Obstetrics & Gynecology:COVID-19疫苗不会损害孕妇的胎盘

2021-05-13 MedSci原创 MedSci原创

COVID-19疫苗或许对孕妇是安全的!

新冠肺炎(COVID-19)仍在全球肆虐,据Worldometers世界实时统计数据显示,截至北京时间2021513701分,全球累计确诊新冠肺炎(COVID-19)病例超过16106万例,累计死亡病例超334.4万例。诸多证据显示,新冠病毒可导致全身性疾病,包括消化系统、心血管系统以及泌尿系统等等。然而,新冠病毒是否可以直接感染人胎盘尚存争议。

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近日,发表在 Obstetrics & Gynecology杂志的一项研究显示,怀孕期间接种COVID-19疫苗是安全的,不会对胎盘造成损伤。

在这项研究中,来自美国西北大学医学院的研究人员对在芝加哥的普伦蒂斯妇女医院84名孕妇接种疫苗和116名孕妇未接种疫苗进行胎盘收集,并对出生后的整个胎盘进行了病理学检查。

结果发现,接种疫苗的孕妇更容易阴道分娩。有75名孕妇首次接种时间为分娩前46±24天,接种疫苗后,妇女表现出强大的抗体反应。同时,未观察到孕妇表现出新冠特征性临床症状,也没有疫苗触发的母体胎儿免疫耐受性崩溃的迹象。

临床、免疫学和组织学研究结果.

与对照组孕妇相比,接种疫苗孕妇的胎盘检查显示,蜕膜血管病变、胎儿血管灌注不良、低级别慢性绒毛膜炎或慢性组织细胞间质炎的发生率没有增加,而对照组高级别慢性绒毛膜炎的发生率高于接种组。

接种疫苗后,妇女表现出强大的抗体反应.

研究人员表示,胎盘就像飞机上的黑匣子。如果怀孕有任何异常,通常会看到胎盘的变化。目前研究结果来看,孕期接种COVID-19疫苗似乎是安全的。

原始出处

Elisheva D. Shanes et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination in PregnancyObstetrics & Gynecology (2021). DOI: 10.1097/AOG.0000000000004457

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