Toxicol Sci:研究揭示SnS 2纳米花对小鼠睾丸组织的毒性作用

2017-11-27 Emma MedSci原创

SnS 2纳米花(SnS 2 NFs)已广泛应用于光电和催化领域,然而关于其爆炸和生殖毒性的研究仍不多。

SnS 2纳米花(SnS 2 NFs)已广泛应用于光电和催化领域,然而关于其爆炸和生殖毒性的研究仍不多。研究人员通过腹腔注射调查三种不同大小的SnS 2花(剂量:38mg/Kg;尺寸:50,80和200nm)在小鼠睾丸中暴露4周的效果。

与那些组织中的SnS 2花(200nm)相比,用SnS 2 NFs处理或不处理的小鼠的体重没有差异,且SnS 2 NFs分布于肝,肾,脾,心,脑,睾丸等器官,但是在睾丸组织中发现较多的SnS 2 NFs(50和80 nm)。精子计数、生存分析、组织病理学评价和qRT-PCR检测结果显示,小型SnS 2 NF诱发睾丸组织生殖毒性。在SnS 2 NFs(剂量:38mg/Kg;尺寸:50和80nm)处理组中也观察到MDA水平升高和SOD活性降低。同样,qRT-PCR数据表明,SnS 2 NF可诱导细胞凋亡和炎症反应。尽管与对照组和200 nm组相比,50和80nm组中TNF-α,IL-1β,iNOS和COX-2的促炎症标志物在mRNA水平上表达较高,但50-80 nm组间无统计学意义。

通过腹腔注射SnS 2 NFs(大小:50nm; 0.38mg/Kg,3.8mg/Kg,38mg/Kg)4周,精子数量,存活率和qRT-PCR分析确定SnS 2 NFs在睾丸组织中的重复剂量毒性也以剂量依赖的方式观察到。透射电镜结果显示,睾丸中小型SnS 2 NFs形成的超微结构异常比睾丸中大型SnS 2形成的超微结构异常严重。

该研究表明,SnS 2 NFs激活了炎症反应,诱导鼠睾丸中的细胞凋亡,该研究为SnS 2 NFs的应用和风险分析管理提供了重要参考。
 
原始出处:
Bai D, et al. Effects of intraperitoneal injection of SnS2 flowers on mouse testicle. Toxicol Sci. 2017 Oct 23. doi: 10.1093/toxsci/kfx220. 

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    2017-12-07 虈亣靌

    不错的.学习了!谢谢分享!

    0

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    2017-12-02 虈亣靌

    不错的.学习了!谢谢分享!

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed Nov 29 17:00:32 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368343, encodeId=31cb136834357, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Wed Nov 29 07:21:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265049, encodeId=c2122650498b, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, 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content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:30 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264803, encodeId=115e26480361, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Mon Nov 27 16:39:41 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264802, encodeId=7d2e2648028e, content= 学习学习学习, beContent=null, objectType=article, 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    2017-11-29 Jackie Li

    学习

    0

  5. 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    2017-11-29 zhangph
  6. 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    2017-11-28 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  7. 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    2017-11-28 jihuaijun1112

    学习学习学习

    0

  8. 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    2017-11-27 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

  9. 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    2017-11-27 xiaotao112411

    学习学习学习

    0

  10. 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    2017-11-27 xiaotao112411

    学习学习学习

    0