JAHA:重症监护患者右心室肺动脉耦联与死亡率的关系

2021-03-29 MedSci原创 MedSci原创

较低的TASV/RVSP比值与心脏重症监护病房患者的短期和长期死亡率增加相关,这些结果提示了RV肺动脉耦连受损作为不良预后的决定因素的重要性。

右心室(RV)肺动脉耦联受损与慢性心脏病患者较高的死亡率相关,但很少有研究对重症患者进行评估。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,在这项研究中,研究人员试图评估心脏重症监护病房患者RV肺动脉耦联(由三尖瓣环形收缩峰值组织多普勒速度(TASV)/估算的RV收缩压(RVSP)之比来定义)与死亡率之间的相关性。

研究人员使用2007年至2018年期间心脏重症监护病房住院数据库,纳入了在住院1天内测得的TASV/RVSP比值的患者。研究人员使用多因素logistic回归分析住院死亡率,并使用多变量Cox比例风险分析法分析了患者1年死亡率。

研究人员纳入了4259名平均年龄为69±15岁的患者(女性占40.1%)。56%参与者入院诊断为急性冠状动脉综合征,52%为心力衰竭,24%为呼吸衰竭和12%为心源性休克。平均TASV/RVSP比值为0.31±0.14,7%的患者住院死亡。较高的TASV/RVSP比值与较低的住院死亡率(校正后的单位比值比为0.68;95%CI为0.58-0.79;P<0.001)和住院幸存者的1年死亡率降低(调整后的风险比为0.83;95%CI为0.77-0.90;P<0.001)相关。在TASV/RVSP比值五分位数每增加一个分位数,研究人员观察到受试者住院率和1年死亡率逐步降低。调整左心室收缩和舒张功能后,TASV/RVSP比值与死亡率之间的相关性仍然显著。

由此可见,较低的TASV/RVSP比值与心脏重症监护病房患者的短期和长期死亡率增加相关,这些结果提示了RV肺动脉耦连受损作为不良预后的决定因素的重要性。需要进一步的研究以明确优化RV肺动脉耦联的干预措施是否可以改善患者结局

原始出处:

Jacob C. Jentzer.et al.Right Ventricular Pulmonary Artery Coupling and Mortality in Cardiac Intensive Care Unit Patients.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019015

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    2021-08-27 miyaping

    不错

    0

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    2021-03-31 zhaohui6731
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    2021-03-31 bioon6
  6. [GetPortalCommentsPageByObjectIdResponse(id=2018158, encodeId=02a1201815871, content=<a href='/topic/show?id=d0ca9596415' target=_blank style='color:#2F92EE;'>#重症监护患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95964, encryptionId=d0ca9596415, topicName=重症监护患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Jul 02 16:13:06 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1012135, encodeId=40fc101213527, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d91476414, createdName=miyaping, createdTime=Fri Aug 27 18:56:12 CST 2021, time=2021-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268475, encodeId=a11312684e520, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Mar 31 04:13:06 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543782, encodeId=4ad21543e82ae, content=<a href='/topic/show?id=52d93862e06' target=_blank style='color:#2F92EE;'>#右心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38627, encryptionId=52d93862e06, topicName=右心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18d13610637, createdName=124988c7m99暂无昵称, createdTime=Wed Mar 31 04:13:06 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551198, encodeId=88f3155119893, content=<a href='/topic/show?id=e2c1e230796' target=_blank style='color:#2F92EE;'>#监护#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72307, encryptionId=e2c1e230796, topicName=监护)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=477814173963, createdName=bioon6, createdTime=Wed Mar 31 04:13:06 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952062, encodeId=1cdd95206259, content=有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b75b4745734, createdName=hanhan19890105, createdTime=Mon Mar 29 15:43:05 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952037, encodeId=d49995203eba, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=97bc5436473, createdName=ms5000000187481758, createdTime=Mon Mar 29 13:32:09 CST 2021, time=2021-03-29, status=1, ipAttribution=)]
    2021-03-29 hanhan19890105

    有意义

    0

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    2021-03-29 ms5000000187481758

    123

    0

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