Clin Cancer Res:循环肿瘤细胞亚型和T细胞数量可预测转移性泌尿生殖道癌患者的预后

2021-01-26 MedSci原创 MedSci原创

循环肿瘤细胞(CTC)作为一种微创液体活检技术正在被广泛研究,它有望改善癌症患者的风险分层,有助于临床医生为患者制定更合适的治疗方案。

循环肿瘤细胞(CTC)作为一种微创液体活检技术正在被广泛研究,它有望改善癌症患者的风险分层,有助于临床医生为患者制定更合适的治疗方案。CTC的一个重要特征是允许对单个恶性细胞形态和标志物表达进行数字病理分析。本研究比较了一组接受联合免疫治疗的转移性泌尿生殖道(mGU)癌患者的CTC特征和T细胞计数与生存终点的关系。

本研究评估的CTC的生物标志物包括pan-CK/CD45/PD-L1/DAPI,T细胞的包括CD4/CD8/Ki-67/DAPI。方差分析用于比较不同时间点的CTC负荷和T细胞数量。

基线和第2个疗程后CTC负荷对患者预后的影响

2016年12月-2019年1月,共检测了81例患者的183份样本。基线时,在75%的患者样本中发现了CTC。基线CTC负荷与总生存期(OS)缩短有关(p=0.022),但与治疗无关。

检出特殊亚型细胞对患者预后的影响

本研究共检测到五种形态学亚型,其中两种特殊亚型在基线和治疗期间都具有独特的细胞特征,与OS较差相关(0.9-2.3 vs 2-8.2 个月;p<0.0001-0.013)。在治疗过程中,CTC异质性增加,提示OS可能会变得更差(p=0.045)。

基线CD4/CD8 T细胞数量对患者预后的影响

在治疗过程中,检出PD-L1阳性CTC的患者治疗后的OS较差(p<0.01)。基线和治疗过程中CD4/CD8计数低也与OS较差和缓解类型相关。

总之,对于转移性泌尿生殖道癌患者,较短的生存期可能与基线时高CTC计数、存在特定形态的CTC亚型、PD-L1阳性CTC和CD4/8 T细胞少有关。未来的研究有必要进一步验证CTC的异质性和特定形态的CTC检测对预后的预测作用。

原始出处:

Chalfin Heather J,Pramparo Tiziano,Mortazavi Amir et al. Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer. Clin Cancer Res, 2020.https://doi.org/10.1158/1078-0432.CCR-20-2891

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1706423, encodeId=7c841e06423fb, content=<a href='/topic/show?id=267e6911875' target=_blank style='color:#2F92EE;'>#生殖道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69118, encryptionId=267e6911875, topicName=生殖道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e9f31248425, createdName=124984e7m93暂无昵称, createdTime=Sat Feb 27 03:56:27 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313076, encodeId=6f6813130e649, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Jan 28 08:56:27 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386697, encodeId=73c9138669e6c, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Jan 28 08:56:27 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580988, encodeId=8cd1158098836, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jan 28 08:56:27 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920286, encodeId=38ce92028641, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55555437851, createdName=曹江波, createdTime=Wed Jan 27 14:11:30 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920135, encodeId=a3b792013517, content=Mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=969d2873055, createdName=181283b088m, createdTime=Tue Jan 26 22:45:34 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920082, encodeId=10999200826e, content=挺好的研究思路!, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erKxFhGouZU0Yb0lpe15aXJ8wfM3JNnKd7wExtUwZXGMicwDJQOfIEJ7azEyicbbwvwIQ6oOHoYEKRA/132, createdBy=f0ee2175800, createdName=daisy-422, createdTime=Tue Jan 26 18:50:21 CST 2021, time=2021-01-26, status=1, ipAttribution=)]
    2021-01-27 曹江波

    值得学习

    0

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    2021-01-26 181283b088m

    Mark

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1706423, encodeId=7c841e06423fb, content=<a href='/topic/show?id=267e6911875' target=_blank style='color:#2F92EE;'>#生殖道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69118, encryptionId=267e6911875, topicName=生殖道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e9f31248425, createdName=124984e7m93暂无昵称, createdTime=Sat Feb 27 03:56:27 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313076, encodeId=6f6813130e649, content=<a href='/topic/show?id=4ce783062c7' target=_blank style='color:#2F92EE;'>#肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83062, encryptionId=4ce783062c7, topicName=肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Thu Jan 28 08:56:27 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386697, encodeId=73c9138669e6c, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Jan 28 08:56:27 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580988, encodeId=8cd1158098836, content=<a href='/topic/show?id=183c5045ed0' target=_blank style='color:#2F92EE;'>#循环肿瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50457, encryptionId=183c5045ed0, topicName=循环肿瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d2016667446, createdName=thinkibmz_44722599, createdTime=Thu Jan 28 08:56:27 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920286, encodeId=38ce92028641, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55555437851, createdName=曹江波, createdTime=Wed Jan 27 14:11:30 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920135, encodeId=a3b792013517, content=Mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=969d2873055, createdName=181283b088m, createdTime=Tue Jan 26 22:45:34 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920082, encodeId=10999200826e, content=挺好的研究思路!, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erKxFhGouZU0Yb0lpe15aXJ8wfM3JNnKd7wExtUwZXGMicwDJQOfIEJ7azEyicbbwvwIQ6oOHoYEKRA/132, createdBy=f0ee2175800, createdName=daisy-422, createdTime=Tue Jan 26 18:50:21 CST 2021, time=2021-01-26, status=1, ipAttribution=)]
    2021-01-26 daisy-422

    挺好的研究思路!

    0

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