JAMA Netw Open:老年女性每天轻运动5小时,行动障碍发生风险降低40%

2021-02-25 MedSci原创 MedSci原创

迄今为止,几乎所有关于身体活动(PA)的证据,包括2018年PA指南中的证据,都集中在高强度的PA上。有研究显示,中等强度PA计划增加了下肢的身体功能,减少了意外活动的致残率。

预计到2035年,美国65岁以上人口将达到7800万,在美国历史上首次超过18岁以下的儿童。美国人口老龄化的部分原因是预期寿命的增加,所有种族/族裔的女性比男性拥有近5年的长寿优势。然而,在美国,27%65岁以上人口患有行动障碍,比如行走或爬楼梯的严重困难,也是美国最主要的致残因素。24%的老年女性无法行走23个街区,而老年男性的比例为14%

迄今为止,几乎所有关于身体活动(PA)的证据,包括2018PA指南中的证据,都集中在高强度的PA上。有研究显示,中等强度PA计划增加了下肢的身体功能,减少了意外活动的致残率。那么,轻度身体活动(LPA),如休闲散步或从事大多数日常生活活动,是否能降低行动障碍的风险,尚不清楚。

近日,发表在JAMA Netw Open杂志的一项研究显示,轻度运动可以保持行动能力,尤其对绝经后女性。在这项前瞻性队列研究中,研究人员收纳了在20123月至20144月期间参加 "客观测量身体活动和血管健康研究的女性,该研究是 "妇女健康倡议 "的辅助研究,随访至2018331日。"妇女健康倡议是一项多站点人群研究,从美国40个临床站点招募。该研究收纳了573563岁及以上的女性,平均年龄为78.5岁,其中有2811名白人参与,数据分析时间为20188月至20195月。

根据分析样本中的分布情况,将LPA的每日平均时数分为四分位数:第一分位数[Q1]LPA的平均时数为0.64.0小时/天;第二分位数[Q2]LPA的平均时数4.04.8小时/天;第三分位数[Q3]LPA的平均时数4.85.6小时/天;第四分位数[Q4]LPA的平均时数5.610.4小时/天。

结果显示,与轻强度体力活动第四分位数的女性相比,在第二分位数(多变量危险比[HR]0.7895% CI0.67-0.90)、第三分位数(HR0.6095% CI0.51-0.71)和第四分位数(HR0.6095% CI0.51-0.71)中观察到较低的意外行动障碍风险。在第二分位数(多变量HR0.7295% CI0.60-0.85)、第三分位数(HR0.5595% CI0.46-0.67)和第四分位数(HR0.5295% CI0.42-0.63)中,这种有益的关联对持续性活动障碍更强(P < .001)。进一步分层分析显示,与体重指数为30.0或更高的女性相比,较轻体重指数小于30.0的女性(HR0.7395% CI0.66-0.82)的关联性更强(HR0.9195% CI0.79-1.04)。

总之,LPA的第二低分位数开始,随着LPA的增加,发生意外行动障碍的风险降低。与LPA最低四分位数的女性相比,LPA最高四分位数的女性发生行动障碍的风险降低了40%,持续行动障碍的风险降低了48%因此,高水平的LPA对于降低行动不便的风险是不必要的,因为在每天大约5小时的LPA中没有显著性改变。

原始出处:

Nicole L. Glass, MPH1; John Bellettiere, PhD1Purva Jain, MPH1; et al.Evaluation of Light Physical Activity Measured by Accelerometry and Mobility Disability During a 6-Year Follow-up in Older Women.JAMA Netw Open. 2021;4(2):e210005. doi:10.1001/jamanetworkopen.2021.0005

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    2021-08-18 feather89
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    2021-11-07 canlab
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    2021-04-01 ms1000001691009964

    学习

    0

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    2021-03-26 ms2000001361349190

    学习

    0

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    2021-02-26 王静6093

    学习了!!!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1728842, encodeId=88191e2884267, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Aug 18 05:54:03 CST 2021, time=2021-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820713, encodeId=0ad91820e13a9, content=<a href='/topic/show?id=0c6a1009105e' target=_blank style='color:#2F92EE;'>#风险降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100910, encryptionId=0c6a1009105e, topicName=风险降低)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd18451, createdName=xre2008, createdTime=Wed Aug 25 02:54:03 CST 2021, time=2021-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734323, encodeId=d3d81e343232c, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Sun Nov 07 04:54:03 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=953055, encodeId=2d2d95305514, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75a45462359, createdName=ms1000001691009964, createdTime=Thu Apr 01 13:45:01 CST 2021, time=2021-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951419, encodeId=50e4951419c0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dffa5465843, createdName=ms2000001361349190, createdTime=Fri Mar 26 16:56:23 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927279, encodeId=16ef92e2796f, content=学习了!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJIia2Eia4Q2ZUFFIzd66CsiaK1hKHKibOvnMBXTgu4g232mibd9ViaFCgicwEoOcoMaREYgFIZva2DQl0cQ/132, createdBy=078c5363000, createdName=王静6093, createdTime=Fri Feb 26 07:43:35 CST 2021, time=2021-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036474, encodeId=8f3f10364e490, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 16:54:03 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-02-25 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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