Stroke:中重度持续性高血糖对脑出血患者预后的影响

2021-12-01 MedSci原创 MedSci原创

持续性高血糖,无论是中度还是重度,都会增加非糖尿病脑出血患者的死亡或残疾的风险。

既往有研究报道血糖水平与脑卒中患者预后有关系,但是血糖与脑出血患者预后之间的关系尚未明确。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在评估持续性高血糖对1000名在症状出现4.5小时内入组的脑出血患者结局的影响。

研究人员分别在基线、入组24小时、48小时和72小时测量了受试者的血清葡萄糖水平,并根据他们血糖水平为140-180mg/dL和≥180mg/dL来定义中度和重度高血糖。持续性高血糖是通过连续2次(间隔24小时)的血清葡萄糖水平来进行定义。

研究人员在90天时评估了整个队列和既往糖尿病患者中度和重度高血糖与受试者死亡或残疾(由改良的Rankin量表评分为4-6分来进行定义)之间的关系。

在多变量分析中,中度(比值比为1.8[95%CI为1.1-2.8])和重度(比值比为1.8[95%CI为1.2-2.7])高血糖均与较高的90天死亡或残疾相关,且调整了格拉斯哥昏迷量表评分、血肿体积、脑室内出血、高脂血症、吸烟和高血压(高血糖与既往糖尿病之间无相互作用,P=0.996)。在既往没有糖尿病的患者中,调整上述潜在混杂因素后,中度(比值比为1.8[95%CI为1.0-3.2])和重度(比值比为2.0[95%CI为1.1-3.7])高血糖均与90天死亡或残疾相关。在既往患有糖尿病的患者中,中度和重度高血糖与90天死亡或残疾无关。

由此可见,持续性高血糖,无论是中度还是重度,都会增加非糖尿病脑出血患者的死亡或残疾的风险。

原始出处:

Adnan I. Qureshi.et al.Effect of Moderate and Severe Persistent Hyperglycemia on Outcomes in Patients With Intracerebral Hemorrhage.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.034928

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    2021-12-02 hbwxf
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    2021-12-02 查查佳佳

    过300万的肾衰竭患者需要维持透析治

    0

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    2021-12-01 964610855

    很透彻

    0

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