NEJM:Omadacycline治疗社区获得性细菌性肺炎

2019-02-12 zhangfna MedSci原创

研究认为Omadacycline治疗社区获得性细菌性肺炎的效果与莫西沙星相当

《新英格兰医学杂志》(NEJM)发表了NUZYRA™ (Omadacycline)III期临床试验OPTIC 和 OASIS-1的具体数据。Omadacycline,是一种新型氨基甲基环四环素,可以静脉注射或口服每日一次,给药后可在肺部聚集。近日研究人员考察了Omadacycline治疗社区获得性细菌性肺炎的疗效。

成年社区获得性细菌性肺炎患者(肺炎严重程度指数风险等级II、III或IV)随机接受Omadacycline(每12小时2次,每次100mg,随后调整为每24小时100mg)或莫西沙星(每24小时400mg),在治疗3天后,患者继续接受口服Omadacycline (每24小时300 mg)或莫西沙星(每24小时400 mg)治疗,总疗程为7-14天。研究的主要终点为早期临床响应,定义为咳嗽、排痰、胸膜性胸痛、呼吸困难症状至少改善2种,且72小时症状无恶化,未接受抢救抗菌药物治疗。次要终点为治疗后5-10天临床反应评估,定义为症状或体征的缓解或改善,无需进一步的抗菌治疗。

386人接受Omadacycline治疗,388人接受莫西沙星。早期临床反应(Omadacycline vs莫西沙星,81.1% vs 82.7%)和5-10天临床反应(Omadacycline vs莫西沙星,87.6% vs 85.1%)方面,组间差异不显著。Omadacycline治疗组41.1%的患者报告了不良事件,莫西沙星组为48.5%,其中最常见的不良事件包括肠道事件。12名患者死亡,其中Omadacycline组8人。

研究认为Omadacycline治疗社区获得性细菌性肺炎的效果与莫西沙星相当。

有关Omadacycline相关研究

原始出处:

Roman Stets et al. Omadacycline for Community-Acquired Bacterial Pneumonia.N Engl J Med, February 7, 2019.

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    2019-03-13 wxl882001

    了解一下

    0

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    2019-02-14 般若傻瓜
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    2019-02-12 wxl882001

    了解一下

    0

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    2019-02-12 飛歌

    学习了很有用不错

    0

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