Mol Immunol:DZNep能够减轻过敏性气道炎症

2021-01-09 AlexYang MedSci原创

越来越多的证据表明,zeste同源体2(EZH2)增强剂在各种生理功能和癌症发病机制中发挥着作用。然而,其对过敏性疾病的作用仍然存在争议。最近,有研究人员调查了EZH2在过敏性气道炎症的发病机制中的作

越来越多的证据表明,zeste同源体2(EZH2)增强剂在各种生理功能和癌症发病机制中发挥着作用。然而,其对过敏性疾病的作用仍然存在争议。最近,有研究人员调查了EZH2在过敏性气道炎症的发病机制中的作用

研究人员在卵清蛋白(OVA)诱导的过敏性气道炎症小鼠模型中腹腔注射了 3-Deazaneplanocin A (DZNep)(一种EZH2的间接抑制剂)。通过免疫组织化学(IHC)和蛋白质印迹检测了EZH2在过敏性气道组织中的表达,还使用苏木精和伊红(H&E)染色和过碘酸-希夫(PAS)染色检测了小鼠鼻腔和肺部的炎症细胞浸润和小叶细胞增生。另外,还使用了酶联免疫吸附试验(ELISA)评估了支气管肺泡灌洗液(BALF)中细胞因子的水平,包括IL-4、IFN-γ、IL-6和IL-10。结果表明,DZNep处理抑制了EZH2的表达(P<0.05)。DZNep可显著抑制炎症细胞浸润(P< 0.0001)和小叶细胞增生(P< 0.001)。此外,它还能抑制BALF中IL-4(P< 0.0001)和IL-6(P< 0.01)的分泌。

DZNep减少了上呼吸道嗜酸细胞浸润

最后,研究人员指出,DZNep能够减轻过敏性气道炎症,可能作为过敏性鼻炎和哮喘的新治疗方案

原始出处:

Hang Li, Jian Li, Tong Lu et al. DZNep attenuates allergic airway inflammation in an ovalbumin-induced murine model. Mol Immunol. Dec 2020

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    2021-01-11 薄荷糖OOO

    #学习#学习了

    0

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    2021-01-09 jyzxjiangqin

    好文章!

    0

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