Hypertension:冠状动脉钙化评分用于个性化降压治疗指导

2021-03-03 MedSci原创 MedSci原创

在当前指南不推荐治疗的人群中,利用CAC评分可指导高血压治疗和个体化降低心血管风险的预防策略。

2017年美国心脏病学会/美国心脏协会高血压指南推荐对动脉粥样硬化性血管疾病进行风险评估,以告知高血压或低危I期高血压成年患者的降压治疗。然而,使用冠状动脉钙(CAC)评分指导高血压治疗尚未有研究对其进行充分评估。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究中无心血管疾病的参与者来自多民族动脉粥样硬化研究、年轻成人冠状动脉风险发展研究和杰克逊心脏研究。

研究人员使用多变量调整的Cox回归根据CAC状态(CAC-0或CAC>0)和降压治疗评估了心血管事件(心力衰竭、卒中、冠心病)的发生风险。研究人员还估计了预防单个心血管事件所需的10年治疗人数。

这项研究纳入了6461名参与者(中位年龄为53岁;53.3%为女性;32.3%为黑人参与者)。在平均8.5年的随访中,共发生了347起心血管事件。与血压正常的人相比,血压升高/低风险的I期高血压且CAC>0(风险比为2.4 [95%CI为1.7-3.4])和高风险I/II期高血压(BP为140–160/80–100 mmHg)且CAC>0(风险比为2.9 [95%CI为2.1–4.0])的受试者发生心血管事件的风险更高。在不同种族的人群和单一研究结局中也存在类似的模式。在CAC-0的患者中,需要治疗的10年人数在血压升高/低危I期高血压患者中为160人,在高危I/II期高血压患者中为44人。在CAC>0的受试者中,需要治疗的10年人数分别为36和22人。

由此可见,在当前指南不推荐治疗的人群中,利用CAC评分可指导高血压治疗和个体化降低心血管风险的预防策略

原始出处:

Vibhu Parcha.et al.Coronary Artery Calcium Score for Personalization of Antihypertensive Therapy A Pooled Cohort Analysis.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16689

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    2021-11-23 feather89
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    2021-03-04 ms5000000518166734

    已读,受益匪浅

    0

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降压药物的种类多,但超过一半的患者服用单方药治疗无法使血压达标,往往需要服用至少两种以上的药物。多种药物联合的降压方案已经成为国际上治疗高血压的新趋势。ESC 2020会议上,一场关于复方制剂应用的讨

JAMA Network Open:对于收缩压低于130mmHg的成人,更佳舒张压范围是多少?

研究结果表明,舒张压低于60mmHg可能是有害的,而舒张压在70至80mmHg之间是收缩压低于130mmHg的患者的最佳目标。

Ann Intern Med :研究反转“降压治疗增加体位性低血压风险”,强化降压策略放心用!

一项荟萃分析表明,强化降压策略并没有增加血压急剧下降的风险,不应因先前存在的体位性低血压而避免。研究人员还发现,抗高血压药物治疗可以降低体位性低血压的风险,尤其是在没有糖尿病的患者中。

Circulation:40年,人群高血压控制可提高多少?

美国在上世纪60-70年代就开始了高血压意识、治疗和控制项目。虽然实施相应干预措施后,群众的血压(BP)控制和高血压相关疾病风险降低均有所改善,但目前尚不清楚这些BP变化是否可适用于不同的高危人群。