J Viral Hepat:慢性乙肝病毒感染患者的血清HBV-RNA自然史

2018-09-15 MedSci MedSci原创

在慢性乙肝病毒感染的自然过程中,HBV-RNA的基线水平和病毒复制中间产物的构成有显著差异。

研究背景:HBV-RNA病毒样颗粒代表了一种血清生物标记,用于评估临床实践中的病毒复制。然而,血清HBV-RNA的基线水平以及它们与病毒复制中间体和肝脏疾病的联系,目前仍知之甚少。

研究方法:本研究为一横断面研究,纳入102例患者。102例患者的疾病分别处于免疫耐受期(IT)、HBeAg阳性免疫活跃期(HBeAg+IA)、非活跃期(IC)、HBeAg阴性免疫活跃期(HBeAg-IA) 。定量检测患者血清HBV-RNA水平和66例配对患者的肝组织HBV生物标记物,分析其与生化ALT、组织病理学评分以及与其他病毒复制标记物间的关系。

研究结果:在疾病不同时期,血清HBV-RNA含量不同;在免疫耐受期,HBV-RNA的水平最高(6.78 ± 0.83 log10 copies mL(-1) ) ,随后为HBeAg+IA 期(5.73± 1.16 log10 copies mL(-1) ), HBeAg-IA期 (4.52±1.25 log10 copies mL(-1) ) 和IC 期(2.96±0.40 log10 copies mL(-1) ) 。当病例分层为各阶段,尽管与其他病毒复制的中间产物的相关性减弱或消失;但血清HBV-RNA与各时期的HBV-DNA水平相关。在不同阶段发现了不同病毒标记物组合,在IC患者中,HBsAg与血清HBV-RNA的比率最高;而血清HBV-RNA与肝内HBV-RNA的比率,以及肝内HBV-DNA与肝内HBV-RNA的比率,在IT患者中明显更高。

研究结论:在慢性乙肝病毒感染的自然过程中,HBV-RNA的基线水平和病毒复制中间产物的构成有显著差异。

原始出处

Wang J, Yu Y, Li G, et al. Natural history of serum HBV-RNA in chronic HBV infection HBV RNA chronic hepatitis B  natural history. J Viral Hepat, 2018, 25(9), 1038-1047.

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    2019-03-07 klivis
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    2018-09-17 gwc384
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    2018-09-16 kafei

    学习了谢谢

    0

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    2018-09-16 明月清辉

    谢谢分享,学习了

    0

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    2018-09-16 清风拂面

    谢谢分享学习

    0

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