Cell Metab :治疗脱发有望!谷氨酰胺代谢控制毛囊干细胞的可逆转化!

2020-10-21 王木木 生物探索

日常生活中,我们的皮肤和毛囊每天都会暴露在紫外线等环境之下,经历着损害、清除再更新生长的循环。每个人每天大约会流失5亿个细胞和100多根头发。

日常生活中,我们的皮肤和毛囊每天都会暴露在紫外线等环境之下,经历着损害、清除再更新生长的循环。每个人每天大约会流失5亿个细胞和100多根头发。毛囊是供毛发生长的鞘状结构,毛囊干细胞(HFSC)具有慢周期性、未分化性、体外增殖能力强等特点,其通过自我更新,分化和去分化来维持其自身动态平衡,参与表皮、毛囊等的分化和皮肤创伤愈合等过程。

当毛发开始生长时,HFSC被激活产生祖细胞,随后分化为外根鞘(ORS)细胞以提供细胞毛囊生长所需的营养,而当毛发生长处于退行期时,部分ORS前体细胞会去分化形成新的HFSC。该过程受多种细胞内外信号分子调控,但目前对其调控机制仍知之甚少。

近日,来自德国科隆大学和马克斯-普朗克衰老生物学研究所的研究人员在《Cell Metabolism》上发表了题为Glutamine Metabolism Controls Stem Cell FateReversibility and Long-Term Maintenance in the Hair Follicle的研究成果,发现毛发干细胞对头发的再生至关重要,它们可以通过响应组织中的低氧浓度而切换其代谢状态由谷氨酰胺代谢转变为糖酵解,增加ORS祖细胞向HFSCs转化,从而延长其寿命。

为了了解HFSC的调控机制,研究人员检测了HFSC及毛囊ORS祖细胞这两种细胞群体的转录组和代谢谱。发现ORS祖细胞中参与线粒体ATP合成和OXPHOS(线粒体中氧化磷酸化过程,产生大量能量和活性氧)的基因高度表达,TCA循环中的代谢产物也明显增加,而HFSC中的线粒体明显较少,且线粒体相关基因的表达水平也较低。此外,毛发生长初期的毛囊中,ORS区域的氧化程度比在生长阶段的毛囊中更高,与处于激活或分化状态的HFSCs一致。这表明ORS祖细胞状态与OXPHOS和TCA循环活性水平升高及氧化增加有关。

HFSCs和早期祖细胞具有不同的代谢特征

之后,研究人员测试了增加OXPHOS是否可以定向调控HFSC,发现低浓度O2增加会触发HFSCs的增加,2%的O2即可增强祖细胞返回HFSC状态。进一步研究低氧调控HFSC的机制,发现低氧会促进为细胞提供能量的谷氨酰胺代谢和细胞呼吸转变为以葡萄糖为碳源的糖酵解的升高,从而增加依赖于低氧糖酵解提供能量的HFSCs。而HFSCs向ORS祖细胞的发展需要由OXPHOS和谷氨酰胺代谢提供大量能量。

低氧促进HFSCs的增加

为了进一步确定调控HFSCs的机制,研究人员又对在两种细胞中差异表达的代谢基因的上游调控因子进行鉴定,发现mTORC2(mTOR信号转导调节细胞的生长,能量和氧气消耗等过程)的组成蛋白之一Rictor可能也参与调控HFSCs。并进一步通过构建Rictor敲除小鼠进行验证,可观察到缺少Rictor的小鼠的毛囊再生和循环明显延迟,HFSC含量降低,且该突变型小鼠随着年龄增大表现出HFSCs的耗尽和年龄诱导性脱发。对其机制进一步研究,发现mTORC2通过调控其下游靶基因Akt-pS473的激活状态,进而抑制谷氨酰胺酶 (GLS)的表达和线粒体谷氨酸代谢,降低谷氨酰胺代谢,从而调控ORS祖细胞返回为HFSCs。

HFSC的分化需要线粒体代谢和谷氨酰胺分解

mTORC2通过Akt控制HFSC代谢和分化可逆性

该研究的通讯作者Sabine A. Eming说:“我们还观察到谷氨酰胺酶抑制剂能够恢复Rictor缺陷型小鼠的毛囊干细胞功能,这证明了修饰代谢途径可能是增强组织再生能力的一种有效方法。未来的主要目标将是了解如何将这些研究结果转化应用于临床,使利用药物减弱毛囊老化,治疗脱发成为可能。”

原始出处:

Christine S Kim, Xiaolei Ding, Kira Allmeroth, et al.Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle.Cell Metab. 2020 Oct 6;32(4):629-642.e8. doi: 10.1016/j.cmet.2020.08.011.

