JACC:半乳凝素-3是心梗患者死亡和心衰的独立预测因子

2019-05-16 不详 MedSci原创

半乳凝素-3(Gal-3)与心脏纤维化呈相关性,但其与心梗后不良事件的相关性尚不清楚,本研究的目的旨在评估Gal-3在心梗中的预测价值。本研究共纳入了1342名心梗患者(平均年龄67.1岁,男性占61.3%,78.8%为非ST段抬高型心梗),Gal-3水平升高的患者往往更年长,且并发症更多。经过平均5.4年时间的随访,484名患者死亡,368名患者发展为心衰。经年龄、性别、并发症和肌钙蛋白等因素调

半乳凝素-3(Gal-3)与心脏纤维化呈相关性,但其与心梗后不良事件的相关性尚不清楚,本研究的目的旨在评估Gal-3在心梗中的预测价值。

本研究共纳入了1342名心梗患者(平均年龄67.1岁,男性占61.3%,78.8%为非ST段抬高型心梗),Gal-3水平升高的患者往往更年长,且并发症更多。经过平均5.4年时间的随访,484名患者死亡,368名患者发展为心衰。经年龄、性别、并发症和肌钙蛋白等因素调整后,与Gal-3水平位于后三分之一的患者相比,Gal-3水平高的患者死亡风险更高,心衰风险也更高(ptrend < 0.001)。另外,心衰风险的增高与心衰的类型不相关,与复发性心肌梗死的发生也无关。

研究结果显示,半乳凝素-3是心梗后患者死亡和心衰的独立预测因子。

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