Ann Intern Med:频繁饮酒会增加房颤发作风险

2021-10-06 Nebula MedSci原创

频繁饮酒会增加房颤发作风险

心房颤动(AF)是临床实践中最常见的心率失常。虽然相关研究的重点多是这种疾病的危险因素和治疗方法。患者的自我报告表明,急性饮酒可能引发独立性房颤事件

这是一项前瞻性、病例交叉的分析,旨在明确饮酒是否会增加房颤发作的风险。

招募了阵发性房颤患者,予以配备了持续的心电图(ECG)监测仪和踝部佩戴的经皮乙醇传感器,为期4周。使用心电记录仪上的一个按钮自行记录饮用的每一种酒精饮料的实时记录。采集手指血监测卵磷脂乙醇 (PEth) 以确证饮酒事件。

房颤发作前不同次数的饮酒事件的几率

共100位受试者(平均 64岁;79%的男性,85%的白种人),其中56位至少发生了一次房颤。PEth检测的结果与实时记录的饮酒量和经皮酒精传感器检测到的事件相关房颤发作前4小时内饮酒1次的几率增加2倍(优势比[OR] 2.02, 95% CI 1.38-3.17),饮酒至少2次的几率增加3倍以上 (OR 3.58[CI, 1.63 to 7.89])。

房颤发作前不同次数的饮酒事件的几率

房颤的发作还与较高的血液酒精浓度峰值(血酒精浓度每增加0.1%的OR 1.38, 95% 1.04-1.83)和酒精暴露(酒精暴露每增加4.7%的OR 1.14, 1.06-1.22)曲线下的总面积相关。

总而言之,独立性的房颤发作与近期饮酒率高相关。该研究数据表明,房颤发作可能既不是随机的,也不是完全不可预测的,而是可识别的、常见的,而且可改变的饮酒行为与与单发的房颤事件相关。

原始出处:

Marcus Gregory M,Vittinghoff Eric,Whitman Isaac R et al. Acute Consumption of Alcohol and Discrete Atrial Fibrillation Events.[J] .Ann Intern Med, 2021, https://doi.org/10.7326/M21-0228

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