ADvance研究发现深部脑刺激(DBS)可能治疗阿尔茨海默病

2012-12-13 MedSci news-medical

       入组功能性神经调节ADvance研究登记的首例阿尔茨海默病(AD)患者其深部脑刺激(DBS)系统置入成功。Advance研究将对患者穹窿部(是轻度阿尔茨海默病患者大脑记忆回路的主要流入和输出途径)进行DBS(DBS-f)治疗,以评估其治疗的安全性和潜在的临床获益。        ADvance研究进展迅

       入组功能性神经调节ADvance研究登记的首例阿尔茨海默病(AD)患者其深部脑刺激(DBS)系统置入成功。Advance研究将对患者穹窿部(是轻度阿尔茨海默病患者大脑记忆回路的主要流入和输出途径)进行DBS(DBS-f)治疗,以评估其治疗的安全性和潜在的临床获益。
       ADvance研究进展迅速,迄今为止,共进行了6次置入。美国第一例置入是在约翰霍普金斯大学,在多伦多西区医院又有5例患者进行置入。美国宾夕法尼亚大学已经加入了这项研究,参与ADvance研究的北美研究中心达到5家。
       功能性神经调节研究的总裁兼首席运营官,Todd Langevin说,“在短短两年内,我们已与专业临床人员合作并组建了一支有着丰富经验专业人才的精英团队,从资金,调节需求,研究启动以及大量的患者登记入选方面推进了公司的发展。”
       宾夕法尼亚记忆中心神经学副教授以及副主任David Wolk博士评论说,“考虑到迫切需要进展,以及阿尔茨海默病药物研究中不断出现的挑战,我们都对评估一种全新的能带来希望的方法感到兴奋。临床前试验表明,DBS可能会导致生理学改变从而可能改变疾病进展。ADvance将有助于我们确定刺激穹窿部是否会激活记忆回路从而改善记忆,并出现更佳的临床预后。”
有关ADvance

       ADvance是一项随机双盲对照试验,入组了年龄在55-80岁之间的20例轻度阿尔茨海默病患者。目前正在亚利桑那州凤凰城的Banner阿尔茨海默病研究所,美国约翰霍普金斯Bayview医学中心,多伦多西区医院,佛罗里达大学运动障碍和神经恢复中心,宾夕法尼亚大学招募患者参与研究。
       该试验将对开启DBS的作用与关闭DBS的作用进行比较。在12个月的时间内,患者将接受定期的生理学,心理学和认知评估。在此期间,在多个时间点对脑成像检测的糖代谢改变,以及与记忆有关的重要结构的大小进行评估。
有关DBS
       深部脑刺激(DBS)使用了一种手术植入医疗设备,类似于心脏起搏器,可提供精确定位大脑区域的轻度电子脉冲。Medtronic公司与世界各地的该领域领先的医生合作,提倡DBS治疗(1995年首次在欧洲,1997年在美国获得批准)。该疗法目前在加拿大获得授权,并在其他地区,包括欧盟和美国获批用于治疗特发性震颤的致残性症状,晚期帕金森病和慢性顽固性肌张力障碍。在欧洲和加拿大,DBS疗法已被批准用于难治性癫痫的治疗。在欧盟和美国HDE2,该疗法也被批准用于治疗严重性难治性强迫症。全球有超过10万人接受DBS治疗。

编译自:Advance Study to evaluate safety and benefit of DBS-f for patients with mild Alzheimer's.news-medical.2012-12-07.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1817580, encodeId=b803181e58077, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Aug 24 15:00:00 CST 2013, time=2013-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752981, encodeId=1ac01e52981c7, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Fri Dec 21 09:00:00 CST 2012, time=2012-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816557, encodeId=e154181655ed7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Tue Mar 26 10:00:00 CST 2013, time=2013-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457648, encodeId=f02e145e648f6, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd4c5968615, createdName=amyloid, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469934, encodeId=ad8e14699344b, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489906, encodeId=01ae14899064f, content=<a href='/topic/show?id=066b5e354a' target=_blank style='color:#2F92EE;'>#DBS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5735, encryptionId=066b5e354a, topicName=DBS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20778641139, createdName=linlin2315, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1817580, encodeId=b803181e58077, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Aug 24 15:00:00 CST 2013, time=2013-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752981, encodeId=1ac01e52981c7, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Fri Dec 21 09:00:00 CST 2012, time=2012-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816557, encodeId=e154181655ed7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Tue Mar 26 10:00:00 CST 2013, time=2013-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457648, encodeId=f02e145e648f6, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd4c5968615, createdName=amyloid, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469934, encodeId=ad8e14699344b, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489906, encodeId=01ae14899064f, content=<a href='/topic/show?id=066b5e354a' target=_blank style='color:#2F92EE;'>#DBS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5735, encryptionId=066b5e354a, topicName=DBS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20778641139, createdName=linlin2315, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1817580, encodeId=b803181e58077, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Aug 24 15:00:00 CST 2013, time=2013-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752981, encodeId=1ac01e52981c7, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Fri Dec 21 09:00:00 CST 2012, time=2012-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816557, encodeId=e154181655ed7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Tue Mar 26 10:00:00 CST 2013, time=2013-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457648, encodeId=f02e145e648f6, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd4c5968615, createdName=amyloid, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469934, encodeId=ad8e14699344b, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489906, encodeId=01ae14899064f, content=<a href='/topic/show?id=066b5e354a' target=_blank style='color:#2F92EE;'>#DBS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5735, encryptionId=066b5e354a, topicName=DBS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20778641139, createdName=linlin2315, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1817580, encodeId=b803181e58077, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Aug 24 15:00:00 CST 2013, time=2013-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752981, encodeId=1ac01e52981c7, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Fri Dec 21 09:00:00 CST 2012, time=2012-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816557, encodeId=e154181655ed7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Tue Mar 26 10:00:00 CST 2013, time=2013-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457648, encodeId=f02e145e648f6, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd4c5968615, createdName=amyloid, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469934, encodeId=ad8e14699344b, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489906, encodeId=01ae14899064f, content=<a href='/topic/show?id=066b5e354a' target=_blank style='color:#2F92EE;'>#DBS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5735, encryptionId=066b5e354a, topicName=DBS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20778641139, createdName=linlin2315, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=)]
    2012-12-14 amyloid
  5. [GetPortalCommentsPageByObjectIdResponse(id=1817580, encodeId=b803181e58077, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Aug 24 15:00:00 CST 2013, time=2013-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752981, encodeId=1ac01e52981c7, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Fri Dec 21 09:00:00 CST 2012, time=2012-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816557, encodeId=e154181655ed7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Tue Mar 26 10:00:00 CST 2013, time=2013-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457648, encodeId=f02e145e648f6, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd4c5968615, createdName=amyloid, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469934, encodeId=ad8e14699344b, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489906, encodeId=01ae14899064f, content=<a href='/topic/show?id=066b5e354a' target=_blank style='color:#2F92EE;'>#DBS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5735, encryptionId=066b5e354a, topicName=DBS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20778641139, createdName=linlin2315, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1817580, encodeId=b803181e58077, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Aug 24 15:00:00 CST 2013, time=2013-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752981, encodeId=1ac01e52981c7, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Fri Dec 21 09:00:00 CST 2012, time=2012-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816557, encodeId=e154181655ed7, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Tue Mar 26 10:00:00 CST 2013, time=2013-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457648, encodeId=f02e145e648f6, content=<a href='/topic/show?id=f9f684e27d6' target=_blank style='color:#2F92EE;'>#脑刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84727, encryptionId=f9f684e27d6, topicName=脑刺激)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd4c5968615, createdName=amyloid, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469934, encodeId=ad8e14699344b, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489906, encodeId=01ae14899064f, content=<a href='/topic/show?id=066b5e354a' target=_blank style='color:#2F92EE;'>#DBS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5735, encryptionId=066b5e354a, topicName=DBS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20778641139, createdName=linlin2315, createdTime=Fri Dec 14 15:00:00 CST 2012, time=2012-12-14, status=1, ipAttribution=)]
    2012-12-14 linlin2315

