吃辅酶Q10是交智商税吗?LANCET子刊:对于糖尿病患者还真不是!每天服用100-200mg最佳!

2022-08-04 MedSci原创 MedSci原创

eClinicalMedicine:补充辅酶Q10对血糖控制的影响:一项分级评估的系统回顾和随机对照试验的剂量-反应荟萃分析

在过去的几十年里,心血管疾病(CVD)仍然是全球死亡和残疾的主要原因,心血管疾病死亡人数逐年稳步增加。2019年,约有5.23亿成年人患有心血管疾病,大约是1990年的两倍。CVD的发展主要是由心脏代谢危险因素驱动的,例如葡萄糖代谢紊乱。葡萄糖代谢紊乱的患者发生高血糖相关性CVD和代谢性疾病(包括糖尿病,肥胖,血脂异常)的风险很高。越来越多的证据表明,血糖控制可以有效降低心血管疾病和代谢疾病的风险。

辅酶Q10(CoQ10),也称为泛醌,是一种类似于维生素的脂溶性苯醌。在正常的生理条件下,内源性合成被认为是主要来源。然而,随着年龄的增长,CoQ10的合成能力下降,无法满足健康成年人的需求。此外,CoQ10的平均膳食摄入量仅为每天3-6毫克,远低于对CoQ10的需求。CoQ10作为营养补充剂,具有广泛的生物学作用,包括抗氧化、维持正常的血压和胆固醇浓度、维持正常的认知功能、改善胰岛素抵抗等。然而过往的综述报告辅酶Q10对血糖控制的影响并不一致,也尚未有关于探讨辅酶Q10的最佳摄入量用于血糖控制的综述。本研究旨在研究CoQ10对血糖控制的疗效,并通过整合随机对照试验(RCT)的现有证据来评估剂量-反应关系。

本次荟萃分析最终纳入了40项研究(n = 2424名参与者)。CoQ10显著降低空腹血糖(WMD: -5.22 [95% CI: -8.33, -2.11] mg/dl;P <0.001;I2 = 95.10%)、空腹胰岛素(-1.32[-2.06,-0.58] μIU / ml;P <0.001;I2=78.86%), HbA1c (-0.12% [-0.23, -0.01];P = 0.04;I2=49.10%), HOMA-IR (-0.69 [- 1.50,-0.38];P < 0.001;I2 = 88.80%)。在异质性较低的糖尿病中,CoQ10对预后的影响更大。

“U”型剂量-反应关系曲线显示,100-200 mg/天的CoQ10可显著降低空腹血糖(χ2 = 12.08, p非线性=0.002)、空腹胰岛素(χ2 = 9.73, 非线性p =0.008)、糖化血红蛋白(χ2 = 6.00, 非线性p =0.049)、HOMA-IR (χ2 = 25.89, 非线性p <0.001)。

总的来说,本研究结果发现,补充CoQ10可能对血糖控制有益,特别是在糖尿病患者中。每天服用100-200毫克的CoQ10可以达到血糖控制的最大益处。这些发现增加了有关补充CoQ10对血糖控制的有益作用的新信息,并有利于为血糖障碍患者推荐的每日摄入CoQ10建立营养指南

 

原文来源:

Ying Liang, Effects of coenzyme Q10 supplementation on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. eClinicalMedicine 2022;52: 101602 Published online xxx https://doi.org/10.1016/j. eclinm.2022.101602

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    2024-02-03 carrotlyl 来自北京

    神药

    0

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    2022-08-20 drwjr
  3. [GetPortalCommentsPageByObjectIdResponse(id=2185712, encodeId=93362185e12ad, content=神药, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sat Feb 03 21:14:37 CST 2024, time=2024-02-03, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1716498, encodeId=5e671e164981f, content=<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104f32235338, createdName=drwjr, createdTime=Sat Aug 20 22:14:32 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2124700, encodeId=da9c2124e003d, content=吃<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>是交<a href='/topic/show?id=1aa5105835d0' target=_blank style='color:#2F92EE;'>#智商税#</a>吗?LANCET子刊:对于<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>患者还真不是!每天服用100-200mg最佳!, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10), TopicDto(id=105835, encryptionId=1aa5105835d0, topicName=智商税), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Mon Apr 10 01:24:07 CST 2023, time=2023-04-10, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1831624, encodeId=c97818316240d, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 28 04:14:32 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1240244, encodeId=8d741240244d3, content=原来这么有用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fdae2296693, createdName=121f9e9am47(暂无昵称), createdTime=Mon Aug 22 10:32:26 CST 2022, time=2022-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323023, encodeId=89a3132302347, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475323, encodeId=7d4d14e532369, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244065, encodeId=26411244065d6, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Thu Aug 04 13:14:32 CST 2022, time=2022-08-04, status=1, ipAttribution=)]
    2023-04-10 侠胆医心 来自上海

