Inflammatory Bowel Diseases:克罗恩病患儿的身高发育障碍,男女有别!

2021-07-11 MedSci原创 MedSci原创

近年来,克罗恩病(CD) 在儿童中发病率越来越高,严重影响了儿童的生长发育,尤其是在男性中。然而,CD的发病机制尚未完全明确,可能与免疫,感染,遗产等因素有关。

近年来,克罗恩病(CD) 儿童中发病率越来越高,严重影响了儿童的生长发育,尤其是在男性中。然而,CD的发病机制尚未完全明确,可能与免疫感染,遗产等因素有关。在儿童CD中,确定骨龄(BA)可以在骨骼成熟度的背景下对身高增长进行有临床意义的解释。

克罗恩病高倍显微镜成像

近日,发表在Inflammatory Bowel Diseases杂志的一项研究评估了CD儿童生长障碍的性别差异,以及与身高增长相关的因素。结果揭示,不同的临床变量对男性患者与女性患者的身高增长影响具有显著差异,强调需要制定针对克罗恩病儿童的性别差异治疗策略。

来自康奈尔医学院的研究者对113 名克罗恩病患者与性别身高增长相关的一系列变量进行探究,例如疾病特征、发病症状和某些药物的使用。参与者符合骨龄(BA≥ 4 2 个月且≤ 12 岁的女性患者,骨龄(BA≥ 5 年且≤ 14 岁的男性患者。

结果显示, 41 女性患者中,在诊断时将炎症性肠病初步分类为克罗恩病或肛周疾病与更好的生长有关。然而,患者报告关节疼痛或使用益生菌或硫唑嘌呤/6-巯基嘌呤与生长不良有关。

身高障碍与药物使用之间的关系.

然而,与身高增长相关的变量在72 男性患者中有着很大的不同。患者报告生长不良或使用英夫利昔单抗、生物制剂、甲氨蝶呤或维生素 D 与更好的生长有关。最初将炎症性肠病归类为克罗恩病或患者报告出现厌食症或口腔溃疡与较差的生长发育有关。

研究者表示,性别特异性分子途径导致克罗恩病患儿的生长障碍,而且这些性别特异性分子途径对目前用于治疗小儿克罗恩病的药物的反应可能存在差异。性别很可能是未来治疗决策的重要决定因素,这将代表着小儿克罗恩病临床决策的重大进展。

原始出处

Neera Gupta et al, Clinical Variables Associated With Statural Growth in Pediatric Crohn's Disease Differ by Sex (The Growth Study)Inflammatory Bowel Diseases (2020). DOI: 10.1093/ibd/izaa220

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    2021-09-15 yuandd
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createdName=cmj8wellington, createdTime=Sat Jun 04 07:16:00 CST 2022, time=2022-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977445, encodeId=100e19e74451b, content=<a href='/topic/show?id=57613630b9' target=_blank style='color:#2F92EE;'>#Bow#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3630, encryptionId=57613630b9, topicName=Bow)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Wed Sep 15 14:16:00 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057701, encodeId=b423205e701b6, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Thu Mar 17 10:16:00 CST 2022, time=2022-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347562, encodeId=aaf0134e56230, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454882, encodeId=a3d3145488245, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471830, encodeId=0fed14e18308d, content=<a href='/topic/show?id=4aee984e7a' target=_blank style='color:#2F92EE;'>#inflammatory#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9847, encryptionId=4aee984e7a, topicName=inflammatory)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71167160770, createdName=pyaili, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512692, encodeId=d79715126921e, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541721, encodeId=413c1541e21ce, content=<a href='/topic/show?id=d6e6599e27' target=_blank style='color:#2F92EE;'>#Diseases#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5997, encryptionId=d6e6599e27, topicName=Diseases)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474713318057, createdName=Tamikia, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569785, encodeId=a5f71569e85ff, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=)]
    2022-03-17 lxg951
  5. [GetPortalCommentsPageByObjectIdResponse(id=2060825, encodeId=ef172060825a1, content=<a href='/topic/show?id=c73f3e96355' target=_blank style='color:#2F92EE;'>#发育障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37963, encryptionId=c73f3e96355, topicName=发育障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Tue Oct 19 06:16:00 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013653, encodeId=1f392013653bd, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, 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level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471830, encodeId=0fed14e18308d, content=<a href='/topic/show?id=4aee984e7a' target=_blank style='color:#2F92EE;'>#inflammatory#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9847, encryptionId=4aee984e7a, topicName=inflammatory)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71167160770, createdName=pyaili, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512692, encodeId=d79715126921e, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541721, encodeId=413c1541e21ce, content=<a href='/topic/show?id=d6e6599e27' target=_blank style='color:#2F92EE;'>#Diseases#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5997, encryptionId=d6e6599e27, topicName=Diseases)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474713318057, createdName=Tamikia, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569785, encodeId=a5f71569e85ff, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=)]
    2021-07-13 neurowu
  6. [GetPortalCommentsPageByObjectIdResponse(id=2060825, encodeId=ef172060825a1, content=<a href='/topic/show?id=c73f3e96355' target=_blank style='color:#2F92EE;'>#发育障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37963, encryptionId=c73f3e96355, topicName=发育障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Tue Oct 19 06:16:00 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013653, encodeId=1f392013653bd, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, 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encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Thu Mar 17 10:16:00 CST 2022, time=2022-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347562, encodeId=aaf0134e56230, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454882, encodeId=a3d3145488245, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, 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href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541721, encodeId=413c1541e21ce, content=<a href='/topic/show?id=d6e6599e27' target=_blank style='color:#2F92EE;'>#Diseases#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5997, encryptionId=d6e6599e27, topicName=Diseases)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474713318057, createdName=Tamikia, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569785, encodeId=a5f71569e85ff, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=)]
    2021-07-13 xiaoyeshuang
  7. [GetPortalCommentsPageByObjectIdResponse(id=2060825, encodeId=ef172060825a1, content=<a href='/topic/show?id=c73f3e96355' target=_blank style='color:#2F92EE;'>#发育障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37963, encryptionId=c73f3e96355, topicName=发育障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Tue Oct 19 06:16:00 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013653, encodeId=1f392013653bd, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, 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2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569785, encodeId=a5f71569e85ff, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Tue Jul 13 07:16:00 CST 2021, time=2021-07-13, status=1, ipAttribution=)]
  8. 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    2021-07-13 Tamikia
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    2021-07-13 dongjia2015

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