CLIN CANCER RES:成纤维细胞亚型调节乳腺导管癌对雌激素的反应

2017-04-08 MedSci MedSci原创

抗内分泌治疗是雌激素受体阳性乳腺癌最有效的治疗方式,但是治疗耐受是临床上常见的并发症。乳腺癌相关成纤维细胞(CAF)是肿瘤微环境中最大的组成部分,在雌激素受体表达以及抗内分泌治疗耐受起到了一定作用。

抗内分泌治疗是雌激素受体阳性乳腺癌最有效的治疗方式,但是治疗耐受是临床上常见的并发症。乳腺癌相关成纤维细胞(CAF)是肿瘤微环境中最大的组成部分,在雌激素受体表达以及抗内分泌治疗耐受起到了一定作用。

CLIN CANCER RES近期报道了一篇文章,研究了乳腺癌中成纤维细胞亚型及其对治疗的影响。作者分析了雌激素受体阳性乳腺癌组织中CD146阳性(CD146pos)和CD146阴性(CD146neg)成纤维细胞。将雌激素受体阳性的肿瘤细胞与CD146阳性或CD146阴性的成纤维细胞共培养,评估肿瘤增殖情况以及他莫昔芬敏感性。使用RNA测序预测雌激素受体阳性乳腺癌患者接受他莫昔芬治疗的复发情况。研究结果发现通过CD146表达情况可以将雌激素受体阳性乳腺癌中的成纤维细胞分为两个亚型。CD146neg成纤维细胞抑制雌激素受体阳性乳腺癌细胞的雌激素受体表达,降低肿瘤细胞对雌激素的敏感度,增加肿瘤细胞对他莫昔芬治疗的抵抗性。与之相反,CD146pos成纤维细胞则维持雌激素受体阳性乳腺癌细胞雌激素受体表达,维持雌激素依赖的细胞增殖以及对他莫昔芬的敏感性。CD146pos成纤维细胞培养液可以恢复他莫昔芬耐药的乳腺癌细胞对他莫昔芬的敏感性。基因表达主要为为CD146neg成纤维的乳腺癌与他莫昔芬反应差以及不良患者结局有关。

文章最后得出结论,肿瘤相关成纤维细胞的不同亚型对激素受体阳性乳腺癌患者治疗反应及预后有影响,应考虑作为治疗靶点。

原始出处:
Heather M.Brechbuhl,Jessica Finlay-Schultz,et al.Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen.CLIN CANCER RES.April 2017 doi:10.1158/1078-0432.CCR-15-2851

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    2017-04-09 半夏微凉

    学习了谢谢分享

    0

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    2017-04-09 刘煜

    阅读了谢谢分享。

    0

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    2017-04-09 laymankey

    感谢分享一下!

    0

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