    #辅酶Q10#是交#智商税#吗?LANCET子刊:对于#糖尿病#患者还真不是!每天服用100-200mg最佳!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2185712, encodeId=93362185e12ad, content=神药, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sat Feb 03 21:14:37 CST 2024, time=2024-02-03, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1716498, encodeId=5e671e164981f, content=<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104f32235338, createdName=drwjr, createdTime=Sat Aug 20 22:14:32 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2124700, encodeId=da9c2124e003d, content=吃<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>是交<a href='/topic/show?id=1aa5105835d0' target=_blank style='color:#2F92EE;'>#智商税#</a>吗?LANCET子刊:对于<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>患者还真不是!每天服用100-200mg最佳!, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10), TopicDto(id=105835, encryptionId=1aa5105835d0, topicName=智商税), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Mon Apr 10 01:24:07 CST 2023, time=2023-04-10, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1831624, encodeId=c97818316240d, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 28 04:14:32 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1240244, encodeId=8d741240244d3, content=原来这么有用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fdae2296693, createdName=121f9e9am47(暂无昵称), createdTime=Mon Aug 22 10:32:26 CST 2022, time=2022-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323023, encodeId=89a3132302347, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475323, encodeId=7d4d14e532369, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244065, encodeId=26411244065d6, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Thu Aug 04 13:14:32 CST 2022, time=2022-08-04, status=1, ipAttribution=)]
    2022-08-28 howi
  5. [GetPortalCommentsPageByObjectIdResponse(id=2185712, encodeId=93362185e12ad, content=神药, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sat Feb 03 21:14:37 CST 2024, time=2024-02-03, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1716498, encodeId=5e671e164981f, content=<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104f32235338, createdName=drwjr, createdTime=Sat Aug 20 22:14:32 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2124700, encodeId=da9c2124e003d, content=吃<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>是交<a href='/topic/show?id=1aa5105835d0' target=_blank style='color:#2F92EE;'>#智商税#</a>吗?LANCET子刊:对于<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>患者还真不是!每天服用100-200mg最佳!, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10), TopicDto(id=105835, encryptionId=1aa5105835d0, topicName=智商税), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Mon Apr 10 01:24:07 CST 2023, time=2023-04-10, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1831624, encodeId=c97818316240d, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 28 04:14:32 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1240244, encodeId=8d741240244d3, content=原来这么有用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fdae2296693, createdName=121f9e9am47(暂无昵称), createdTime=Mon Aug 22 10:32:26 CST 2022, time=2022-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323023, encodeId=89a3132302347, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475323, encodeId=7d4d14e532369, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244065, encodeId=26411244065d6, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Thu Aug 04 13:14:32 CST 2022, time=2022-08-04, status=1, ipAttribution=)]
    2022-08-22 121f9e9am47(暂无昵称)

    原来这么有用啊

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2185712, encodeId=93362185e12ad, content=神药, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sat Feb 03 21:14:37 CST 2024, time=2024-02-03, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1716498, encodeId=5e671e164981f, content=<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104f32235338, createdName=drwjr, createdTime=Sat Aug 20 22:14:32 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2124700, encodeId=da9c2124e003d, content=吃<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>是交<a href='/topic/show?id=1aa5105835d0' target=_blank style='color:#2F92EE;'>#智商税#</a>吗?LANCET子刊:对于<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>患者还真不是!每天服用100-200mg最佳!, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10), TopicDto(id=105835, encryptionId=1aa5105835d0, topicName=智商税), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Mon Apr 10 01:24:07 CST 2023, time=2023-04-10, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1831624, encodeId=c97818316240d, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 28 04:14:32 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1240244, encodeId=8d741240244d3, content=原来这么有用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fdae2296693, createdName=121f9e9am47(暂无昵称), createdTime=Mon Aug 22 10:32:26 CST 2022, time=2022-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323023, encodeId=89a3132302347, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475323, encodeId=7d4d14e532369, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244065, encodeId=26411244065d6, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Thu Aug 04 13:14:32 CST 2022, time=2022-08-04, status=1, ipAttribution=)]
    2022-08-06 晓辰
  7. [GetPortalCommentsPageByObjectIdResponse(id=2185712, encodeId=93362185e12ad, content=神药, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sat Feb 03 21:14:37 CST 2024, time=2024-02-03, status=1, ipAttribution=北京), GetPortalCommentsPageByObjectIdResponse(id=1716498, encodeId=5e671e164981f, content=<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104f32235338, createdName=drwjr, createdTime=Sat Aug 20 22:14:32 CST 2022, time=2022-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2124700, encodeId=da9c2124e003d, content=吃<a href='/topic/show?id=be3193e20cd' target=_blank style='color:#2F92EE;'>#辅酶Q10#</a>是交<a href='/topic/show?id=1aa5105835d0' target=_blank style='color:#2F92EE;'>#智商税#</a>吗?LANCET子刊:对于<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>患者还真不是!每天服用100-200mg最佳!, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93720, encryptionId=be3193e20cd, topicName=辅酶Q10), TopicDto(id=105835, encryptionId=1aa5105835d0, topicName=智商税), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Mon Apr 10 01:24:07 CST 2023, time=2023-04-10, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1831624, encodeId=c97818316240d, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 28 04:14:32 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1240244, encodeId=8d741240244d3, content=原来这么有用啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=fdae2296693, createdName=121f9e9am47(暂无昵称), createdTime=Mon Aug 22 10:32:26 CST 2022, time=2022-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323023, encodeId=89a3132302347, content=<a href='/topic/show?id=a38660034ac' target=_blank style='color:#2F92EE;'>#智商#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60034, encryptionId=a38660034ac, topicName=智商)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475323, encodeId=7d4d14e532369, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Aug 06 01:14:32 CST 2022, time=2022-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244065, encodeId=26411244065d6, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Thu Aug 04 13:14:32 CST 2022, time=2022-08-04, status=1, ipAttribution=)]
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    2022-08-04 younei

    lancet上果然牛,感谢梅斯更新及时

    0

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