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    2021-03-18 guojianrong
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    2021-06-30 维他命
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Thu Oct 22 00:43:25 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893607, encodeId=8bca89360e22, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200729/2ee0ca079ce64987b1195eb6aa20a1f4/ae923a98c9704879bacdc81d9fa7479a.jpg, createdBy=a3ab5398909, createdName=ms6000001113694287, createdTime=Wed Oct 21 22:19:23 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893599, encodeId=e558893599c2, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/ca8787cdc6654f4aaf585d0d0d512b58/44909b2362294ce28f84385675732298.jpg, createdBy=aecb2334654, createdName=swq-123, createdTime=Wed Oct 21 22:06:50 CST 2020, time=2020-10-21, status=1, ipAttribution=)]
  4. 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encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 16 00:47:58 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025519, encodeId=7407102551947, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sat Oct 24 12:47:58 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389132, encodeId=ba5d138913228, content=<a href='/topic/show?id=c130636834c' target=_blank style='color:#2F92EE;'>#毛囊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63683, encryptionId=c130636834c, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Thu Oct 22 00:43:25 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893607, encodeId=8bca89360e22, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200729/2ee0ca079ce64987b1195eb6aa20a1f4/ae923a98c9704879bacdc81d9fa7479a.jpg, createdBy=a3ab5398909, createdName=ms6000001113694287, createdTime=Wed Oct 21 22:19:23 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893599, encodeId=e558893599c2, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/ca8787cdc6654f4aaf585d0d0d512b58/44909b2362294ce28f84385675732298.jpg, createdBy=aecb2334654, createdName=swq-123, createdTime=Wed Oct 21 22:06:50 CST 2020, time=2020-10-21, status=1, ipAttribution=)]
    2020-11-16 一闲
  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/ca8787cdc6654f4aaf585d0d0d512b58/44909b2362294ce28f84385675732298.jpg, createdBy=aecb2334654, createdName=swq-123, createdTime=Wed Oct 21 22:06:50 CST 2020, time=2020-10-21, status=1, ipAttribution=)]
    2020-10-24 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

  6. 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encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 16 00:47:58 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025519, encodeId=7407102551947, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sat Oct 24 12:47:58 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389132, encodeId=ba5d138913228, content=<a href='/topic/show?id=c130636834c' target=_blank style='color:#2F92EE;'>#毛囊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63683, encryptionId=c130636834c, 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1888230, encodeId=35b41888230a4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Mar 18 07:47:58 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962327, encodeId=35e3196232eac, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, 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encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 16 00:47:58 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025519, encodeId=7407102551947, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sat Oct 24 12:47:58 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389132, encodeId=ba5d138913228, content=<a href='/topic/show?id=c130636834c' target=_blank style='color:#2F92EE;'>#毛囊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63683, encryptionId=c130636834c, topicName=毛囊)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Fri Oct 23 03:47:58 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441136, encodeId=24b914411367c, content=<a href='/topic/show?id=5d9963686b4' target=_blank style='color:#2F92EE;'>#毛囊干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63686, encryptionId=5d9963686b4, topicName=毛囊干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcbd4793927, createdName=ms7474195563676018, createdTime=Fri Oct 23 03:47:58 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893641, encodeId=362689364109, content=真的吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Thu Oct 22 00:43:25 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893607, encodeId=8bca89360e22, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200729/2ee0ca079ce64987b1195eb6aa20a1f4/ae923a98c9704879bacdc81d9fa7479a.jpg, createdBy=a3ab5398909, createdName=ms6000001113694287, createdTime=Wed Oct 21 22:19:23 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893599, encodeId=e558893599c2, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/ca8787cdc6654f4aaf585d0d0d512b58/44909b2362294ce28f84385675732298.jpg, createdBy=aecb2334654, createdName=swq-123, createdTime=Wed Oct 21 22:06:50 CST 2020, time=2020-10-21, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1888230, encodeId=35b41888230a4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Mar 18 07:47:58 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962327, encodeId=35e3196232eac, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Jun 30 04:47:58 CST 2021, time=2021-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872025, encodeId=d14618e2025d5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jul 15 01:47:58 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896764, encodeId=50ff1896e6497, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 16 00:47:58 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025519, encodeId=7407102551947, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sat Oct 24 12:47:58 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389132, encodeId=ba5d138913228, content=<a href='/topic/show?id=c130636834c' target=_blank style='color:#2F92EE;'>#毛囊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63683, encryptionId=c130636834c, topicName=毛囊)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Fri Oct 23 03:47:58 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441136, encodeId=24b914411367c, content=<a href='/topic/show?id=5d9963686b4' target=_blank style='color:#2F92EE;'>#毛囊干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63686, encryptionId=5d9963686b4, topicName=毛囊干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcbd4793927, createdName=ms7474195563676018, createdTime=Fri Oct 23 03:47:58 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893641, encodeId=362689364109, content=真的吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Thu Oct 22 00:43:25 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893607, encodeId=8bca89360e22, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200729/2ee0ca079ce64987b1195eb6aa20a1f4/ae923a98c9704879bacdc81d9fa7479a.jpg, createdBy=a3ab5398909, createdName=ms6000001113694287, createdTime=Wed Oct 21 22:19:23 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893599, encodeId=e558893599c2, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/ca8787cdc6654f4aaf585d0d0d512b58/44909b2362294ce28f84385675732298.jpg, createdBy=aecb2334654, createdName=swq-123, createdTime=Wed Oct 21 22:06:50 CST 2020, time=2020-10-21, status=1, ipAttribution=)]
    2020-10-22 liyu7822

