CCLM:健康中国女性妊娠早期和晚期生化,止血和血液学参数的参考区间

2018-07-31 MedSci MedSci原创

已有研究报道,在不同的妊娠期,母体血液参数会发生相应变化,这些变化主要是由怀孕期间发生的生理变化引起的。如果使用健康成年女性既定的参考区间会导致健康孕妇的错误分类。因此,我们的目的是为妊娠第一和第三三个月的生化,血液和止血参数建立适当的参考区间。 本研究纳入了565名正常怀孕的健康孕妇。收集血样用于妊娠8-12和28-37周的生化分析、全血细胞计数和凝血分析。计算妊娠期间每个参数的中位数和参

已有研究报道,在不同的妊娠期,母体血液参数会发生相应变化,这些变化主要是由怀孕期间发生的生理变化引起的。如果使用健康成年女性既定的参考区间会导致健康孕妇的错误分类。因此,我们的目的是为妊娠第一和第三三个月的生化,血液和止血参数建立适当的参考区间。

本研究纳入了565名正常怀孕的健康孕妇。收集血样用于妊娠8-1228-37周的生化分析、全血细胞计数和凝血分析。计算妊娠期间每个参数的中位数和参考区间(第2.5和第97.5个值),然后与健康成年女性的既定参考区间进​​行比较。

结果显示,甘油三酯,总胆固醇,低密度脂蛋白胆固醇,尿酸,碱性磷酸酶,白细胞,平均血小板体积,纤维蛋白原和D-二聚体参考区间显著增加,总蛋白,白蛋白,血尿素氮,肌酐明显减少,在怀孕期间观察到红细胞,血红蛋白,血细胞比容,血小板计数和凝血酶时间参考间隔。根据'n',大多数变化是在孕早期开始观察的。与建立的参考区间相比,对ALBALPD-Di观察到最大错误分类。

本研究确认了怀孕期间母体血液参数的变化。我们应该在考虑妊娠期的背景下,建议修改大多数血液参数的参考区间。

原始出处:

Jin, Yi, Lu, Jie, Jin, Hong, Reference intervals for biochemical, haemostatic and haematological parameters in healthy Chinese women during early and late pregnancy

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    2018-08-08 易水河

    知之为知之

    0

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    2018-08-01 jeanqiuqiu
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    2018-07-31 phoebeyan520

    学习了学习了,谢谢

    0

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    2018-07-31 神功盖世

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