Diabetes:尽管肥胖但机体的代谢状况依然很健康!秘密竟然是...

2021-11-25 细胞 细胞

活跃的棕色脂肪组织与肥胖人群机体中更为健康的代谢表型有关。

并非所有的肥胖都是一样的,棕色脂肪或许就会带来所有的不同,近日,一篇发表在国际杂志Diabetes上题为“Active Brown Adipose Tissue is Associated With a Healthier Metabolic Phenotype in Obesity的研究报告中,来自维也纳医科大学等机构的科学家们通过研究发现,与机体中没有棕色脂肪的肥胖人群相比,严重超重(肥胖)的人群机体或许也含有活跃的棕色脂肪,这就提示其机体新陈代谢或许更健康,而且使用的能量也更多。相关研究结果表明,棕色脂肪的存在或许可能会保护机体抵御继发性肥胖相关的疾病。

 

图片

PET/CT扫描揭示女性机体中棕色脂肪的分布情况。

图片来源:Public Domain

 

很多年来,科学家们一直在尝试理解为何一些肥胖人群相比类似体重的人群似乎并不太会患上糖尿病高血压等多种疾病,现在看来,所谓的“代谢健康性肥胖”(metabolically healthy obesity)的一个重要因素就是机体棕色脂肪的形式。研究者Florian Kiefer解释道,长期以来棕色脂肪被认为有益于机体的新陈代谢,因为与更为常见的白色储存脂肪不同的是,其能以热量的形式来燃烧能量。婴儿和学步儿童尤其会利用棕色脂肪组织来维持机体体温,而且机体中棕色脂肪的比例会随着机体年龄的增长和体重过重而不断减少。

图片

 

这篇研究报告中,研究者发现,有超过三分之一的严重过重成年人(BMI大于35kg/m2)机体中仍然拥有活跃的棕色脂肪;研究人员首先让志愿者们使用冷却背心暴露在适度的寒冷中,从而激活其体内的棕色脂肪,然后通过PET-CT来对其进行扫描。研究者Kiefe说道,在成年人中,棕色脂肪主要存在于颈部底部和肋骨中;大约一小时的短暂冷刺激就足以激活棕色脂肪了。与体重相近但并未检测到机体中存在棕色脂肪的对照人群相比,拥有棕色脂肪的超重参与者往往会表现出较高的能量消耗,以及较少的有害腹部脂肪、更健康的糖代谢和更少的脂肪肝迹象。

 

图片

图片来源:https://diabetes.diabetesjournals.org/content/early/2021/10/18/db21-0475

 

研究者Kiefer表示,我们发现,拥有棕色脂肪的参与者在几乎所有代谢参数上都表现地更好,尽管其BMI略高一点;而且相关研究数据再次表明,重要的似乎并不仅仅是脂肪组织的数量,更重要的是其质量。实际上,脂肪分布的差异可能会促进机体有利的代谢状况,尤其是,代表高风险糖尿病和心脏病发作的腹部深层脂肪(内脏脂肪)的比例在棕色脂肪组中明显较低,因此可以想象,棕色脂肪代谢活性的增加或许会优先分解并首先会燃烧有害的内脏储存的脂肪,这就是为何目前研究人员正在深入研究来开发激活棕色脂肪的药物疗法的原因了。

综上本文研究结果表明,棕色脂肪组织中18F氟代脱氧葡萄糖(fluorodeoxyglucose,FDG)摄入量的减少或与脂肪组织本身并无关联,而是与较高的内脏脂肪质量有关。总之,活跃的棕色脂肪组织与肥胖人群机体中更为健康的代谢表型有关。

原始出处:

Carsten T. Herz, Oana C. Kulterer, Marlene Prager, et al. Active Brown Adipose Tissue is Associated With a Healthier Metabolic Phenotype in Obesity, Diabetes (2021). DOI:10.2337/db21-0475

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    2021-12-13 ms8426593121538491

