NEJM:早期康复期血浆治疗可降低门诊新冠肺炎患者住院风险

2022-04-01 zhangfan MedSci原创

对于新冠肺炎门诊患者,特别是未接种疫苗人群,在症状出现后早期接受恢复期血浆治疗可降低Covid-19疾病进展住院风险

在美国,约8%的SARS-CoV-2感染患者因Covid-19住院。目前大多数针对Covid-19治疗方法的目的是降低住院患者的疾病进展或死亡风险,仅三种单克隆抗体可用于新冠肺炎门诊治疗,但这些药物需在感染后5-7天使用且价格昂贵。SARS-CoV-2恢复期血浆产品可从已康复的Covid-19献血者中获得。近日研究人员考察了SARS-CoV-2康复期血浆对预防Covid-19门诊患者疾病进展的效果。


本次多中心、双盲、随机、对照试验中,研究人员评估了SARS-CoV-2康复期血浆产品对新冠肺炎门诊患者的有效性和安全性。新冠肺炎阳性患者在症状出现后8天接受治疗。研究的主要终点为28天内Covid-19相关住院。
1225名患者参与研究,其中1181人接受了血浆输注。在接受对照血浆输注的589名患者中,37人因Covid-19住院,而输注Covid-19康复患者血浆的592名患者中,17人因Covid-19住院(6.3% vs 2.9%,绝对分析差异为3.4%,相对风险降低54%)。对患者疫苗接种情况进行分层后发现,54名住院患者中有53名未接种疫苗,1名部分接种了疫苗,不能推断接种疫苗对SARS-CoV-2血浆产品有效性的影响。总计发生了16起3-4级不良事件,其中康复期血浆组7例,对照组9例,但无因不良事件住院。

早期恢复期血浆可使轻症患者住院风险下降54%

研究认为,对于新冠肺炎门诊患者,特别是未接种疫苗人群,在症状出现后早期接受恢复期血浆治疗可降低Covid-19疾病进展住院风险。
原始出处:
David J. Sullivan et al.Early Outpatient Treatment for Covid-19 with Convalescent Plasma . N Engl J Med,March 30, 2022.

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    2022-04-02 ms2000000248610760

    好文章,谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1667242, encodeId=a823166e242c9, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Mon Mar 13 15:44:49 CST 2023, time=2023-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951389, encodeId=ac06195138917, content=<a href='/topic/show?id=912d4943838' target=_blank style='color:#2F92EE;'>#康复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49438, encryptionId=912d4943838, topicName=康复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Sun Feb 12 00:44:49 CST 2023, time=2023-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251752, encodeId=7eab1251e52b0, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Sun Apr 03 02:44:49 CST 2022, time=2022-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208183, encodeId=a8121208183ca, content=好文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4eeb6405799, createdName=ms2000000248610760, createdTime=Sat Apr 02 16:04:12 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208178, encodeId=5c1112081e813, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5oGwP8cM4MicibJd7KiakV9nw4fdrErbJSOylzkEzFic4ibbVA1eAwe4yk15iaXMibH7VaQmRalpriczicX9uF66oYsg2DA/132, createdBy=07105229708, createdName=Catcher, createdTime=Sat Apr 02 15:44:06 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208123, encodeId=b0b41208123f7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Apr 02 14:33:36 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1207823, encodeId=2bb0120e82369, content=学习学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57545476725, createdName=陈文志, createdTime=Fri Apr 01 12:58:12 CST 2022, time=2022-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1207820, encodeId=ca44120e820f7, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Fri Apr 01 12:47:37 CST 2022, time=2022-04-01, status=1, ipAttribution=)]
    2022-04-02 Catcher

