JAMA Intern Med:绝经后女性创伤性骨折、非创伤性骨折与后续骨折风险研究

2021-06-10 MedSci原创 MedSci原创

对于绝经后女性,无论初次骨折为创伤性或非创伤性骨折,后续的骨折风险都显著增加。


每2个绝经后女性中,就有1人会在余生中出现骨质疏松相关骨折。中老年骨折与独立性丧失、慢性疼痛、残疾、生活质量下降和死亡风险增加相关。非创伤性骨折或脆性骨折是后续骨折的高危险因素。近日研究人员考察了在50-64岁的绝经后女性中,创伤性骨折与后续骨折风险的关系。

WHI研究为一项前瞻性观察性研究,来自美国40个临床中心的50至79岁的绝经后女性参与。总计收集了66874名参与者数据,平均随访8.1年。研究的主要终点为临床骨折事件,根据骨折的原因分为外伤性或非外伤性。

无临床骨折事件发生女性参与者的平均年龄为63.1岁,发生骨折事件参与者平均年龄为65.3岁,7142名参与者(10.7%)在研究随访期间经历了偶发骨折。初次骨折后继发骨折的校正危险比(aHR)为1.49。在初次骨折为创伤性骨折的女性患者中,初次骨折增加了后续骨折风险(aHR=1.25)。在初次骨折为非外伤性骨折的女性中,初次骨折后后续骨折风险更高(aHR=1.52)。

研究认为,对于绝经后女性,无论初次骨折为创伤性或非创伤性骨折,后续的骨折风险都显著增加。

原始出处:

Carolyn J. Crandall et al. Risk of Subsequent Fractures in Postmenopausal Women After Nontraumatic vs Traumatic Fractures. JAMA Intern Med. June 06,2021.

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    2022-02-28 amyloid
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  5. 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  6. 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createdName=旺医, createdTime=Fri Jun 11 00:01:22 CST 2021, time=2021-06-11, status=1, ipAttribution=)]
    2021-06-12 zxxiang
  9. 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createdName=旺医, createdTime=Fri Jun 11 00:01:22 CST 2021, time=2021-06-11, status=1, ipAttribution=)]
    2021-06-11 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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