    按照代谢对肥胖分类

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1902673, encodeId=577619026e34d, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Jun 04 20:12:53 CST 2022, time=2022-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639991, encodeId=cb9216399917e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Oct 26 11:12:53 CST 2022, time=2022-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079550, encodeId=098510e95507e, content=按照代谢对肥胖分类, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dac2110791, createdName=ms8426593121538491, createdTime=Mon Dec 13 14:19:28 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761787, encodeId=daa51e61787e6, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Jun 11 10:12:53 CST 2022, time=2022-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074898, encodeId=860410e4898ba, content=也许肥胖就是机体的某种代偿机制,值得进一步研究!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/AF43A7988964C1346E091DE08822DCC1/100, createdBy=1b2b1959838, createdName=jiazhoudexue, createdTime=Sun Nov 28 22:57:03 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074063, encodeId=a0ea10e406316, content=海市召开的第107场新冠肺炎疫情防控新闻, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Nov 26 07:12:18 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074016, encodeId=ad6d10e4016b7, content=坚持学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Thu Nov 25 23:04:44 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074007, encodeId=3fe310e40070f, content=就是怎么激活?, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a44885671, createdName=419040982, createdTime=Thu Nov 25 22:36:46 CST 2021, time=2021-11-25, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1902673, encodeId=577619026e34d, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Jun 04 20:12:53 CST 2022, time=2022-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639991, encodeId=cb9216399917e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Oct 26 11:12:53 CST 2022, time=2022-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079550, encodeId=098510e95507e, content=按照代谢对肥胖分类, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dac2110791, createdName=ms8426593121538491, createdTime=Mon Dec 13 14:19:28 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761787, encodeId=daa51e61787e6, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Jun 11 10:12:53 CST 2022, time=2022-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074898, encodeId=860410e4898ba, content=也许肥胖就是机体的某种代偿机制,值得进一步研究!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/AF43A7988964C1346E091DE08822DCC1/100, createdBy=1b2b1959838, createdName=jiazhoudexue, createdTime=Sun Nov 28 22:57:03 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074063, encodeId=a0ea10e406316, content=海市召开的第107场新冠肺炎疫情防控新闻, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Nov 26 07:12:18 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074016, encodeId=ad6d10e4016b7, content=坚持学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Thu Nov 25 23:04:44 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074007, encodeId=3fe310e40070f, content=就是怎么激活?, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a44885671, createdName=419040982, createdTime=Thu Nov 25 22:36:46 CST 2021, time=2021-11-25, status=1, ipAttribution=)]
    2021-11-28 jiazhoudexue

    也许肥胖就是机体的某种代偿机制,值得进一步研究!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1902673, encodeId=577619026e34d, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sat Jun 04 20:12:53 CST 2022, time=2022-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639991, encodeId=cb9216399917e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Oct 26 11:12:53 CST 2022, time=2022-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1079550, encodeId=098510e95507e, content=按照代谢对肥胖分类, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dac2110791, createdName=ms8426593121538491, createdTime=Mon Dec 13 14:19:28 CST 2021, time=2021-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761787, encodeId=daa51e61787e6, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Jun 11 10:12:53 CST 2022, time=2022-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074898, encodeId=860410e4898ba, content=也许肥胖就是机体的某种代偿机制,值得进一步研究!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/AF43A7988964C1346E091DE08822DCC1/100, createdBy=1b2b1959838, createdName=jiazhoudexue, createdTime=Sun Nov 28 22:57:03 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074063, encodeId=a0ea10e406316, content=海市召开的第107场新冠肺炎疫情防控新闻, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Nov 26 07:12:18 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074016, encodeId=ad6d10e4016b7, content=坚持学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Thu Nov 25 23:04:44 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074007, encodeId=3fe310e40070f, content=就是怎么激活?, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a44885671, createdName=419040982, createdTime=Thu Nov 25 22:36:46 CST 2021, time=2021-11-25, status=1, ipAttribution=)]
    2021-11-26 查查佳佳

    海市召开的第107场新冠肺炎疫情防控新闻

    0

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    2021-11-25 SR~young海东

    坚持学习

    0

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    2021-11-25 419040982

    就是怎么激活?

    0

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