Brain:自发性低颅压补片治疗后首发反应的预测因素

2017-06-21 MedSci MedSci原创

自发性颅内低血压由脑脊液漏引起。目前,自发性颅内低血压的选择治疗是硬膜外血液补片,其补片反应因人而异,并无明显预后。本研究旨在确定自发性颅内低血压患者硬膜外补片反应的预测因子。

背景:自发性颅内低血压由脑脊液漏引起。目前,自发性颅内低血压的选择治疗是硬膜外血液补片,其补片反应因人而异,并无明显预后。本研究旨在确定自发性颅内低血压患者硬膜外补片反应的预测因子。


方法:研究回顾了2007年1月1日至2014年7月1日期间在院接受靶向硬膜外血液补片治疗的自发性颅内低血压患者的病例,其结果为首次发生硬膜外补片反应。研究人员分析了人口统计学,临床表现,神经影像发现(非对比重度T2加权磁共振骨髓造影和脑磁共振成像)和血容量作为潜在的结果预测因子。测试了重要的预测因子,并用决策树来构建预测模型。共纳入150例自发性颅内低血压患者进行最终分析。

结果:所有患者第一个靶向硬膜外血液补片反应率为58.7%。注射血容量较大的患者(≥22.5对<22.5 ml),反应率较高(67.9%,47.0%,P = 0.01)。在脑和脊髓磁共振成像研究中,重要预测因素包括硬膜外脑脊液采集长度(<8对≥8段; 72.5%对37.3%,优势比= 4.4,95%置信区间:2.2-8.9,P <0.001)和脑中脑角(≥40°,<40°; 71.3%,37.5%,优势比= 4.1,95%置信区间2.1-8.3,P <0.001)。决策树分析显示,前期硬膜外CSF收集涉及<8段和注射血容量≥22.5ml的患者的反应率为80.0%。前硬膜外脑脊液采集≥8段,中脑角角度<40°的患者的反应率为21.2%。这三个变量预测了71.3%的患者首例硬膜外血液补片反应。

结论:脑和脊髓神经影像学检查结果和硬膜外血液血容量可用于预测自发性颅内低血压患者硬膜外血液补片首发反应。

原文出处:
Wu JW,Hseu SS,Fuh JL,et al.Factors predicting response to the first epidural blood patch in spontaneous intracranial hypotension.Brain. 2017 Feb;140(Pt 2):344-352. doi: 10.1093/brain/aww328.

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