    真的吗

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1888230, encodeId=35b41888230a4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Mar 18 07:47:58 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962327, encodeId=35e3196232eac, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, 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encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 16 00:47:58 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025519, encodeId=7407102551947, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sat Oct 24 12:47:58 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389132, encodeId=ba5d138913228, content=<a href='/topic/show?id=c130636834c' target=_blank style='color:#2F92EE;'>#毛囊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63683, encryptionId=c130636834c, topicName=毛囊)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Fri Oct 23 03:47:58 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441136, encodeId=24b914411367c, content=<a href='/topic/show?id=5d9963686b4' target=_blank style='color:#2F92EE;'>#毛囊干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63686, encryptionId=5d9963686b4, topicName=毛囊干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcbd4793927, createdName=ms7474195563676018, createdTime=Fri Oct 23 03:47:58 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893641, encodeId=362689364109, content=真的吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Thu Oct 22 00:43:25 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893607, encodeId=8bca89360e22, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200729/2ee0ca079ce64987b1195eb6aa20a1f4/ae923a98c9704879bacdc81d9fa7479a.jpg, createdBy=a3ab5398909, createdName=ms6000001113694287, createdTime=Wed Oct 21 22:19:23 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893599, encodeId=e558893599c2, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/ca8787cdc6654f4aaf585d0d0d512b58/44909b2362294ce28f84385675732298.jpg, createdBy=aecb2334654, createdName=swq-123, createdTime=Wed Oct 21 22:06:50 CST 2020, time=2020-10-21, status=1, ipAttribution=)]
    2020-10-21 ms6000001113694287

    学习了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1888230, encodeId=35b41888230a4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Thu Mar 18 07:47:58 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962327, encodeId=35e3196232eac, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, 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encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 16 00:47:58 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025519, encodeId=7407102551947, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sat Oct 24 12:47:58 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389132, encodeId=ba5d138913228, content=<a href='/topic/show?id=c130636834c' target=_blank style='color:#2F92EE;'>#毛囊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63683, encryptionId=c130636834c, topicName=毛囊)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Fri Oct 23 03:47:58 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441136, encodeId=24b914411367c, content=<a href='/topic/show?id=5d9963686b4' target=_blank style='color:#2F92EE;'>#毛囊干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63686, encryptionId=5d9963686b4, topicName=毛囊干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcbd4793927, createdName=ms7474195563676018, createdTime=Fri Oct 23 03:47:58 CST 2020, time=2020-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893641, encodeId=362689364109, content=真的吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Thu Oct 22 00:43:25 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893607, encodeId=8bca89360e22, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200729/2ee0ca079ce64987b1195eb6aa20a1f4/ae923a98c9704879bacdc81d9fa7479a.jpg, createdBy=a3ab5398909, createdName=ms6000001113694287, createdTime=Wed Oct 21 22:19:23 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893599, encodeId=e558893599c2, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201021/ca8787cdc6654f4aaf585d0d0d512b58/44909b2362294ce28f84385675732298.jpg, createdBy=aecb2334654, createdName=swq-123, createdTime=Wed Oct 21 22:06:50 CST 2020, time=2020-10-21, status=1, ipAttribution=)]
    2020-10-21 swq-123

    很棒

    0

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对于当代青年人来说,最难受的莫过于年纪轻轻就“没”了头发。据统计,在中国,大约2.5亿人深受脱发困扰,平均六个人当中就有一个人存在脱发症状,并且脱发现象日趋低龄化。

Science新概念:淋巴系统在脱发和伤口愈合中起关键作用

我们的皮肤每天在承受着各种磨损,好在它具有非凡的自我修复能力。干细胞遍布在被称为“生态位”的支持性微环境中,严格控制着修复过程。过多的组织可能会导致癌症等问题,而太少的组织又可能会加速衰老。但直到现在,科学家们还不确定干细胞本身是否可以通过重塑其生态位来指导其他干细胞形成新的皮肤。

EMBO Mol Med:化疗脱发?靶向药CDK4/6抑制剂或将带来防脱发新突破

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Cell:揭秘鸡皮疙瘩与“防秃头”之间有着强大联系...

近日,发表在《Cell》上的一项研究中,来自美国哈佛大学的科学家们给了我们一些惊人的线索:引起鸡皮疙瘩的细胞类型对于调节再生毛囊和头发的干细胞也是非常重要的。简而言之,鸡皮疙瘩与“防秃头”之间有着联系

Cell Metabolism:还在为脱发烦恼?研究表明微调毛囊干细胞代谢,可治疗脱发

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婴儿脱发,原来是这些原因!

婴儿脱发是家长常常咨询的问题,但究竟是正常的生理现象、毛囊毛发疾病、抑或是多器官系统疾病的部分表现,下面让我们来了解一下婴儿脱发有哪些原因呢?