Int Arch Allergy Immunol:过敏性鼻炎中牛磺酸的体内外抗过敏作用

2020-06-06 AlexYang MedSci原创

目前过敏性鼻炎(AR)的治疗并不完善。最近,有研究人员调查了牛磺酸对AR的治疗作用,并鉴定了潜在的机制。

目前过敏性鼻炎(AR)的治疗并不完善。最近,有研究人员调查了牛磺酸对AR的治疗作用,并鉴定了潜在的机制。

临床上,研究人员发现AR患者中血清中SOD3水平减少。牛磺酸治疗在HMC-1细胞中能够导致SOD3的蛋白和mRNA以剂量依赖的方式增加。SOD3的产生受过氧化物酶体增殖物激活受体-γ(PPAR-γ)调控,并对牛磺酸有响应。SOD3的过表达能够抑制促炎性细胞活素的释放,包括了肿瘤凋亡因子-α、白介素(IL)-4和IL-6。同时,还能够改善干扰素-γ的损失。SOD3和PPAR-γ能够通过调控细胞外信号调节激酶1/2(ERK1/2)的磷酸化影响炎症细胞因素的产生。OVA诱导的AR动物模型表明了牛磺酸在减轻过敏性炎症反应方面是有效的,能够减少AR小鼠的过敏性症状行为和减少嗜酸性细胞和肥大细胞浸润鼻腔。另外,牛磺酸治疗还能够增加SOD3和PPAR-γ的产生,从而通过磷酸化ERK1/2抑制促炎性细胞因子的表达。

最后,研究人员指出,牛磺酸能够作为过敏性障碍治疗的一种可能药物。

原始出处:

Jing Zhou , Yi Lu , Fengqian Li et al. In Vitro and in Vivo Antiallergic Effects of Taurine on Allergic Rhinitis. Int Arch Allergy Immunol. 15 May 2020.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2047263, encodeId=a9b1204e26365, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Nov 19 10:14:35 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049584, encodeId=0c0d204958414, content=<a href='/topic/show?id=264555e961a' target=_blank style='color:#2F92EE;'>#抗过敏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55796, encryptionId=264555e961a, topicName=抗过敏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7b6284, createdName=FukaiBao, createdTime=Sun Oct 04 22:14:35 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329377, encodeId=8d8213293e724, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Jun 08 09:14:35 CST 2020, time=2020-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486606, encodeId=c3e9148660615, content=<a href='/topic/show?id=28376e774e0' target=_blank style='color:#2F92EE;'>#牛磺酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67774, encryptionId=28376e774e0, topicName=牛磺酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27f8182618, createdName=gj0734, createdTime=Mon Jun 08 09:14:35 CST 2020, time=2020-06-08, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2047263, encodeId=a9b1204e26365, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Nov 19 10:14:35 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049584, encodeId=0c0d204958414, content=<a href='/topic/show?id=264555e961a' target=_blank style='color:#2F92EE;'>#抗过敏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55796, encryptionId=264555e961a, topicName=抗过敏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7b6284, createdName=FukaiBao, createdTime=Sun Oct 04 22:14:35 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329377, encodeId=8d8213293e724, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Jun 08 09:14:35 CST 2020, time=2020-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486606, encodeId=c3e9148660615, content=<a href='/topic/show?id=28376e774e0' target=_blank style='color:#2F92EE;'>#牛磺酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67774, encryptionId=28376e774e0, topicName=牛磺酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27f8182618, createdName=gj0734, createdTime=Mon Jun 08 09:14:35 CST 2020, time=2020-06-08, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2047263, encodeId=a9b1204e26365, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Nov 19 10:14:35 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049584, encodeId=0c0d204958414, content=<a href='/topic/show?id=264555e961a' target=_blank style='color:#2F92EE;'>#抗过敏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55796, encryptionId=264555e961a, topicName=抗过敏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7b6284, createdName=FukaiBao, createdTime=Sun Oct 04 22:14:35 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329377, encodeId=8d8213293e724, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Jun 08 09:14:35 CST 2020, time=2020-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486606, encodeId=c3e9148660615, content=<a href='/topic/show?id=28376e774e0' target=_blank style='color:#2F92EE;'>#牛磺酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67774, encryptionId=28376e774e0, topicName=牛磺酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27f8182618, createdName=gj0734, createdTime=Mon Jun 08 09:14:35 CST 2020, time=2020-06-08, status=1, ipAttribution=)]
    2020-06-08 膀胱癌
  4. [GetPortalCommentsPageByObjectIdResponse(id=2047263, encodeId=a9b1204e26365, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Nov 19 10:14:35 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049584, encodeId=0c0d204958414, content=<a href='/topic/show?id=264555e961a' target=_blank style='color:#2F92EE;'>#抗过敏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55796, encryptionId=264555e961a, topicName=抗过敏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7b6284, createdName=FukaiBao, createdTime=Sun Oct 04 22:14:35 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329377, encodeId=8d8213293e724, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Jun 08 09:14:35 CST 2020, time=2020-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486606, encodeId=c3e9148660615, content=<a href='/topic/show?id=28376e774e0' target=_blank style='color:#2F92EE;'>#牛磺酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67774, encryptionId=28376e774e0, topicName=牛磺酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27f8182618, createdName=gj0734, createdTime=Mon Jun 08 09:14:35 CST 2020, time=2020-06-08, status=1, ipAttribution=)]
    2020-06-08 gj0734

相关资讯

Eur Urol:恩杂鲁胺雄激素阻断治疗联用对转移激素敏感性前列腺癌患者健康相关生活质量影响研究

ARCHES研究中的转移激素敏感性前列腺癌(mHSPC)中,与单独的ADT治疗相比,恩杂鲁胺与雄激素阻断治疗(ADT)联用能够改善影像学无进展生存(rPFS)。最近,有研究人员评估了长达73周的患者报

盘点:过敏性鼻炎与治疗

【1】Front Pharmacol:大籽蒿花粉过敏性鼻炎1年皮下免疫治疗临床效果评估

“领跑者”上海质子重离子医院:5年治疗出院2692例患者

四年半前,64岁的张先生罹患高危局限期前列腺癌,来院治疗前,他曾因其它泌尿系统疾病做过大手术,不愿再次“大动干戈”的张先生选择在上海市质子重离子医院接受前列腺癌重离子治疗。随访

盘点:听力障碍与治疗

【1】Laryngoscope :辅助治疗偏头痛的药物在突发感官听力损失中的治疗

盘点:前列腺癌与治疗

【1】Nat Commun:前列腺特异性抗原动态能够预测个体对间歇性雄激素阻断治疗的个体响应

Otolaryngol Head Neck Surg:布地奈德与盐水洗鼻在过敏性鼻炎治疗中的比较

布地奈德鼻洗目前广泛的应用于慢性鼻窦炎的治疗,尤其是在内镜鼻窦手术后用于改善对炎症的控制,而其在过敏性鼻炎中的治疗还未有研究。最近,有研究人员评估了过敏性鼻炎(AR)患者对布地奈德缓冲高渗盐水鼻腔冲洗