Neurology:视网膜病变与脑微出血

2017-12-14 zhangfan MedSci原创

研究证实,视网膜微血管症状与单纯视网膜地图样萎缩分别于深层以及脑叶区微出血相关,该结果对进一步研究小血管疾病在认知功能障碍中的作用有重要意义

近日研究人员考察了老年性黄斑变性(AMD)和视网膜微血管症状与脑叶和深部脑微出血 (CMBs)之间的关系。

脑叶区CMB是脑淀粉样血管病(CAA)的重要指征,而β淀粉样蛋白沉积与CAA和AMD有关。深层CMB与高血压相关,而高血压是视网膜微血管症状的主要风险因素。在这项人口基础研究中,2502名志愿者参与,基线时进行双眼数字视网膜成像以评估视网膜微血管病变和AMD,在基线及随访期进行脑MRI成像以确定CMB症状。研究考察了3个视网膜微血管症状:局灶性小动脉狭窄、动静脉穿刺和视网膜病变。研究人员利用多因素逻辑模型考察基线视网膜病理与随访期CMB之间的关系。

研究随访5.2年,461人(18.3%)新发脑微出血,其中293人在脑叶区,168人在脑深层。单纯视网膜地图样萎缩与脑叶区微出血相关(OR,2.59, 95% CI 1.01-6.65)与深层CMB无关。超过2个以上视网膜微血管症状导致深层脑微出血风险增加3倍(95% CI 1.73-5.20),但不会增加脑叶微出血风险。

研究证实,视网膜微血管症状与单纯视网膜地图样萎缩分别于深层以及脑叶区微出血相关,该结果对进一步研究小血管疾病在认知功能障碍中的作用有重要意义。

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    2018-07-01 yinhl1978
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    2017-12-20 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

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    2017-12-18 半夏微凉

    学习了谢谢分享

    0

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    2017-12-16 zutt
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