    不错

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1667242, encodeId=a823166e242c9, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Mon Mar 13 15:44:49 CST 2023, time=2023-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951389, encodeId=ac06195138917, content=<a href='/topic/show?id=912d4943838' target=_blank style='color:#2F92EE;'>#康复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49438, encryptionId=912d4943838, topicName=康复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Sun Feb 12 00:44:49 CST 2023, time=2023-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251752, encodeId=7eab1251e52b0, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Sun Apr 03 02:44:49 CST 2022, time=2022-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208183, encodeId=a8121208183ca, content=好文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4eeb6405799, createdName=ms2000000248610760, createdTime=Sat Apr 02 16:04:12 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208178, encodeId=5c1112081e813, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5oGwP8cM4MicibJd7KiakV9nw4fdrErbJSOylzkEzFic4ibbVA1eAwe4yk15iaXMibH7VaQmRalpriczicX9uF66oYsg2DA/132, createdBy=07105229708, createdName=Catcher, createdTime=Sat Apr 02 15:44:06 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208123, encodeId=b0b41208123f7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Apr 02 14:33:36 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1207823, encodeId=2bb0120e82369, content=学习学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57545476725, createdName=陈文志, createdTime=Fri Apr 01 12:58:12 CST 2022, time=2022-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1207820, encodeId=ca44120e820f7, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Fri Apr 01 12:47:37 CST 2022, time=2022-04-01, status=1, ipAttribution=)]
    2022-04-02 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1667242, encodeId=a823166e242c9, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Mon Mar 13 15:44:49 CST 2023, time=2023-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951389, encodeId=ac06195138917, content=<a href='/topic/show?id=912d4943838' target=_blank style='color:#2F92EE;'>#康复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49438, encryptionId=912d4943838, topicName=康复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Sun Feb 12 00:44:49 CST 2023, time=2023-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251752, encodeId=7eab1251e52b0, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Sun Apr 03 02:44:49 CST 2022, time=2022-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208183, encodeId=a8121208183ca, content=好文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4eeb6405799, createdName=ms2000000248610760, createdTime=Sat Apr 02 16:04:12 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208178, encodeId=5c1112081e813, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5oGwP8cM4MicibJd7KiakV9nw4fdrErbJSOylzkEzFic4ibbVA1eAwe4yk15iaXMibH7VaQmRalpriczicX9uF66oYsg2DA/132, createdBy=07105229708, createdName=Catcher, createdTime=Sat Apr 02 15:44:06 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208123, encodeId=b0b41208123f7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Apr 02 14:33:36 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1207823, encodeId=2bb0120e82369, content=学习学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57545476725, createdName=陈文志, createdTime=Fri Apr 01 12:58:12 CST 2022, time=2022-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1207820, encodeId=ca44120e820f7, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Fri Apr 01 12:47:37 CST 2022, time=2022-04-01, status=1, ipAttribution=)]
    2022-04-01 陈文志

    学习学习。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1667242, encodeId=a823166e242c9, content=<a href='/topic/show?id=ea04891988c' target=_blank style='color:#2F92EE;'>#血浆治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89198, encryptionId=ea04891988c, topicName=血浆治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150026134820, createdName=jianjun75, createdTime=Mon Mar 13 15:44:49 CST 2023, time=2023-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951389, encodeId=ac06195138917, content=<a href='/topic/show?id=912d4943838' target=_blank style='color:#2F92EE;'>#康复期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49438, encryptionId=912d4943838, topicName=康复期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Sun Feb 12 00:44:49 CST 2023, time=2023-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251752, encodeId=7eab1251e52b0, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Sun Apr 03 02:44:49 CST 2022, time=2022-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208183, encodeId=a8121208183ca, content=好文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4eeb6405799, createdName=ms2000000248610760, createdTime=Sat Apr 02 16:04:12 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208178, encodeId=5c1112081e813, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5oGwP8cM4MicibJd7KiakV9nw4fdrErbJSOylzkEzFic4ibbVA1eAwe4yk15iaXMibH7VaQmRalpriczicX9uF66oYsg2DA/132, createdBy=07105229708, createdName=Catcher, createdTime=Sat Apr 02 15:44:06 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1208123, encodeId=b0b41208123f7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Apr 02 14:33:36 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1207823, encodeId=2bb0120e82369, content=学习学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57545476725, createdName=陈文志, createdTime=Fri Apr 01 12:58:12 CST 2022, time=2022-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1207820, encodeId=ca44120e820f7, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Fri Apr 01 12:47:37 CST 2022, time=2022-04-01, status=1, ipAttribution=)]
    2022-04-01 yangchou

    好文章,谢谢分享。

    0

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