J Thromb Haemost:妊娠晚期并发症和染色体异常低风险女性抗磷脂抗体阳性的患病率

2020-08-12 MedSci原创 MedSci原创

该研究的队列报告了aPL的高患病率。对既往有LO-PC的女性进行标准和“额外标准”aPL的检测可以提高诊断准确性,从而有助于识别出具有较高复发性妊娠并发症风险的女性。

抗磷脂抗体(aPL)会增加产科并发症的风险。但是,aPL对于妊娠晚期并发症(LO-PC)女性的重要性和患病率需要进一步阐明。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,该研究旨在调查LO-PC女性中aPL的患病率,并将其与正常妊娠女性进行比较。

从2018年8月至2019年8月,该研究共招募了100名LO-PC女性,这些孕妇的染色体异常风险较低且无胎儿异常风险。研究人员将100例妊娠状况良好的女性作为对照组,并对产前筛查的血清样本进行了aPL检测,其中包括标准的和“超标准”的aPL。

与对照组相比,LO-PC女性的aPL患病率显著更高[31/100(31%) vs. 10/100(10%);p<0.001]。更详细地讲,高达26%的LO‐PC妇女有一种aPL呈阳性,总体患病率明显高于对照组(26% vs. 9%;p<0.05)。在单个aPL阳性女性中,她们的aCL IgG(10% vs. 2%;平均值±SD为11±13 vs. 4±9.6 CU;p<0.05)和aPS/PT IgM(15% vs. 6%;平均值±SD为10.2±21.7 vs. 3.7±13.7U;p<0.05)的阳性率和滴度更高。单独检测aPS/PT(IgM/IgG)可以确定17名标准aPL阴性的女性。aPL阳性女性的早产风险显著升高(34-36+6w;10% vs. 8%;p<0.012)。

该研究的队列报告了aPL的高患病率。对既往有LO-PC的女性进行标准和“额外标准”aPL的检测可以提高诊断准确性,从而有助于识别出具有较高复发性妊娠并发症风险的女性。

原始出处:

Silvia G Foddai.et al.The prevalence of antiphospholipid antibodies in women with late pregnancy complications and low‐risk for chromosomal abnormalities.Journal of Thrombosis and Haemostasis.2020.https://doi.org/10.1111/jth.15053

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  5. 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  6. 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    2021-03-01 changfy
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758272, encodeId=35cc1e58272f7, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun Mar 21 07:21:02 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808970, encodeId=87dd8089e0c6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b5f1740478, createdName=littledeath, createdTime=Fri Aug 14 20:08:05 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250704, encodeId=8a5d1250e0443, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Aug 14 10:21:02 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
    2020-12-09 my dream

    学习了

    0

  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1758272, encodeId=35cc1e58272f7, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun Mar 21 07:21:02 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808970, encodeId=87dd8089e0c6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b5f1740478, createdName=littledeath, createdTime=Fri Aug 14 20:08:05 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250704, encodeId=8a5d1250e0443, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Aug 14 10:21:02 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
    2021-03-21 丁鹏鹏
  9. 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    2020-08-14 littledeath

    学习了

    0

  10. 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与aPL阳性的VTE患者相比,aPL阳性的ATE患者可能受益于不同的抗栓方法。为了确定最佳的抗血栓形成策略,必须对具有明确定义的aPL阳性的TE队列进行前瞻性研究。

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系统性红斑狼疮(SLE)是一种不明原因的慢性全身性自身免疫炎性疾病。总体发病率为1:2000。男女比例为1:9,育龄期女性多见。SLE累及肺,肾以及中枢神经系统时更为严重,且为主要死因。SLE的神经精神症状是SLE的主要临床表现而非并发症。 神经精神性狼疮(NPSLE)的发病率为21%到95%。其预后高度可变,预后差主要由以下几个原因导致:1 没有规范的标准和定义;2 没有使用确定的标准评价

Heart:抗磷脂抗体与感染性心内膜炎的栓塞事件之间的相关性分析!

由此可见,aCL和抗β2GPI IgM与EE相关,特别是脑部EE,并可能有助于评估IE的栓塞风险。