JCEM:袖状胃切除术后早期免疫细胞计数、代谢和功能的变化

2021-09-16 网络 网络

在LSG手术后前三个月,就会诱导免疫细胞的组成和代谢发生显著变化。需要进一步评估减肥手术对免疫代谢的影响以及对宿主防御和代谢疾病的影响。

腹腔镜袖状胃切除术(LSG)是一种有效的肥胖症治疗方法,可以持续减轻体重并改善与肥胖症相关的并发症和炎症。然而,LSG对免疫功能和代谢的影响尚未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在归纳LSG后血液生物标志物、白细胞组成和基因表达的纵向变化。


前瞻性数据是从一个机构的23名登记的受试者中收集的。从术前基线到一年,研究人员每三个月随访间隔观察受试者体重、合并症和血液生物标志物和白细胞亚群趋势的参数。研究人员对来自研究前六名受试者(基线和手术后三个月)的全血样本对进行RNA测序,以确定与接受LSG相关的全基因组表达变化。

LSG导致三个月时受试者平均体重显著减轻(18.1%),糖尿病受试者的HbA1c降低。LSG后前三个月临床炎症和激素生物标志物就有所改善。由于绝对中性粒细胞计数减少,研究人员观察到LSG受试者中性粒细胞-淋巴细胞比率降低。全血差异基因富集分析表明,三个月后,LSG不仅导致了炎症细胞因子通路的转录组变化,而且与能量代谢相关的几个关键代谢途径也有转录组变化。
 
由此可见,在LSG手术后前三个月,就会诱导免疫细胞的组成和代谢发生显著变化。需要进一步评估减肥手术对免疫代谢的影响以及对宿主防御和代谢疾病的影响。

原始出处:

Tammy Lo.et al.Early changes in immune cell count, metabolism, and function following sleeve gastrectomy: a prospective human study.JCEM.2021.https://doi.org/10.1210/clinem/dgab673

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    2022-03-15 仁心济世
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    2022-04-07 achengzhao
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    2021-09-18 bshuang
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    2021-09-17 小小的丁香花

    精神因素所致?

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