Gastric Cancer:二甲双胍可降低糖尿病患者患胃癌的风险

2020-07-04 MedSci原创 MedSci原创

糖尿病(DM)会增加动脉粥样硬化等并发症和胃癌的风险。胃癌是最常人群中罪常见的癌症。尽管胃癌的存活率有所提高,但疾病负担仍然很高。因此,本项研究旨在探究二甲双胍在降低糖尿病患者患胃癌的风险中的作用。 

背景及目的

糖尿病(DM)增加动脉粥样硬化并发症和胃癌风险。胃癌是最常人群中罪常见的癌症。尽管胃癌的存活率有所提高,但疾病负担仍然很高。因此,本项研究旨在探究二甲双胍降低糖尿病患者患胃癌的风险中的作用。

 

方法

这项回顾性研究使用国家健康保险局数据库调查了韩国人群中二甲双胍的使用与胃癌发病率之间的关系。研究人员将2002-2003年的40-80岁年龄段的参与者纳入本项研究。研究人群分为三类:使用二甲双胍糖尿病患者,不使用二甲双胍的糖尿病患者和非糖尿病患者(无糖尿病组)。

 

结果

最终分析总共包括347895名参与者(14922名二甲双胍非使用者,9891名二甲双胍使用者和323,082名非糖尿病患者)。中位随访时间为12.7年。服用二甲双胍胃癌累积发生率最高,而使用二甲双胍的非糖尿病组则最低(非服用二甲双胍的男性为3.75 vs. 1.97%,二甲双胍为2.91 vs. 1.53%,以及2.54 vs 0.95%(无DM组)。与未服用二甲双胍的人相比,二甲双胍使用者和 DM组患胃癌的风险比(95%置信区间)分别0.710(0.579–0.870)和0.879(0.767–1.006),以及0.700(0.499–0.981)

结论

本项研究证实人群中使用二甲双胍的DM患胃癌的风险较低。

原始出处:

Joungyoun Kim. Et al. Metformin use reduced the risk of stomach cancer in diabetic patients in Korea: an analysis of Korean NHIS-HEALS database. Gastric Cancer.2020.

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    2021-06-10 skhzy
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    2020-08-29 许安
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1712480, encodeId=9a691e12480bc, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jun 08 05:31:04 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893676, encodeId=b73e18936e6d4, content=<a href='/topic/show?id=4fc4e85161' target=_blank style='color:#2F92EE;'>#gastric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7851, encryptionId=4fc4e85161, topicName=gastric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Thu Jun 10 02:31:04 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2073050, encodeId=e5f520e30507f, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Aug 29 03:31:04 CST 2020, time=2020-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474952, encodeId=bdce14e495264, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Jul 06 01:31:04 CST 2020, time=2020-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=801210, encodeId=ec978012100b, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>降低实体瘤风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/02/28/889a1910ded7780f3c049b354f1648b7.jpg, createdBy=2a791737770, createdName=mswert122, createdTime=Sat Jul 04 18:56:31 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041533, encodeId=d0c210415333d, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jul 04 13:31:04 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043201, encodeId=0e7f1043201c8, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jul 04 13:31:04 CST 2020, time=2020-07-04, status=1, ipAttribution=)]
    2020-07-04 mswert122

    #二甲双胍#降低实体瘤风险

    0

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    2020-07-04 misszhang

    二甲双胍,神药!

    0

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    2020-07-04 misszhang

    谢谢MedSci提供最新的资讯

    0

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