Crit Care:重症监护病房老年人虚弱、谵妄与住院死亡率

2020-10-19 MedSci原创 MedSci原创

由此可见,虚弱和谵妄显著增加ICU患者住院死亡的风险。因此,识别虚弱患者尤为重要,有必要采取措施减少ICU内发生谵妄等不良事件的风险。

在接受重症监护的老年人中,虚弱被认为是病人预后的一个重要决定因素。在这类患者中,急性谵妄发作也很常见,但它和虚弱与死亡风险增加的关系尚未明确。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,这项研究旨在探讨重症监护老年人的临床虚弱、谵妄与医院死亡率之间的关系。

这项研究是重症监护谵妄研究的一部分,在最初的6个月基线期间,研究人员分析了50岁或50岁以上成年人入住重症监护时临床虚弱状态、急性谵妄发作、重症监护结局和住院治疗时间。

在6个月的基线期间,997名年龄在50岁或50岁以上的患者被纳入这项研究。受试者平均年龄为71岁(IQR为63-79);其中55%为男性(n=537)。在这些患者中,39.2% (95%CI为36.1-42.3%,n=396)患者的临床虚弱评分(CFS)为5分或5分以上,13.0% (n=127)患者至少有一次急性谵妄发作。虚弱患者谵妄发作的风险更高(17% vs. 10%,调整比值比(adjRR)=1.71,95%可信区间(CI)为1.20-2.43, p=0.003),住院时间更长(2.6天,95%可信区间为1-7天,p=0.009),住院死亡率风险更高(19% vs. 7%,adjRR=2.54,95%CI为1.72-3.75, p<0.001),相比无虚弱的患者。ICU中虚弱并经历谵妄急性发作的患者的院内死亡率为35%,而在ICU中同样经历谵妄的无虚弱患者的住院死亡率为10%。

由此可见,虚弱和谵妄显著增加ICU患者住院死亡的风险。因此,识别虚弱患者尤为重要,有必要采取措施减少ICU内发生谵妄等不良事件的风险。

原始出处:

David Sanchez.et al.Frailty, delirium and hospital mortality of older adults admitted to intensive care: the Delirium (Deli) in ICU study.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03318-2

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    2021-01-09 小马过河我

    非常厚

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    2020-10-21 bioon6
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    2020-10-19 1244c0ebm28暂无昵称

    学习学习

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    2020-10-19 布狸户

    ICU里面是蛮容易发生虚弱、谵妄

    0

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