Artif Cells Nanomed Biotechnol:缺氧MSC外泌体通过miRNA-210发挥更好的心梗后心功能保护作用

2017-12-14 Johnny “外泌体之家”微信号

浙江大学医学院附属第二医院余红教授的这项研究,目的是探究在心肌修复方面来自缺氧处理的MSC(Exo(H))的外泌体是否优于那些从常氧处理的MSC(Exo(N))。

缺氧处理增强间充质干细胞(MSC)的旁分泌效应。浙江大学医学院附属第二医院余红教授的这项研究,目的是探究在心肌修复方面来自缺氧处理的MSC(Exo(H))的外泌体是否优于那些从常氧处理的MSC(Exo(N))。将小鼠骨髓MSCs在缺氧或常氧条件下培养24 h,将条件培养基中的外泌体心内注射入C57BL/6小鼠梗死心脏。Exo(H)组具有显着更高的生存率、更小的疤痕大小和更好的心脏功能恢复。与Exo(N)相比,Exo(H)组梗塞心脏血管密度增加、心肌细胞(CM)凋亡减少、纤维化减少和心脏祖细胞募集增加。与Exo(N)相比,MicroRNA分析显示Exo(H)中具有显着更高水平的miR-210。将miR-210模拟物转染至内皮细胞(EC)和CM中具有与Exo(H)类似的生物效应。缺氧处理MSCs增加了对外泌体分泌至关重要的中性鞘磷脂酶2(nSMase2)的表达。阻断nSMase2的活性导致miR-210分泌减少并消除了Exo(H)的有益作用。总之,缺氧培养增加了MSCs及其分泌的外泌体中的miR-210和nSMase2活性,这至少部分是缺氧处理的细胞来源的外泌体增强心脏保护作用的原因。

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    2018-07-28 维他命
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    2018-04-17 lfyang
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608349, encodeId=eaa016083490a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 16 05:38:00 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2018-01-21 smallant2002
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608349, encodeId=eaa016083490a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 16 05:38:00 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2018-04-04 shock_melon
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608349, encodeId=eaa016083490a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 16 05:38:00 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2018-08-10 sunylz
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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608349, encodeId=eaa016083490a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 16 05:38:00 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-18 三生有幸9135

    学习一下谢谢分享

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608349, encodeId=eaa016083490a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 16 05:38:00 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2018-01-14 cathymary
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608349, encodeId=eaa016083490a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Dec 16 05:38:00 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-16 zwjnj2

    还还还还学习.

    0

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J Endod:搅碎牙髓作为牙髓间充质干细胞来源的成牙本质分化能力研究

通过多种临床探索发现牙髓中存在间充质干细胞(MSCs),这促使牙髓组织的再生成为可能,尽管体外扩展和培养的MSC植入髓腔还存在诸多困难。搅碎的牙髓组织作为牙髓MSCs的来源,可以绕过体外MSC培养调控和技术的复杂性。在此,研究者探讨搅碎牙髓的组织再生能力。

Hepatology:间充质基质细胞可提高乙肝患者生存率!

由于治疗选择比较局限,乙型肝炎病毒(HBV)导致的急性慢性肝衰竭(ACLF)的死亡率很高。但是目前在临床前瞻性研究和临床研究已经证明,选择间充质基质细胞(MSC)的治疗有利于肝损伤患者的恢复。一篇发表在Hepatology的文章对此开展研究,以验证该结论的可靠性。以下是对这项研究的简要介绍。

JASN:自体间充质干细胞增加肾血管病变的皮质灌注!

该研究是第一在人体进行的剂量递增研究,其提供了RVD患者动脉内输注自体MSCs安全性的证据。在没有肾动脉血运重建的情况下输注MSC与肾组织氧合和皮质血流量增加有关。