NEJM:羟氯喹相关的牛眼黄斑病变-病例报道

2019-04-25 xing.T 网络

视野检查显示环形暗视,光学相干断层扫描的视网膜成像显示光感受器和视网膜色素上皮的相应损失,这些发现与羟氯喹毒性一致。

患者为一名60岁的女性,因双眼视野中出现中央盲点而就诊。她有类风湿性关节炎病史,服用羟氯喹,以每日400mg的剂量,治疗14年。

两只眼睛的视力均为20/20。视网膜检查显示右眼(如图A所示)和左眼(如图B所示)均出现了色素减退的牛眼图案。



视野检查显示环形暗视,光学相干断层扫描的视网膜成像显示光感受器和视网膜色素上皮的相应损失,这些发现与羟氯喹毒性一致。

该患者将羟氯喹转换为甲氨蝶呤6个月后,患者的眼部病情保持稳定。 
 
原始出处:

Yasha S. Modi,et al.Bull’s-Eye Maculopathy Associated with Hydroxychloroquine.N Engl J Med 2019;https://www.nejm.org/doi/full/10.1056/NEJMicm1412167

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    2019-04-26 muzishouyi
  3. [GetPortalCommentsPageByObjectIdResponse(id=1700539, encodeId=0ec91e00539c5, content=<a href='/topic/show?id=a959103143df' target=_blank style='color:#2F92EE;'>#黄斑病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103143, encryptionId=a959103143df, topicName=黄斑病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=209430152341, createdName=liuli5089, createdTime=Mon Aug 05 06:23:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525161, encodeId=8ad8152516145, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Fri Apr 26 23:23:00 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034801, encodeId=e82d1034801ab, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Apr 25 11:23:00 CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365223, encodeId=677336522316, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Apr 25 08:54:50 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
    2019-04-25 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1700539, encodeId=0ec91e00539c5, content=<a href='/topic/show?id=a959103143df' target=_blank style='color:#2F92EE;'>#黄斑病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103143, encryptionId=a959103143df, topicName=黄斑病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=209430152341, createdName=liuli5089, createdTime=Mon Aug 05 06:23:00 CST 2019, time=2019-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525161, encodeId=8ad8152516145, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Fri Apr 26 23:23:00 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034801, encodeId=e82d1034801ab, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Apr 25 11:23:00 CST 2019, time=2019-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365223, encodeId=677336522316, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Apr 25 08:54:50 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
    2019-04-25 龙胆草

    学习谢谢分享

    0

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