疗方式以及值得关注的新技术、新进展。

European Radiology:究竟哪些因素能够影响颅内梭状动脉瘤的发展?

研究显示,动脉瘤壁的脂质浸润和积聚会促进动脉瘤壁的炎症,是动脉瘤发生、生长和破裂的关键因素,在HR-MRI中可以表现为动脉瘤壁增强(AWE)。

Science Bulletin |北京天坛:中国大型队列中颅内动脉瘤不稳定性的标志物和风险分层模型

这项研究揭示了UIA不稳定性的标志物,并提供了一个风险分层模型,可为UIA的治疗决策提供指导。

晚期转诊的动脉瘤修复术后肺动脉高压危象的结果和发生情况

在这项研究中,我们回顾了13年98个病例的经验,试图找到术后PHC发生的风险因素,并描述一个大型单一机构中TA修复后患者的结果。

Hypertension:RAAS抑制剂可显著降低高血压患者脑动脉瘤的破裂风险

RAAS抑制剂可显著降低高血压患者脑动脉瘤的破裂风险

2023 SICVE/SIRM指南:内脏和肾动脉动脉瘤的诊断、治疗和管理

意大利血管和血管内外科学会(SICVE,Italian Society of Vascular and Endovascular Surgery) · 2023-11-30

2022 NICE指南:动脉瘤破裂引起的蛛网膜下腔出血的诊断和管理(NG.228)

英国国家卫生与临床优化研究所(NICE,National Institute for Health and Clinical Excellence) · 2022-11-23

2016 AHA科学声明:血管移植物感染,真性动脉瘤以及血管内感染

美国心脏协会(AHA,American Heart Association) · 2016-10-13

2015重症动脉瘤性蛛网膜下腔出血管理专家共识

中国医师协会神经外科医师分会 · 2016-04-27