Hypertension:压力感受器所在动脉的粥样硬化程度独立预测缺血性卒中患者的血压下降

2020-05-04 MedSci原创 MedSci原创

BRA较高的总动脉粥样硬化负担与IS患者收缩压和舒张压的下降更平缓独立相关。BRA的总动脉粥样硬化负担对于预测和治疗IS患者的BP下降可能很重要。

夜间血压(BP)通常要下降白天水平的10%至20%,并且异常BP下降可能会独立于BP水平而影响血管健康。BP下降的调节有动脉压力感受性反射参与,其感受器主要位于颈动脉窦和主动脉弓。在缺血性卒中(IS)患者中,这些压力感受器所在的动脉(BRAs)频繁发生动脉粥样硬化,并且可能损害其BP调节能力。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在评估IS患者BRA动脉粥样硬化与BP下降之间的关联。

研究人员在IS发病第六天通过24小时动态血压监测来测量受试者BP下降发生率,并通过计算机扫描血管造影,对10个颈动脉窦和主动脉弓节段的动脉粥样硬化状况进行评分,并将其汇总为BRA的总动脉粥样硬化负担。

在245例IS患者中,有78.0%的患者BRA有动脉粥样硬化。BRA的总AS负担与收缩压下降率(r=-0.331; P<0.001)和舒张压下降率(r=-0.225; P<0.001)呈负相关。在调整了年龄、性别、血管危险因素、24小时BP平均值、颈动脉和颅内动脉粥样硬化评分之后,仍存在负相关关系(分别有调整后的β为-0.259 [95%CI为-0.416至-0.102];调整后的β为-0.178 [95%CI为-0.346至-0.010])。

总之,BRA较高的总动脉粥样硬化负担与IS患者收缩压和舒张压的下降更平缓独立相关。BRA的总动脉粥样硬化负担对于预测和治疗IS患者的BP下降可能很重要。

原始出处:

Qi Kong.et al.Total Atherosclerosis Burden of Baroreceptor-Resident Arteries Independently Predicts Blood Pressure Dipping in Patients With Ischemic Stroke.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.15036

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  5. 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  6. 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  7. 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createdTime=Wed May 06 06:07:46 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026633, encodeId=53fb10266332f, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon May 04 18:07:46 CST 2020, time=2020-05-04, status=1, ipAttribution=)]
    2021-01-05 feather89
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    2020-05-04 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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