Pediatric Diabetes:青少年人群的糖尿病类型不同,抑郁症状也有所不同?

2019-11-24 国际糖尿病编辑部 国际糖尿病

既往曾有研究显示,糖尿病与抑郁密切相关。那么,在青少年人群中,糖尿病与抑郁的关系如何?糖尿病类型对两者的关系又有何影响?近期,美国斯坦福大学医学院的Jessie J. Wong等人专门就此问题进行了相应研究。

既往曾有研究显示,糖尿病与抑郁密切相关。那么,在青少年人群中,糖尿病与抑郁的关系如何?糖尿病类型对两者的关系又有何影响?近期,美国斯坦福大学医学院的Jessie J. Wong等人专门就此问题进行了相应研究。

研究概览

研究者分析了149例患有1型糖尿病(n=122)或2型糖尿病(n=27)的青少年和年轻成年人的数据,这些青少年和年轻成年人在常规门诊预约期间完成了基于网络的抑郁症筛查。受试者完成了9项患者健康问卷和7项PROMIS儿科全球健康量表。研究者对此进行了图表回顾,以评估诊断糖尿病持续时间和健康状况指标,并使用回归模型分析不同糖尿病类型抑郁症状的差异。

研究结果

主要研究结果显示在受试者中,7.4%存在临床显著抑郁症状。与1型糖尿病青少年相比,2型糖尿病青少年的抑郁症状评分更高(4.89 vs. 2.99,P =0.025)。进一步分析发现,性别与抑郁症状之间无相关性,糖尿病持续时间仅在2型糖尿病青少年中与抑郁症状相关(P=0.043)。不过,一般健康状况和糖尿病类型对抑郁症状的影响存在交互作用。具体来说,与1型糖尿病青少年相比,在2型糖尿病青少年中一般健康状况与抑郁症状负相关关系更强。

在校正糖尿病病程及性别后,一般健康状况较差的人群抑郁症状会更严重,尤以在2型糖尿病青少年中更显著。在一般健康状况较好的青少年中,与2型糖尿病患者相比,1型糖尿病患者会有更多抑郁症状(P=0.035)。

研究总结

从该研究结果来看,临床医生在管理青少年糖尿病患者时应尤其注意对一般健康状况较差的2型青少年进行抑郁症状的评估。此外,针对青少年糖尿病患者进行抑郁干预时有必要根据糖尿病类型及健康状况进行有针对性的选择。对于2型糖尿病青少年,有必要针对导致其病程延长的因素进行干预。

原始出处:
Jessie J. Wong  Ananta Addala  Hiba Abujaradeh, et al. Depression in context: Important considerations for youth with type 1 vs type 2 diabetes.  Pediatric Diabetes. 23 October 2019.

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    2019-12-07 hbwxf
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    2020-05-22 feather89
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    2019-11-24 misszhang

    谢谢MedSci提供最新的资讯

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