相关资讯

应对阿尔茨海默病:关怀比药物更重要

  “阿尔茨海默病患者面对的最大困难是缺少患者家属和护理人员的支持。真正能让老年人生活质量得到提高的,并不是药物,而是家属和护理人员的照顾。”在近日于京召开的阿尔茨海默病国际高级论坛上,中国科技大学生命科学院神经生物学教授周江宁对记者表示。   他介绍说,国外曾作过一个调查,对同一类型的病人进行五年药物治疗和非药物治疗,发现效果一样。非药物治疗可以有效延缓病情,方式包括锻炼、光照等。   “但

Diabetes Care:胰岛素抵抗或致老年痴呆灰质萎缩和认知障碍

  来自美国威斯康辛大学的一项前瞻性研究表明,晚期中年人群的胰岛素抵抗与早期阿尔茨海默病导致的进行性灰质萎缩显著相关。胰岛素抵抗也可能通过负性影响内侧颞叶的灰质体积,而影响患者编码片段信息的能力。研究在2012年10月15日在线发表于《糖尿病护理》(Diabetes Care)杂志。   胰岛素抵抗可导致受阿尔茨海默病影响大脑区域的葡萄糖摄取和其他功能失调。因此,胰岛素抵抗可能在阿尔茨

Neurobiol Aging:降压药哌唑嗪或有助治疗阿尔茨海默病

      英国的一项新研究显示,一种常用降血压药哌唑嗪可能有助于治疗阿尔茨海默病。患有该病的实验鼠服用这种降压药后,其记忆力减退的症状明显得到缓解。   英国帝国理工学院等机构的研究人员在新一期学术刊物《老年神经生物学》上报告说,去甲肾上腺素在记忆等方面具有重要作用,它的作用被扰乱是阿尔茨海默病的表现之一。研究人员因此在大量药物中筛选能调节去甲肾上腺素的物质,结果发现常用

阿尔茨海默病病理:男女有别

       第98届北美放射学会年会上的一项研究称,男性和女性阿尔茨海默病患者的灰质损害的类型各有不同。女性认知功能减退发生更早,而男性认知功能下降更快。        查尔斯顿南卡罗来纳州大学医学院的Maria Vittoria Spampinato博士说,女性发生脑萎缩早于男性,但她们的认知能力下降的没那么

Brian Research:GLP-1对老年痴呆症治疗有效

  阿尔斯特大学的科学家们研究发现一种治疗糖尿病的药物有潜力能够治疗神经退行性病变,如阿尔茨海默病。   II型糖尿病是阿尔茨海默病一个已知的危险因素,它破坏大脑内的胰岛素信号传导,这样会损害神经细胞并导致疾病。科学家们相信治疗II型糖尿病的药物同样能够使脑细胞的健康获益。为了证实这一点,科尔雷恩校区生物医学科学研究所的Christian H lscher教授和他的团队使用了一个名为 (Val8

Neurology:激素治疗降AD风险或取决于应用时机

  美国一项研究表明,激素治疗(HT)与阿尔茨海默病(AD)风险的相关性可能取决于应用时机。论文发表于《神经病学》[Neurology 2012,79(18):1846]杂志。   研究纳入1995~2006年间能提供确切绝经信息和HT应用情况的女性1768名。在随访期间共176例女性发生AD。利用考克斯(Cox)比例风险模型评估HT应用与AD的相关性。   结果为,在绝经5年内,应